Ube2u ubiquitin-conjugating enzyme E2U (putative) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ube2uprovided by MGI
Official Full Name: ubiquitin-conjugating enzyme E2U (putative)provided by MGI
Primary source: MGI:MGI:3588216
See related: Ensembl:ENSMUSG00000069733 AllianceGenome:MGI:3588216
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to enable ubiquitin conjugating enzyme activity. Predicted to be involved in protein K11-linked ubiquitination and protein K48-linked ubiquitination. Predicted to be active in nucleus. Is expressed in brain; oviduct; spinal cord; and testis. Orthologous to human UBE2U (ubiquitin conjugating enzyme E2 U). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in testis adult (RPKM 11.6) and placenta adult (RPKM 1.0) See more
Orthologs: human all
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Genomic context

Location:: 4 C6; 4 45.72 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (100336064..100407342)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (100478867..100550145)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3)
Endonuclease-mediated (1) 1 citation

General gene information

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Markers

D1S2673 (e-PCR), detects polymorphism
- UniSTS:9642

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ubiquitin conjugating enzyme activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in anaphase-promoting complex-dependent catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein polyubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of mitotic metaphase/anaphase transition	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: ubiquitin-conjugating enzyme E2 U

NP_001028945.2

EC 6.3.2.19

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001033773.4 → NP_001028945.2 ubiquitin-conjugating enzyme E2 U

Status: VALIDATED

Source sequence(s)

AK133379, AL670290, AV266581, BB616918, BC172031

Consensus CDS

CCDS18390.2

UniProtKB/TrEMBL

B1AUC4, B7ZWG1

Related

ENSMUSP00000137472.2, ENSMUST00000133493.9

Conserved Domains (2) summary

COG5078
Location:1 → 146

COG5078; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]

cd00195
Location:8 → 146

UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...