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Zfp69 zinc finger protein 69 [ Mus musculus (house mouse) ]

Gene ID: 381549, updated on 8-Feb-2024

Summary

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Official Symbol
Zfp69provided by MGI
Official Full Name
zinc finger protein 69provided by MGI
Primary source
MGI:MGI:107794
See related
Ensembl:ENSMUSG00000064141 AllianceGenome:MGI:107794
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Krab2; Zfp63; Gm1029
Summary
Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in regulation of lipid metabolic process. Located in nucleus. Is expressed in several structures, including branchial arch; early conceptus; heart; and ovary. Orthologous to human ZFP69 (ZFP69 zinc finger protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 1.2), limb E14.5 (RPKM 0.9) and 28 other tissues See more
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Genomic context

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Location:
4 D2.2; 4 56.66 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (120786201..120808898, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (120930133..120951701, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_11258 Neighboring gene predicted gene, 24678 Neighboring gene STARR-positive B cell enhancer ABC_E10254 Neighboring gene STARR-positive B cell enhancer ABC_E6207 Neighboring gene exonuclease 5 Neighboring gene STARR-positive B cell enhancer ABC_E6208 Neighboring gene STARR-positive B cell enhancer ABC_E4659 Neighboring gene small ArfGAP 2 Neighboring gene microRNA 7015 Neighboring gene STARR-positive B cell enhancer ABC_E6209 Neighboring gene STARR-positive B cell enhancer ABC_E3508 Neighboring gene STARR-positive B cell enhancer ABC_E10255 Neighboring gene STARR-positive B cell enhancer ABC_E6210 Neighboring gene STARR-seq mESC enhancer starr_11259 Neighboring gene collagen, type IX, alpha 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Role of zinc finger transcription factor zfp69 in body fat storage and diabetes susceptibility of mice. Scherneck S, et al. Results Probl Cell Differ, 2010. PMID 20865372
  2. Genetic background (DDD/Sgn versus C57BL/6J) strongly influences postnatal growth of male mice carrying the A(y) allele at the agouti locus: identification of quantitative trait loci associated with diabetes and body weight loss. Suto J, et al. BMC Genet, 2013 May 4. PMID 23641944, Free PMC Article
  3. Positional cloning of zinc finger domain transcription factor Zfp69, a candidate gene for obesity-associated diabetes contributed by mouse locus Nidd/SJL. Scherneck S, et al. PLoS Genet, 2009 Jul. PMID 19578398, Free PMC Article
  4. The diabetes gene Zfp69 modulates hepatic insulin sensitivity in mice. Chung B, et al. Diabetologia, 2015 Oct. PMID 26232096, Free PMC Article
  5. Mouse ES cell-derived cardiac precursor cells are multipotent and facilitate identification of novel cardiac genes. Christoforou N, et al. J Clin Invest, 2008 Mar. PMID 18246200, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Zfp69 mediates hyperlipidaemia, liver fat accumulation and mild insulin resistance. However, it does not induce type 2 diabetes, suggesting that the diabetogenic effect of the Zfp69 locus requires synergy with other as yet unidentified genes.
    Title: The diabetes gene Zfp69 modulates hepatic insulin sensitivity in mice.
  2. Zfp69 mRNA-expression was significantly higher in diabetic subjects than in unaffected controls.
    Title: Role of zinc finger transcription factor zfp69 in body fat storage and diabetes susceptibility of mice.
  3. Zfp69 is the most likely candidate for the diabetogenic effect of Nidd/SJL locus.
    Title: Positional cloning of zinc finger domain transcription factor Zfp69, a candidate gene for obesity-associated diabetes contributed by mouse locus Nidd/SJL.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of lipid metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
zinc finger protein 69
Names
Zfp63p
zinc finger protein 642

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001005788.3 → NP_001005788.2  zinc finger protein 69 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL731722, BC066020, CK624262
    Consensus CDS
    CCDS18597.2
    UniProtKB/Swiss-Prot
    A2A761
    Related
    ENSMUSP00000101887.2, ENSMUST00000106280.8
    Conserved Domains (5) summary
    smart00349
    Location:131 → 192
    KRAB; krueppel associated box
    smart01104
    Location:52 → 128
    CTD; Spt5 C-terminal nonapeptide repeat binding Spt4
    COG5048
    Location:279 → 510
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:326 → 346
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:534 → 559
    zf-H2C2_2; Zinc-finger double domain

  2. NM_001384119.1 → NP_001371048.1  zinc finger protein 69 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL606904, AL731722
    Conserved Domains (5) summary
    smart00349
    Location:131 → 191
    KRAB; krueppel associated box
    smart01104
    Location:52 → 128
    CTD; Spt5 C-terminal nonapeptide repeat binding Spt4
    COG5048
    Location:278 → 509
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:325 → 345
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:533 → 558
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    120786201..120808898 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036164209.1 → XP_036020102.1  zinc finger protein 69 isoform X1

    Conserved Domains (5) summary
    smart00349
    Location:131 → 171
    KRAB; krueppel associated box
    smart01104
    Location:52 → 128
    CTD; Spt5 C-terminal nonapeptide repeat binding Spt4
    COG5048
    Location:246 → 477
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:293 → 313
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:501 → 526
    zf-H2C2_2; Zinc-finger double domain

  2. XM_036164211.1 → XP_036020104.1  zinc finger protein 69 isoform X3

    UniProtKB/TrEMBL
    Q6NZQ1
    Conserved Domains (4) summary
    COG5048
    Location:120 → 351
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:167 → 187
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:375 → 400
    zf-H2C2_2; Zinc-finger double domain
    cl02581
    Location:1 → 33
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box

  3. XM_036164212.1 → XP_036020105.1  zinc finger protein 69 isoform X3

    UniProtKB/TrEMBL
    Q6NZQ1
    Conserved Domains (4) summary
    COG5048
    Location:120 → 351
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:167 → 187
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:375 → 400
    zf-H2C2_2; Zinc-finger double domain
    cl02581
    Location:1 → 33
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box

  4. XM_036164210.1 → XP_036020103.1  zinc finger protein 69 isoform X2

    Conserved Domains (4) summary
    smart00349
    Location:12 → 73
    KRAB; krueppel associated box
    COG5048
    Location:160 → 391
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:207 → 227
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:415 → 440
    zf-H2C2_2; Zinc-finger double domain

  5. XM_017320292.2 → XP_017175781.1  zinc finger protein 69 isoform X3

    UniProtKB/TrEMBL
    Q6NZQ1
    Conserved Domains (4) summary
    COG5048
    Location:120 → 351
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:167 → 187
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:375 → 400
    zf-H2C2_2; Zinc-finger double domain
    cl02581
    Location:1 → 33
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box

  6. XM_006503211.4 → XP_006503274.1  zinc finger protein 69 isoform X4

    See identical proteins and their annotated locations for XP_006503274.1

    Conserved Domains (3) summary
    COG5048
    Location:88 → 319
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:135 → 155
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:343 → 368
    zf-H2C2_2; Zinc-finger double domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A2A761.1 GenPept UniProtKB/Swiss-Prot:A2A761

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