Kpna7 karyopherin subunit alpha 7 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Kpna7provided by MGI
Official Full Name: karyopherin subunit alpha 7provided by MGI
Primary source: MGI:MGI:2141165
See related: Ensembl:ENSMUSG00000038770 AllianceGenome:MGI:2141165
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gm1055
Summary: Predicted to enable nuclear import signal receptor activity and nuclear localization sequence binding activity. Acts upstream of or within blastocyst development; negative regulation of gene expression; and positive regulation of macromolecule metabolic process. Located in nucleus and spindle. Is expressed in early conceptus; liver; and oocyte. Orthologous to human KPNA7 (karyopherin subunit alpha 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in ovary adult (RPKM 5.4) and testis adult (RPKM 2.0) See more
Orthologs: human all
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Genomic context

Location:: 5 G2; 5 84.91 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (144920537..144946446, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (144983727..145009636, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

a decreased H7N9 influenza A virus polymerase activity when importin-alpha7 was silenced by siRNA, is reported.
Title: H7N9 Influenza A Virus Exhibits Importin-α7-Mediated Replication in the Mammalian Respiratory Tract.
a novel importin alpha family member with distinct subcellular localization and nuclear localization signal binding characteristics
Title: Karyopherin alpha7 (KPNA7), a divergent member of the importin alpha family of nuclear import receptors.
knocking out of Kpna7 induced abnormalities of gene expression (dppa2, dppa4, and piwil2) and epigenetic modifications (down-regulation of histone H3K27me3). Biochemical analysis showed that KPNA7 interacts with KPNB1 (importin-beta1).
Title: Novel importin-alpha family member Kpna7 is required for normal fertility and fecundity in the mouse.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Endonuclease-mediated (3) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables nuclear import signal receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables nuclear localization sequence binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in NLS-bearing protein import into nucleus	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within blastocyst development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within epigenetic regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein import into nucleus	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of NLS-dependent protein nuclear import complex	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	NAS Non-traceable Author Statement more info	PubMed
located_in female germ cell nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	NAS Non-traceable Author Statement more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in spindle	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: importin subunit alpha-8

Names: importin alpha 2; karyopherin alpha 7 (importin alpha 8); nuclear transport receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001013774.2 → NP_001013796.2 importin subunit alpha-8 isoform 2

See identical proteins and their annotated locations for NP_001013796.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.

Source sequence(s)

AC113295

Consensus CDS

CCDS19852.1

UniProtKB/Swiss-Prot

C0LLJ0, C0LLJ1, Q3UWY3, Q58HC5

Related

ENSMUSP00000106300.2, ENSMUST00000110672.8

Conserved Domains (5) summary

COG5064
Location:2 → 492

SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]

cd00020
Location:106 → 226

ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...

pfam01749
Location:7 → 89

IBB; Importin beta binding domain

pfam16186
Location:450 → 491

Arm_3; Atypical Arm repeat

sd00043
Location:107 → 139

ARM; armadillo repeat [structural motif]
NM_001347531.1 → NP_001334460.1 importin subunit alpha-8 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1).

Source sequence(s)

AC113295

Consensus CDS

CCDS84996.1

UniProtKB/Swiss-Prot

C0LLJ0

Related

ENSMUSP00000106301.2, ENSMUST00000110673.8