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Zbtb2 zinc finger and BTB domain containing 2 [ Mus musculus (house mouse) ]

Gene ID: 381990, updated on 5-Mar-2024

Summary

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Official Symbol
Zbtb2provided by MGI
Official Full Name
zinc finger and BTB domain containing 2provided by MGI
Primary source
MGI:MGI:2685949
See related
Ensembl:ENSMUSG00000075327 AllianceGenome:MGI:2685949
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm1103
Summary
Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and identical protein binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be active in nucleoplasm. Orthologous to human ZBTB2 (zinc finger and BTB domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 12.1), ovary adult (RPKM 5.6) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Zbtb2 in Genome Data Viewer
Location:
10 A1; 10 2.06 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (4317074..4353114, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (4367074..4388108, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 30570 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:6084769-6084970 Neighboring gene STARR-seq mESC enhancer starr_25646 Neighboring gene STARR-seq mESC enhancer starr_25645 Neighboring gene STARR-seq mESC enhancer starr_25640 Neighboring gene A kinase anchor protein 12 Neighboring gene predicted gene, 40592 Neighboring gene STARR-seq mESC enhancer starr_25637 Neighboring gene STARR-positive B cell enhancer ABC_E11428 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:5999414-5999597 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:5988889-5989072 Neighboring gene STARR-seq mESC enhancer starr_25630 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:5958087-5958270 Neighboring gene STARR-positive B cell enhancer ABC_E2315 Neighboring gene required for meiotic nuclear division 1 homolog Neighboring gene acidic residue methyltransferase 1 Neighboring gene STARR-seq mESC enhancer starr_25628 Neighboring gene coiled-coil domain containing 170 Neighboring gene predicted gene, 22739

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. ZBTB2 reads unmethylated CpG island promoters and regulates embryonic stem cell differentiation. Karemaker ID, et al. EMBO Rep, 2018 Apr. PMID 29437775, Free PMC Article
  2. ZBTB2, a novel master regulator of the p53 pathway. Jeon BN, et al. J Biol Chem, 2009 Jul 3. PMID 19380588, Free PMC Article
  3. ZBTB20 is crucial for the specification of a subset of callosal projection neurons and astrocytes in the mammalian neocortex. Medeiros de Araújo JA, et al. Development, 2021 Aug 15. PMID 34351428, Free PMC Article
  4. An expanded Oct4 interaction network: implications for stem cell biology, development, and disease. Pardo M, et al. Cell Stem Cell, 2010 Apr 2. PMID 20362542, Free PMC Article
  5. A direct physical interaction between Nanog and Sox2 regulates embryonic stem cell self-renewal. Gagliardi A, et al. EMBO J, 2013 Aug 14. PMID 23892456, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cytokine production IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of immune system process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger and BTB domain-containing protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033466.3 → NP_001028638.2  zinc finger and BTB domain-containing protein 2

    See identical proteins and their annotated locations for NP_001028638.2

    Status: VALIDATED

    Source sequence(s)
    AK132308, AK173184, BY444820
    Consensus CDS
    CCDS56674.1
    UniProtKB/TrEMBL
    Q3V1Q5, Q3V3W4
    Related
    ENSMUSP00000097656.3, ENSMUST00000100078.10
    Conserved Domains (4) summary
    sd00017
    Location:365 → 385
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:363 → 385
    zf-C2H2; Zinc finger, C2H2 type
    pfam00651
    Location:14 → 84
    BTB; BTB/POZ domain
    pfam13465
    Location:377 → 399
    zf-H2C2_2; Zinc-finger double domain

  2. NM_001359811.1 → NP_001346740.1  zinc finger and BTB domain-containing protein 2

    Status: VALIDATED

    Source sequence(s)
    AC133902, AK030936, AK160748, BC094553, BY443983
    Consensus CDS
    CCDS56674.1
    UniProtKB/TrEMBL
    Q3V1Q5, Q3V3W4
    Related
    ENSMUSP00000097655.4, ENSMUST00000100077.5
    Conserved Domains (4) summary
    sd00017
    Location:365 → 385
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:363 → 385
    zf-C2H2; Zinc finger, C2H2 type
    pfam00651
    Location:14 → 84
    BTB; BTB/POZ domain
    pfam13465
    Location:377 → 399
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    4317074..4353114 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036155875.1 → XP_036011768.1  zinc finger and BTB domain-containing protein 2 isoform X1

    UniProtKB/TrEMBL
    Q505G7
    Conserved Domains (4) summary
    sd00017
    Location:286 → 306
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl38908
    Location:1 → 38
    BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
    pfam00096
    Location:284 → 306
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:298 → 320
    zf-H2C2_2; Zinc-finger double domain
Nucleotide Protein Strain
Heading Accession and Version

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