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Adgrg5 adhesion G protein-coupled receptor G5 [ Mus musculus (house mouse) ]

Gene ID: 382045, updated on 11-Apr-2024

Summary

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Official Symbol
Adgrg5provided by MGI
Official Full Name
adhesion G protein-coupled receptor G5provided by MGI
Primary source
MGI:MGI:2685955
See related
Ensembl:ENSMUSG00000061577 AllianceGenome:MGI:2685955
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PGR27; Gm1109; Gpr114
Summary
Predicted to enable G protein-coupled receptor activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway. Predicted to act upstream of or within signal transduction. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be integral component of plasma membrane. Is expressed in stomach and testis. Orthologous to human ADGRG5 (adhesion G protein-coupled receptor G5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in spleen adult (RPKM 15.2), thymus adult (RPKM 10.3) and 8 other tissues See more
Orthologs
human all
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Genomic context

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Location:
8 C5; 8 47.03 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (95648439..95669921)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (94921811..94943293)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene polymerase (RNA) II (DNA directed) polypeptide C Neighboring gene docking protein 4 Neighboring gene coiled-coil domain containing 102A Neighboring gene STARR-positive B cell enhancer mm9_chr8:97441323-97441623 Neighboring gene STARR-positive B cell enhancer ABC_E8258 Neighboring gene STARR-positive B cell enhancer ABC_E3795 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:97500803-97501004 Neighboring gene predicted gene, 30968 Neighboring gene adhesion G protein-coupled receptor G1 Neighboring gene predicted gene, 51544 Neighboring gene adhesion G protein-coupled receptor G3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The constitutive activity of the adhesion GPCR GPR114/ADGRG5 is mediated by its tethered agonist. Wilde C, et al. FASEB J, 2016 Feb. PMID 26499266
  2. The human and mouse repertoire of the adhesion family of G-protein-coupled receptors. Bjarnadóttir TK, et al. Genomics, 2004 Jul. PMID 15203201
  3. International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors. Hamann J, et al. Pharmacol Rev, 2015. PMID 25713288, Free PMC Article
  4. The G protein-coupled receptor repertoires of human and mouse. Vassilatis DK, et al. Proc Natl Acad Sci U S A, 2003 Apr 15. PMID 12679517, Free PMC Article
  5. A mouse knockout library for secreted and transmembrane proteins. Tang T, et al. Nat Biotechnol, 2010 Jul. PMID 20562862

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transmembrane signaling receptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
adhesion G-protein coupled receptor G5
Names
G protein coupled receptor Gpr114
G protein-coupled receptor 114
G-protein coupled receptor PGR27
probable G-protein coupled receptor 114

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033468.3 → NP_001028640.2  adhesion G-protein coupled receptor G5 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001028640.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has two alternate splice sites in the 5' UTR and CDS respectively, as compared to variant 1. The resulting isoform (2) lacks an internal amino acid, as compared to isoform 1.
    Source sequence(s)
    AK028878, BC144851, BY547428
    Consensus CDS
    CCDS22552.1
    UniProtKB/Swiss-Prot
    Q3V3Z3
    Related
    ENSMUSP00000074155.4, ENSMUST00000074570.10
    Conserved Domains (3) summary
    cd14964
    Location:243 → 267
    7tm_GPCRs; TM helix 1 [structural motif]
    pfam01825
    Location:184 → 228
    GPS; GPCR proteolysis site, GPS, motif
    cl28897
    Location:241 → 513
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  2. NM_001145972.1 → NP_001139444.1  adhesion G-protein coupled receptor G5 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001139444.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AK028878, BC144851, BY547428
    Consensus CDS
    CCDS52637.1
    UniProtKB/Swiss-Prot
    A6H6A1, G5E8G8, Q3V3Z3
    Related
    ENSMUSP00000132628.2, ENSMUST00000166802.9
    Conserved Domains (3) summary
    cd14964
    Location:244 → 268
    7tm_GPCRs; TM helix 1 [structural motif]
    pfam01825
    Location:184 → 228
    GPS; GPCR proteolysis site, GPS, motif
    cl28897
    Location:242 → 514
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    95648439..95669921
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017312886.1 → XP_017168375.1  adhesion G-protein coupled receptor G5 isoform X2

    UniProtKB/Swiss-Prot
    A6H6A1, G5E8G8, Q3V3Z3
    Conserved Domains (3) summary
    cd14964
    Location:244 → 268
    7tm_GPCRs; TM helix 1 [structural motif]
    pfam01825
    Location:184 → 228
    GPS; GPCR proteolysis site, GPS, motif
    cl28897
    Location:242 → 514
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  2. XM_017312885.1 → XP_017168374.1  adhesion G-protein coupled receptor G5 isoform X2

    UniProtKB/Swiss-Prot
    A6H6A1, G5E8G8, Q3V3Z3
    Conserved Domains (3) summary
    cd14964
    Location:244 → 268
    7tm_GPCRs; TM helix 1 [structural motif]
    pfam01825
    Location:184 → 228
    GPS; GPCR proteolysis site, GPS, motif
    cl28897
    Location:242 → 514
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  3. XM_011248425.1 → XP_011246727.1  adhesion G-protein coupled receptor G5 isoform X3

    See identical proteins and their annotated locations for XP_011246727.1

    Conserved Domains (3) summary
    cd14964
    Location:189 → 214
    7tm_GPCRs; TM helix 1 [structural motif]
    pfam01825
    Location:130 → 174
    GPS; GPCR proteolysis site, GPS, motif
    cl28897
    Location:188 → 460
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  4. XM_017312884.1 → XP_017168373.1  adhesion G-protein coupled receptor G5 isoform X2

    UniProtKB/Swiss-Prot
    A6H6A1, G5E8G8, Q3V3Z3
    Conserved Domains (3) summary
    cd14964
    Location:244 → 268
    7tm_GPCRs; TM helix 1 [structural motif]
    pfam01825
    Location:184 → 228
    GPS; GPCR proteolysis site, GPS, motif
    cl28897
    Location:242 → 514
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  5. XM_011248422.1 → XP_011246724.1  adhesion G-protein coupled receptor G5 isoform X1

    See identical proteins and their annotated locations for XP_011246724.1

    UniProtKB/Swiss-Prot
    Q3V3Z3
    Conserved Domains (3) summary
    cd14964
    Location:243 → 267
    7tm_GPCRs; TM helix 1 [structural motif]
    pfam01825
    Location:184 → 228
    GPS; GPCR proteolysis site, GPS, motif
    cl28897
    Location:241 → 513
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3V3Z3.3 GenPept UniProtKB/Swiss-Prot:Q3V3Z3

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