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Ces3a carboxylesterase 3A [ Mus musculus (house mouse) ]

Gene ID: 382053, updated on 8-Feb-2024

Summary

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Official Symbol
Ces3aprovided by MGI
Official Full Name
carboxylesterase 3Aprovided by MGI
Primary source
MGI:MGI:102773
See related
Ensembl:ENSMUSG00000069922 AllianceGenome:MGI:102773
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ces3; Es31; Ces31
Summary
Predicted to enable methyl indole-3-acetate esterase activity. Predicted to be located in endoplasmic reticulum. Orthologous to human CES3 (carboxylesterase 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward liver adult (RPKM 311.9) See more
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Genomic context

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See Ces3a in Genome Data Viewer
Location:
8 D3; 8 53.04 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (105775208..105788560)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (105048576..105061928)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene carboxylesterase 2E pseudogene Neighboring gene carboxylesterase 2H Neighboring gene STARR-seq mESC enhancer starr_22519 Neighboring gene carboxylesterase 3B Neighboring gene microtubule-associated protein, RP/EB family, member 1 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Novel regulatory roles of carboxylesterase 3 in lipid metabolism and browning in 3T3-L1 white adipocytes. Mukherjee S, et al. Appl Physiol Nutr Metab, 2019 Oct. PMID 30807212
  2. Integrated phenotypic and activity-based profiling links Ces3 to obesity and diabetes. Dominguez E, et al. Nat Chem Biol, 2014 Feb. PMID 24362705, Free PMC Article
  3. Liver-specific cholesteryl ester hydrolase deficiency attenuates sterol elimination in the feces and increases atherosclerosis in ldlr-/- mice. Bie J, et al. Arterioscler Thromb Vasc Biol, 2013 Aug. PMID 23744992, Free PMC Article
  4. Cloning and nucleotide sequence of a novel, male-predominant carboxylesterase in mouse liver. Aida K, et al. Biochim Biophys Acta, 1993 Jul 18. PMID 7916639
  5. Mammalian carboxylesterase 3: comparative genomics and proteomics. Holmes RS, et al. Genetica, 2010 Jul. PMID 20422440, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. activation of Ces3 contributes in the browning of white adipocytes, and maintains a balance in lipid metabolism, which could be a potential strategy in fighting against obesity
    Title: Novel regulatory roles of carboxylesterase 3 in lipid metabolism and browning in 3T3-L1 white adipocytes.
  2. Study highlights a lipolytic signaling induced by Ces3 as a unique process to regulate thermogenesis in adipose tissue.
    Title: A Unique Role of Carboxylesterase 3 (Ces3) in β-Adrenergic Signaling-Stimulated Thermogenesis.
  3. This carboxylesterase proetin is linked to obesity and diabetes in mice
    Title: Integrated phenotypic and activity-based profiling links Ces3 to obesity and diabetes.
  4. Hepatic Ces3 modulates the hydrolysis of lipoprotein-delivered cholesterol esters and thereby regulates free cholesterol and bile acid secretion into the feces.
    Title: Liver-specific cholesteryl ester hydrolase deficiency attenuates sterol elimination in the feces and increases atherosclerosis in ldlr-/- mice.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • MGC65472, MGC67828

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables carboxylesterase activity IEA
Inferred from Electronic Annotation
more info
  
enables carboxylic ester hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
carboxylesterase 3A
Names
Es-male carboxylesterase
esterase 31
liver carboxylesterase 31
NP_001158153.1
NP_941074.1
XP_011246729.1
XP_030099511.1
XP_030099512.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164681.1 → NP_001158153.1  carboxylesterase 3A isoform 2 precursor

    See identical proteins and their annotated locations for NP_001158153.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the central coding region, compared to variant 1. The resulting isoform (2) lacks an internal segment, compared to isoform 1.
    Source sequence(s)
    AC164311, BC061004, CB952677
    Consensus CDS
    CCDS52652.1
    UniProtKB/Swiss-Prot
    Q63880
    Related
    ENSMUSP00000090911.4, ENSMUST00000093223.5
    Conserved Domains (2) summary
    COG0657
    Location:75 → 245
    Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
    pfam00135
    Location:36 → 500
    COesterase; Carboxylesterase family

  2. NM_198672.1 → NP_941074.1  carboxylesterase 3A isoform 1 precursor

    See identical proteins and their annotated locations for NP_941074.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC164311, AK138932, CB952677
    Consensus CDS
    CCDS52651.1
    UniProtKB/Swiss-Prot
    Q3UEJ0, Q3UU08, Q63880, Q6P8Z0, Q6PG74, Q810S9
    Related
    ENSMUSP00000090910.6, ENSMUST00000093222.13
    Conserved Domains (2) summary
    COG0657
    Location:75 → 245
    Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
    pfam00135
    Location:36 → 547
    COesterase; Carboxylesterase family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    105775208..105788560
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011248427.3 → XP_011246729.1  carboxylesterase 3A isoform X1

    Conserved Domains (1) summary
    pfam00135
    Location:37 → 507
    COesterase; Carboxylesterase family

  2. XM_030243651.1 → XP_030099511.1  carboxylesterase 3A isoform X2

    Conserved Domains (1) summary
    cl21494
    Location:1 → 302
    Abhydrolase; alpha/beta hydrolases

  3. XM_030243652.1 → XP_030099512.1  carboxylesterase 3A isoform X3

    Conserved Domains (1) summary
    cl21494
    Location:1 → 255
    Abhydrolase; alpha/beta hydrolases
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q63880.2 GenPept UniProtKB/Swiss-Prot:Q63880

Gene LinkOut

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