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CG1317 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 38300, updated on 10-May-2024

Summary

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Official Symbol
CG1317provided by FlyBase
Primary source
FLYBASE:FBgn0035333
Locus tag
Dmel_CG1317
See related
AllianceGenome:FB:FBgn0035333
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG1317; Teb4
Summary
Predicted to enable ubiquitin protein ligase activity and zinc ion binding activity. Predicted to be involved in protein ubiquitination and ubiquitin-dependent ERAD pathway. Predicted to be integral component of endoplasmic reticulum membrane. Is expressed in adult head. Human ortholog(s) of this gene implicated in familial adult myoclonic epilepsy 3. Orthologous to human MARCHF6 (membrane associated ring-CH-type finger 6). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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See CG1317 in Genome Data Viewer
Location:
62D7-62D7; 3-2 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (2367843..2371939, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (2367843..2371939, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Myosuppressin receptor 1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene mitochondrial ribosomal protein L23 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Amelioration of hepatic steatosis by dietary essential amino acid-induced ubiquitination. Zhang Y, et al. Mol Cell, 2022 Apr 21. PMID 35245436
  2. Wolbachia endosymbionts subvert the endoplasmic reticulum to acquire host membranes without triggering ER stress. Fattouh N, et al. PLoS Negl Trop Dis, 2019 Mar. PMID 30893296, Free PMC Article
  3. NatB regulates Rb mutant cell death and tumor growth by modulating EGFR/MAPK signaling through the N-end rule pathways. Sheng Z, et al. PLoS Genet, 2020 Jun. PMID 32559195, Free PMC Article
  4. Comprehensively surveying structure and function of RING domains from Drosophila melanogaster. Ying M, et al. PLoS One, 2011. PMID 21912646, Free PMC Article
  5. Protein phosphorylation changes reveal new candidates in the regulation of egg activation and early embryogenesis in D. melanogaster. Krauchunas AR, et al. Dev Biol, 2012 Oct 1. PMID 22884528, Free PMC Article

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ubiquitin protein ligase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables ubiquitin-protein transferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding ISM
Inferred from Sequence Model
more info
 PubMed 
Process Evidence Code Pubs
involved_in ERAD pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein ubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG1317-PB
CG1317-PC
CG1317-PD

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    2367843..2371939 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001299984.1 → NP_001286913.1  uncharacterized protein Dmel_CG1317, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286913.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q6AWJ1, Q9W023
    Conserved Domains (2) summary
    smart00744
    Location:9 → 56
    RINGv; The RING-variant domain is a C4HC3 zinc-finger like motif found in a number of cellular and viral proteins
    TIGR04346
    Location:737 → 913
    DotA_TraY; conjugal transfer/type IV secretion protein DotA/TraY

  2. NM_001169857.2 → NP_001163328.1  uncharacterized protein Dmel_CG1317, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163328.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q6AWJ1, Q9W023
    Conserved Domains (2) summary
    smart00744
    Location:9 → 56
    RINGv; The RING-variant domain is a C4HC3 zinc-finger like motif found in a number of cellular and viral proteins
    TIGR04346
    Location:737 → 913
    DotA_TraY; conjugal transfer/type IV secretion protein DotA/TraY

  3. NM_139458.4 → NP_647715.2  uncharacterized protein Dmel_CG1317, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_647715.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q6AWJ1, Q9W023
    Related
    FBpp0072779
    Conserved Domains (2) summary
    smart00744
    Location:9 → 56
    RINGv; The RING-variant domain is a C4HC3 zinc-finger like motif found in a number of cellular and viral proteins
    TIGR04346
    Location:737 → 913
    DotA_TraY; conjugal transfer/type IV secretion protein DotA/TraY
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6AWJ1 Q6AWJ1
Q95TW3 Q95TW3
Q9W023 Q9W023

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