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PIG-C Phosphatidylinositol glycan anchor biosynthesis class C [ Drosophila melanogaster (fruit fly) ]

Gene ID: 38410, updated on 10-May-2024

Summary

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Official Symbol
PIG-Cprovided by FlyBase
Official Full Name
Phosphatidylinositol glycan anchor biosynthesis class Cprovided by FlyBase
Primary source
FLYBASE:FBgn0035435
Locus tag
Dmel_CG12077
See related
AllianceGenome:FB:FBgn0035435
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG12077; Dmel\CG12077; PIGC
Summary
Predicted to enable phosphatidylinositol N-acetylglucosaminyltransferase activity. Involved in GPI anchor biosynthetic process and rhabdomere membrane biogenesis. Predicted to be integral component of membrane. Predicted to be part of glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex. Is expressed in organism. Human ortholog(s) of this gene implicated in autosomal recessive non-syndromic intellectual disability. Orthologous to human PIGC (phosphatidylinositol glycan anchor biosynthesis class C). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See PIG-C in Genome Data Viewer
Location:
63D1-63D1; 3-8 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (3318028..3319232, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (3318028..3319232, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Drosomycin-like 4 Neighboring gene Drosomycin-like 5 Neighboring gene uncharacterized protein Neighboring gene Dolichyl-phosphate mannosyltransferase subunit 2 Neighboring gene Striatin interacting protein Neighboring gene Glutathione peroxidase homolog with thioredoxin peroxidase activity

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Drosophila Strip serves as a platform for early endosome organization during axon elongation. Sakuma C, et al. Nat Commun, 2014 Oct 14. PMID 25312435, Free PMC Article
  2. Variant-to-gene mapping followed by cross-species genetic screening identifies GPI-anchor biosynthesis as a regulator of sleep. Palermo J, et al. Sci Adv, 2023 Jan 6. PMID 36608130, Free PMC Article
  3. GPI biosynthesis is essential for rhodopsin sorting at the trans-Golgi network in Drosophila photoreceptors. Satoh T, et al. Development, 2013 Jan 15. PMID 23250212
  4. Steroid Signaling Establishes a Female Metabolic State and Regulates SREBP to Control Oocyte Lipid Accumulation. Sieber MH, et al. Curr Biol, 2015 Apr 20. PMID 25802149, Free PMC Article
  5. A genome-wide CRISPR screen identifies DPM1 as a modifier of DPAGT1 deficiency and ER stress. Dalton HM, et al. PLoS Genet, 2022 Sep. PMID 36166480, Free PMC Article

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in GPI anchor biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in GPI anchor biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in rhabdomere membrane biogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
phosphatidylinositol glycan anchor biosynthesis class C
Names
CG12077-PB
CG12077-PC
PIG-C-PB
PIG-C-PC
phosphatidylinositol glycan anchor biosynthesis, class C
phosphatidylinositol glycan anchor biosynthesis, class C ortholog

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    3318028..3319232 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001363927.1 → NP_001350858.1  phosphatidylinositol glycan anchor biosynthesis class C, isoform C [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A2U8U156, B3DND5
    Conserved Domains (1) summary
    pfam06432
    Location:12 → 270
    GPI2; Phosphatidylinositol N-acetylglucosaminyltransferase

  2. NM_139547.2 → NP_647804.2  phosphatidylinositol glycan anchor biosynthesis class C, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_647804.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    B3DND5, Q9VZR1
    Conserved Domains (1) summary
    pfam06432
    Location:12 → 270
    GPI2; Phosphatidylinositol N-acetylglucosaminyltransferase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A2U8U156 A0A2U8U156
Q9VZR1 Q9VZR1

Gene LinkOut

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