U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

CG12766 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 38462, updated on 11-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
CG12766provided by FlyBase
Primary source
FLYBASE:FBgn0035476
Locus tag
Dmel_CG12766
See related
AllianceGenome:FB:FBgn0035476
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG12766
Summary
Predicted to enable alditol:NADP+ 1-oxidoreductase activity. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in several diseases, including 46,XY sex reversal 8; diabetic neuropathy; diabetic retinopathy; leukemia (multiple); and type 2 diabetes mellitus. Orthologous to several human genes including AKR1B1 (aldo-keto reductase family 1 member B); AKR1B10 (aldo-keto reductase family 1 member B10); and AKR1B15 (aldo-keto reductase family 1 member B15). [provided by Alliance of Genome Resources, Apr 2022]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See CG12766 in Genome Data Viewer
Location:
64A1-64A1; 3-10 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (3938624..3940125, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (3938624..3940125, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Ecdysone-induced protein 63F 1 Neighboring gene antisense RNA:Ecdysone-induced gene 63F 2 Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR43916 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Endurance exercise and selective breeding for longevity extend Drosophila healthspan by overlapping mechanisms. Sujkowski A, et al. Aging (Albany NY), 2015 Aug. PMID 26298685, Free PMC Article
  2. Defensive repertoire of Drosophila larvae in response to toxic fungi. Trienens M, et al. Mol Ecol, 2017 Oct. PMID 28746736
  3. Innate immune responses to paraquat exposure in a Drosophila model of Parkinson's disease. Maitra U, et al. Sci Rep, 2019 Sep 3. PMID 31481676, Free PMC Article
  4. First transcriptome profiling of D. melanogaster after development in a deep underground low radiation background laboratory. Zarubin M, et al. PLoS One, 2021. PMID 34351964, Free PMC Article
  5. Sir2 Acts through Hepatocyte Nuclear Factor 4 to maintain insulin Signaling and Metabolic Homeostasis in Drosophila. Palu RA, et al. PLoS Genet, 2016 Apr. PMID 27058248, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables aldose reductase (NADPH) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables aldose reductase (NADPH) activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
uncharacterized protein
Names
CG12766-PA
NP_647839.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    3938624..3940125 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_139582.3 → NP_647839.1  uncharacterized protein Dmel_CG12766 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_647839.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VZK8
    Related
    FBpp0073029
    Conserved Domains (2) summary
    COG0656
    Location:5 → 298
    ARA1; Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism]
    COG0667
    Location:12 → 299
    Tas; Predicted oxidoreductase (related to aryl-alcohol dehydrogenase) [General function prediction only]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VZK8 Q9VZK8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools
Miscellaneous