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Rcd5 Reduction in Cnn dots 5 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 38478, updated on 27-Mar-2024

Summary

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Official Symbol
Rcd5provided by FlyBase
Official Full Name
Reduction in Cnn dots 5provided by FlyBase
Primary source
FLYBASE:FBgn0263832
Locus tag
Dmel_CG1135
See related
AllianceGenome:FB:FBgn0263832
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG1135; dMCRS1; dMCRS2; Dmel\CG1135; l(3)r0166; l(3)rG166; MCRS1; MCRS2; p78
Summary
Predicted to enable G-quadruplex RNA binding activity. Involved in centriole replication and positive regulation of transcription by RNA polymerase II. Located in nucleus and polytene chromosome interband. Part of NSL complex. Is expressed in organism. Orthologous to human MCRS1 (microspherule protein 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See Rcd5 in Genome Data Viewer
Location:
64A4-64A4; 3-10 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (4040529..4042597)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (4040529..4042597)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR45042 Neighboring gene Gustatory receptor 64d Neighboring gene Gustatory receptor 64e Neighboring gene Gustatory receptor 64f Neighboring gene uncharacterized protein Neighboring gene Dpy-30-like 2 Neighboring gene uncharacterized protein Neighboring gene UDP-glycosyltransferase family 305 member A1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The NSL complex regulates housekeeping genes in Drosophila. Lam KC, et al. PLoS Genet, 2012. PMID 22723752, Free PMC Article
  2. RNAi-mediated depletion of the NSL complex subunits leads to abnormal chromosome segregation and defective centrosome duplication in Drosophila mitosis. Pavlova GA, et al. PLoS Genet, 2019 Sep. PMID 31527906, Free PMC Article
  3. An epigenetic regulator emerges as microtubule minus-end binding and stabilizing factor in mitosis. Meunier S, et al. Nat Commun, 2015 Aug 5. PMID 26243146, Free PMC Article
  4. Nutritional control of gene expression in Drosophila larvae via TOR, Myc and a novel cis-regulatory element. Li L, et al. BMC Cell Biol, 2010 Jan 20. PMID 20089194, Free PMC Article
  5. The NSL complex-mediated nucleosome landscape is required to maintain transcription fidelity and suppression of transcription noise. Lam KC, et al. Genes Dev, 2019 Apr 1. PMID 30819819, Free PMC Article

See all (56) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Results suggest that dMCRS2 is required for loading of RNAP II complexes on the cyclin gene promoters.
    Title: Drosophila MCRS2 associates with RNA polymerase II complexes to regulate transcription.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables G-quadruplex RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in centriole replication IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of Ino80 complex IEA
Inferred from Electronic Annotation
more info
  
part_of MLL1 complex IEA
Inferred from Electronic Annotation
more info
  
part_of NSL complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of NSL complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in polytene chromosome interband IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
reduction in Cnn dots 5
Names
CG1135-PA
Rcd5-PA
lethal (3) rG166

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    4040529..4042597
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_139595.3 → NP_647852.1  reduction in Cnn dots 5 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_647852.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VZJ3
    Related
    FBpp0073058
    Conserved Domains (2) summary
    cd00060
    Location:465 → 559
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    pfam13325
    Location:246 → 444
    MCRS_N; N-terminal region of micro-spherule protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VZJ3 Q9VZJ3

Gene LinkOut

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