sgl sugarless [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: sglprovided by FlyBase
Official Full Name: sugarlessprovided by FlyBase
Primary source: FLYBASE:FBgn0261445
Locus tag: Dmel_CG10072
See related: AllianceGenome:FB:FBgn0261445
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 8310; BG01214; CG10072; Dmel\CG10072; kiwi; l(3)05007; l(3)08310; l(3)10503; l(3)65CEd; l(3)SG9; Sgl; ska; sl; UDP-GlcDH; UDPGDH; XIII
Summary: Enables UDP-glucose 6-dehydrogenase activity. Involved in ameboidal-type cell migration; proteoglycan biosynthetic process; and segment polarity determination. Acts upstream of with a positive effect on fibroblast growth factor receptor signaling pathway. Predicted to be active in cytosol and nucleus. Is expressed in several structures, including embryonic head sensory system; embryonic/larval hemocyte; epithelium; extended germ band embryo; and gut section. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 84. Orthologous to human UGDH (UDP-glucose 6-dehydrogenase). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (6959554..6964758, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (6952654..6957858, complement)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables NAD binding	IEA Inferred from Electronic Annotation more info
enables UDP-glucose 6-dehydrogenase activity	IEA Inferred from Electronic Annotation more info
enables UDP-glucose 6-dehydrogenase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in chondroitin sulfate biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in epithelial cell migration, open tracheal system	IGI Inferred from Genetic Interaction more info	PubMed
involved_in epithelial cell migration, open tracheal system	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_positive_effect fibroblast growth factor receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_positive_effect fibroblast growth factor receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glycosaminoglycan biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glycosaminoglycan biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mesoderm migration involved in gastrulation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in segment polarity determination	IMP Inferred from Mutant Phenotype more info	PubMed