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ZNF888 zinc finger protein 888 [ Homo sapiens (human) ]

Gene ID: 388559, updated on 5-Mar-2024

Summary

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Official Symbol
ZNF888provided by HGNC
Official Full Name
zinc finger protein 888provided by HGNC
Primary source
HGNC:HGNC:38695
See related
Ensembl:ENSG00000213793 AllianceGenome:HGNC:38695
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in urinary bladder (RPKM 7.4), prostate (RPKM 5.4) and 24 other tissues See more
Orthologs
all
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Genomic context

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Location:
19q13.41
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (52904415..52923428, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (55988936..56011678, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (53407668..53426681, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 468 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15057 Neighboring gene zinc finger protein 320 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:53379555-53380056 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15058 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15059 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:53425609-53426342 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:53426343-53427074 Neighboring gene ZNF816-ZNF321P readthrough Neighboring gene ZNF888 antisense RNA 1 Neighboring gene zinc finger protein 321, pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:53445795-53446619 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:53447445-53448268 Neighboring gene uncharacterized LOC124904761

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The DNA sequence and biology of human chromosome 19. Grimwood J, et al. Nature, 2004 Apr 1. PMID 15057824
  2. SMYD3 Impedes Small Cell Lung Cancer Sensitivity to Alkylation Damage through RNF113A Methylation-Phosphorylation Cross-talk. Lukinović V, et al. Cancer Discov, 2022 Sep 2. PMID 35819319, Free PMC Article
  3. Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei. Fasci D, et al. Mol Cell Proteomics, 2018 Oct. PMID 30021884, Free PMC Article
  4. Architecture of the human interactome defines protein communities and disease networks. Huttlin EL, et al. Nature, 2017 May 25. PMID 28514442, Free PMC Article
  5. Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. Huttlin EL, et al. Cell, 2021 May 27. PMID 33961781, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 888
Names
CTD-2331H12.6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001310127.2 → NP_001297056.1  zinc finger protein 888 isoform b

    See identical proteins and their annotated locations for NP_001297056.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2), as well as variant 3, encodes isoform b.
    Source sequence(s)
    AC010487
    Consensus CDS
    CCDS86801.1
    UniProtKB/Swiss-Prot
    A0A1W2PQ69, P0CJ79
    Conserved Domains (4) summary
    COG5048
    Location:324 → 708
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:300 → 320
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:7 → 48
    KRAB; KRAB box
    pfam13465
    Location:284 → 308
    zf-H2C2_2; Zinc-finger double domain

  2. NM_001384652.1 → NP_001371581.1  zinc finger protein 888 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AC010487
    Conserved Domains (4) summary
    COG5048
    Location:343 → 727
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:319 → 339
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:26 → 67
    KRAB; KRAB box
    pfam13465
    Location:303 → 327
    zf-H2C2_2; Zinc-finger double domain

  3. NM_001384653.1 → NP_001371582.1  zinc finger protein 888 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3), as well as variant 2, encodes isoform b.
    Source sequence(s)
    AC010487
    Consensus CDS
    CCDS86801.1
    UniProtKB/Swiss-Prot
    A0A1W2PQ69, P0CJ79
    Conserved Domains (4) summary
    COG5048
    Location:324 → 708
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:300 → 320
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:7 → 48
    KRAB; KRAB box
    pfam13465
    Location:284 → 308
    zf-H2C2_2; Zinc-finger double domain

  4. NM_001384654.1 → NP_001371583.1  zinc finger protein 888 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4), as well as variants 5 and 6, encodes isoform c.
    Source sequence(s)
    AC010487
    Conserved Domains (3) summary
    COG5048
    Location:288 → 672
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:264 → 284
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:248 → 272
    zf-H2C2_2; Zinc-finger double domain

  5. NM_001384655.1 → NP_001371584.1  zinc finger protein 888 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5), as well as variants 4 and 6, encodes isoform c.
    Source sequence(s)
    AC010487
    Conserved Domains (3) summary
    COG5048
    Location:288 → 672
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:264 → 284
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:248 → 272
    zf-H2C2_2; Zinc-finger double domain

  6. NM_001384656.1 → NP_001371585.1  zinc finger protein 888 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6), as well as variants 4 and 5, encodes isoform c.
    Source sequence(s)
    AC010487
    Conserved Domains (3) summary
    COG5048
    Location:288 → 672
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:264 → 284
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:248 → 272
    zf-H2C2_2; Zinc-finger double domain

  7. NM_001393938.1 → NP_001380867.1  zinc finger protein 888 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC010487
    Consensus CDS
    CCDS86801.1
    UniProtKB/Swiss-Prot
    A0A1W2PQ69, P0CJ79
    Related
    ENSP00000491567.1, ENST00000638862.2
    Conserved Domains (4) summary
    COG5048
    Location:324 → 708
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:300 → 320
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:7 → 48
    KRAB; KRAB box
    pfam13465
    Location:284 → 308
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    52904415..52923428 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047438803.1 → XP_047294759.1  zinc finger protein 888 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    55988936..56011678 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054320968.1 → XP_054176943.1  zinc finger protein 888 isoform X2

  2. XM_054320969.1 → XP_054176944.1  zinc finger protein 888 isoform X3

    UniProtKB/Swiss-Prot
    A0A1W2PQ69, P0CJ79
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P0CJ79.2 GenPept UniProtKB/Swiss-Prot:P0CJ79

Gene LinkOut

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