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KRT84 keratin 84 [ Homo sapiens (human) ]

Gene ID: 3890, updated on 7-Apr-2024

Summary

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Official Symbol
KRT84provided by HGNC
Official Full Name
keratin 84provided by HGNC
Primary source
HGNC:HGNC:6461
See related
Ensembl:ENSG00000161849 MIM:602766; AllianceGenome:HGNC:6461
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HB4; KRTHB4
Summary
The protein encoded by this gene is a member of the keratin gene family. As a type II hair keratin, it is a basic protein which heterodimerizes with type I keratins to form hair and nails. The type II hair keratins are clustered in a region of chromosome 12q13 and are grouped into two distinct subfamilies based on structure similarity. One subfamily, consisting of KRTHB1, KRTHB3, and KRTHB6, is highly related. The other less-related subfamily includes KRTHB2, KRTHB4, and KRTHB5. All hair keratins are expressed in the hair follicle; this hair keratin is contained primarily in the filiform tongue papilla, among other hair keratins. [provided by RefSeq, Jul 2008]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

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See KRT84 in Genome Data Viewer
Location:
12q13.13
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (52377812..52386977, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (52341722..52350890, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (52771596..52779436, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:52740941-52741440 Neighboring gene keratin 89, pseudogene Neighboring gene keratin 85 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:52763817-52764316 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_28991 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_28997 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_28998 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:52789485-52789986 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_29013 Neighboring gene keratin 82 Neighboring gene keratin 90, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. KRT84 is a potential tumor suppressor and good prognosis signature of oral squamous cell carcinoma. Liu Y, et al. Biosci Rep, 2020 Apr 30. PMID 32181476, Free PMC Article
  2. The complement of native alpha-keratin polypeptides of hair-forming cells: a subset of eight polypeptides that differ from epithelial cytokeratins. Heid HW, et al. Differentiation, 1986. PMID 2431943
  3. Characterization of new members of the human type II keratin gene family and a general evaluation of the keratin gene domain on chromosome 12q13.13. Rogers MA, et al. J Invest Dermatol, 2005 Mar. PMID 15737194
  4. Characterization of a 300 kbp region of human DNA containing the type II hair keratin gene domain. Rogers MA, et al. J Invest Dermatol, 2000 Mar. PMID 10692104
  5. Suppression of DDX39B sensitizes ovarian cancer cells to DNA-damaging chemotherapeutic agents via destabilizing BRCA1 mRNA. Xu Z, et al. Oncogene, 2020 Nov. PMID 32989256

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. KRT84 is a potential tumor suppressor and good prognosis signature of oral squamous cell carcinoma.
    Title: KRT84 is a potential tumor suppressor and good prognosis signature of oral squamous cell carcinoma.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables structural constituent of cytoskeleton NAS
Non-traceable Author Statement
more info
 PubMed 
enables structural constituent of skin epidermis IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in hair follicle development NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in intermediate filament organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in keratinization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nail development NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of keratinocyte differentiation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in extracellular exosome HDA PubMed 
is_active_in keratin filament IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in keratin filament IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
keratin, type II cuticular Hb4
Names
K84
hard keratin, type II, 4
keratin 84, type II
keratin, hair, basic, 4
type II hair keratin 4
type II hair keratin Hb4
type-II keratin Kb24

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012299.1 RefSeqGene

    Range
    4982..12822
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_033045.4 → NP_149034.2  keratin, type II cuticular Hb4

    See identical proteins and their annotated locations for NP_149034.2

    Status: REVIEWED

    Source sequence(s)
    AC078865, BC069647
    Consensus CDS
    CCDS8825.1
    UniProtKB/Swiss-Prot
    B2RA43, Q6ISB0, Q701L6, Q9NSB2
    Related
    ENSP00000257951.3, ENST00000257951.3
    Conserved Domains (5) summary
    pfam00038
    Location:165 → 475
    Filament; Intermediate filament protein
    pfam03980
    Location:293 → 411
    Nnf1; Nnf1
    pfam16208
    Location:16 → 161
    Keratin_2_head; Keratin type II head
    pfam16888
    Location:215 → 315
    DUF5082; Domain of unknown function (DUF5082)
    cl23720
    Location:375 → 444
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    52377812..52386977 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011538335.3 → XP_011536637.1  keratin, type II cuticular Hb4 isoform X1

    See identical proteins and their annotated locations for XP_011536637.1

    UniProtKB/Swiss-Prot
    B2RA43, Q6ISB0, Q701L6, Q9NSB2
    Conserved Domains (5) summary
    pfam00038
    Location:165 → 475
    Filament; Intermediate filament protein
    pfam03980
    Location:293 → 411
    Nnf1; Nnf1
    pfam16208
    Location:16 → 161
    Keratin_2_head; Keratin type II head
    pfam16888
    Location:215 → 315
    DUF5082; Domain of unknown function (DUF5082)
    cl23720
    Location:375 → 444
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    52341722..52350890 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054372043.1 → XP_054228018.1  keratin, type II cuticular Hb4 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9NSB2.2 GenPept UniProtKB/Swiss-Prot:Q9NSB2

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