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ARHGEF37 Rho guanine nucleotide exchange factor 37 [ Homo sapiens (human) ]

Gene ID: 389337, updated on 3-Apr-2024

Summary

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Official Symbol
ARHGEF37provided by HGNC
Official Full Name
Rho guanine nucleotide exchange factor 37provided by HGNC
Primary source
HGNC:HGNC:34430
See related
Ensembl:ENSG00000183111 MIM:620664; AllianceGenome:HGNC:34430
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in regulation of catalytic activity. Predicted to be located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in skin (RPKM 21.4), prostate (RPKM 12.5) and 20 other tissues See more
Orthologs
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Genomic context

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Location:
5q32
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (149551625..149634968)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (150086803..150169655)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (148961061..149014531)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124901105 Neighboring gene NANOG hESC enhancer GRCh37_chr5:148878477-148879023 Neighboring gene casein kinase 1 alpha 1 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_82175 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_82187 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:148920536-148920739 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:148924456-148925365 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:148927595-148928130 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr5:148929064-148930263 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23374 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23375 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:148931159-148931952 Neighboring gene ribosomal protein L29 pseudogene 14 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16498 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23378 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_82232 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23379 Neighboring gene Sharpr-MPRA regulatory region 10925 Neighboring gene RNA, U6 small nuclear 588, pseudogene Neighboring gene MPRA-validated peak5533 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23380 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23381 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23382 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr5:149011522-149012721 Neighboring gene uncharacterized LOC124901104 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_82262 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23383 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23384 Neighboring gene small nucleolar RNA U3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. ArhGEF37 assists dynamin 2 during clathrin-mediated endocytosis. Viplav A, et al. J Cell Sci, 2019 May 8. PMID 30926623, Free PMC Article
  2. Common genetic variation and antidepressant efficacy in major depressive disorder: a meta-analysis of three genome-wide pharmacogenetic studies. GENDEP Investigators, et al. Am J Psychiatry, 2013 Feb. PMID 23377640, Free PMC Article
  3. EVI1 oncoprotein interacts with a large and complex network of proteins and integrates signals through protein phosphorylation. Bard-Chapeau EA, et al. Proc Natl Acad Sci U S A, 2013 Jul 30. PMID 23858473, Free PMC Article
  4. SUMOylation of DDX39A Alters Binding and Export of Antiviral Transcripts to Control Innate Immunity. Shi P, et al. J Immunol, 2020 Jul 1. PMID 32393512
  5. Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing. Fei T, et al. Proc Natl Acad Sci U S A, 2017 Jun 27. PMID 28611215, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Common genetic variation and antidepressant efficacy in major depressive disorder: a meta-analysis of three genome-wide pharmacogenetic studies.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ41603

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
rho guanine nucleotide exchange factor 37
Names
Rho guanine nucleotide exchange factor (GEF) 37

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001001669.3 → NP_001001669.2  rho guanine nucleotide exchange factor 37

    See identical proteins and their annotated locations for NP_001001669.2

    Status: VALIDATED

    Source sequence(s)
    AC021078, AC022100, AK023814, AK123597, BC041325, BF508325, BF510234
    Consensus CDS
    CCDS43385.1
    UniProtKB/Swiss-Prot
    A1IGU5, Q6ZW51
    UniProtKB/TrEMBL
    B4DUA3
    Related
    ENSP00000328083.6, ENST00000333677.7
    Conserved Domains (4) summary
    cd07589
    Location:264 → 452
    BAR_DNMBP; The Bin/Amphiphysin/Rvs (BAR) domain of Dynamin Binding Protein
    cd11799
    Location:510 → 563
    SH3_ARHGEF37_C1; First C-terminal Src homology 3 domain of Rho guanine nucleotide exchange factor 37
    cd11941
    Location:606 → 662
    SH3_ARHGEF37_C2; Second C-terminal Src homology 3 domain of Rho guanine nucleotide exchange factor 37
    pfam00621
    Location:34 → 212
    RhoGEF; RhoGEF domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    149551625..149634968
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011537642.4 → XP_011535944.1  rho guanine nucleotide exchange factor 37 isoform X3

    UniProtKB/TrEMBL
    B4DUA3
    Conserved Domains (4) summary
    cd07589
    Location:275 → 463
    BAR_DNMBP; The Bin/Amphiphysin/Rvs (BAR) domain of Dynamin Binding Protein
    cd11799
    Location:521 → 574
    SH3_ARHGEF37_C1; First C-terminal Src homology 3 domain of Rho guanine nucleotide exchange factor 37
    cd11941
    Location:617 → 673
    SH3_ARHGEF37_C2; Second C-terminal Src homology 3 domain of Rho guanine nucleotide exchange factor 37
    pfam00621
    Location:45 → 223
    RhoGEF; RhoGEF domain

  2. XM_047417170.1 → XP_047273126.1  rho guanine nucleotide exchange factor 37 isoform X4

  3. XM_006714784.4 → XP_006714847.1  rho guanine nucleotide exchange factor 37 isoform X1

    See identical proteins and their annotated locations for XP_006714847.1

    UniProtKB/Swiss-Prot
    A1IGU5, Q6ZW51
    UniProtKB/TrEMBL
    B4DUA3
    Conserved Domains (4) summary
    cd07589
    Location:264 → 452
    BAR_DNMBP; The Bin/Amphiphysin/Rvs (BAR) domain of Dynamin Binding Protein
    cd11799
    Location:510 → 563
    SH3_ARHGEF37_C1; First C-terminal Src homology 3 domain of Rho guanine nucleotide exchange factor 37
    cd11941
    Location:606 → 662
    SH3_ARHGEF37_C2; Second C-terminal Src homology 3 domain of Rho guanine nucleotide exchange factor 37
    pfam00621
    Location:34 → 212
    RhoGEF; RhoGEF domain

  4. XM_017009460.2 → XP_016864949.1  rho guanine nucleotide exchange factor 37 isoform X2

    UniProtKB/TrEMBL
    B4DUA3

  5. XM_005268448.2 → XP_005268505.1  rho guanine nucleotide exchange factor 37 isoform X5

    Conserved Domains (3) summary
    cd07589
    Location:50 → 238
    BAR_DNMBP; The Bin/Amphiphysin/Rvs (BAR) domain of Dynamin Binding Protein
    cd11799
    Location:296 → 349
    SH3_ARHGEF37_C1; First C-terminal Src homology 3 domain of Rho guanine nucleotide exchange factor 37
    cd11941
    Location:392 → 448
    SH3_ARHGEF37_C2; Second C-terminal Src homology 3 domain of Rho guanine nucleotide exchange factor 37

  6. XM_005268447.4 → XP_005268504.1  rho guanine nucleotide exchange factor 37 isoform X1

    See identical proteins and their annotated locations for XP_005268504.1

    UniProtKB/Swiss-Prot
    A1IGU5, Q6ZW51
    UniProtKB/TrEMBL
    B4DUA3
    Conserved Domains (4) summary
    cd07589
    Location:264 → 452
    BAR_DNMBP; The Bin/Amphiphysin/Rvs (BAR) domain of Dynamin Binding Protein
    cd11799
    Location:510 → 563
    SH3_ARHGEF37_C1; First C-terminal Src homology 3 domain of Rho guanine nucleotide exchange factor 37
    cd11941
    Location:606 → 662
    SH3_ARHGEF37_C2; Second C-terminal Src homology 3 domain of Rho guanine nucleotide exchange factor 37
    pfam00621
    Location:34 → 212
    RhoGEF; RhoGEF domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    150086803..150169655
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054352571.1 → XP_054208546.1  rho guanine nucleotide exchange factor 37 isoform X3

  2. XM_054352573.1 → XP_054208548.1  rho guanine nucleotide exchange factor 37 isoform X4

  3. XM_054352569.1 → XP_054208544.1  rho guanine nucleotide exchange factor 37 isoform X1

  4. XM_054352570.1 → XP_054208545.1  rho guanine nucleotide exchange factor 37 isoform X2

  5. XM_054352574.1 → XP_054208549.1  rho guanine nucleotide exchange factor 37 isoform X5

  6. XM_054352572.1 → XP_054208547.1  rho guanine nucleotide exchange factor 37 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A1IGU5.2 GenPept UniProtKB/Swiss-Prot:A1IGU5

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