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RBM12B RNA binding motif protein 12B [ Homo sapiens (human) ]

Gene ID: 389677, updated on 7-Apr-2024

Summary

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Official Symbol
RBM12Bprovided by HGNC
Official Full Name
RNA binding motif protein 12Bprovided by HGNC
Primary source
HGNC:HGNC:32310
See related
Ensembl:ENSG00000183808 AllianceGenome:HGNC:32310
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MGC:33837
Summary
Enables RNA binding activity. Predicted to be involved in regulation of RNA splicing. Predicted to be part of ribonucleoprotein complex. Predicted to be active in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis (RPKM 5.9), ovary (RPKM 4.2) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
8q22.1
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (93728155..93741009, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (94853161..94866033, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (94740383..94753237, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene CIBAR1 divergent transcript Neighboring gene uncharacterized LOC105375641 Neighboring gene zinc finger protein 317 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27618 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:94712406-94713030 Neighboring gene CBY1 interacting BAR domain containing 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27619 Neighboring gene RBM12B antisense RNA 1 Neighboring gene RBM12B divergent transcript Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:94791793-94792322 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:94792323-94792851 Neighboring gene transmembrane protein 67

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. CEP192 interacts physically and functionally with the K63-deubiquitinase CYLD to promote mitotic spindle assembly. Gomez-Ferreria MA, et al. Cell Cycle, 2012 Oct 1. PMID 22895009, Free PMC Article
  2. The Tumor Suppressor SASH1 Interacts With the Signal Adaptor CRKL to Inhibit Epithelial-Mesenchymal Transition and Metastasis in Colorectal Cancer. Franke FC, et al. Cell Mol Gastroenterol Hepatol, 2019. PMID 30480076, Free PMC Article
  3. USP15 Deubiquitinase Safeguards Hematopoiesis and Genome Integrity in Hematopoietic Stem Cells and Leukemia Cells. van den Berk P, et al. Cell Rep, 2020 Dec 29. PMID 33378683, Free PMC Article
  4. A novel class of inhibitors that target SRSF10 and promote p53-mediated cytotoxicity on human colorectal cancer cells. Sohail M, et al. NAR Cancer, 2021 Jun. PMID 34316707, Free PMC Article
  5. Proteomic analysis reveals novel ligands and substrates for LNX1 E3 ubiquitin ligase. Lenihan JA, et al. PLoS One, 2017. PMID 29121065, Free PMC Article

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of RNA splicing IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of ribonucleoprotein complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
RNA-binding protein 12B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001377960.1 → NP_001364889.1  RNA-binding protein 12B

    Status: VALIDATED

    Source sequence(s)
    AC010834
    Consensus CDS
    CCDS43755.1
    UniProtKB/Swiss-Prot
    A8MYB5, Q8IXT5
    UniProtKB/TrEMBL
    B9ZVT1
    Related
    ENSP00000429807.2, ENST00000520560.6
    Conserved Domains (7) summary
    PTZ00121
    Location:449 → 680
    PTZ00121; MAEBL; Provisional
    PHA03321
    Location:689 → 915
    PHA03321; tegument protein VP11/12; Provisional
    cd12513
    Location:284 → 363
    RRM3_RBM12B; RNA recognition motif 3 (RRM3) found in RNA-binding protein 12B (RBM12B) and similar proteins
    cd12744
    Location:2 → 80
    RRM1_RBM12B; RNA recognition motif 1 (RRM1) found in RNA-binding protein 12B (RBM12B) and similar proteins
    cd12746
    Location:153 → 238
    RRM2_RBM12B; RNA recognition motif 2 (RRM2) found in RNA-binding protein 12B (RBM12B) and similar proteins
    cd12748
    Location:400 → 475
    RRM4_RBM12B; RNA recognition motif 4 (RRM4) found in RNA-binding protein 12B (RBM12B) and similar proteins
    cd12750
    Location:925 → 1001
    RRM5_RBM12B; RNA recognition motif 5 (RRM5) found in RNA-binding protein 12B (RBM12B) and similar proteins

  2. NM_001377961.1 → NP_001364890.1  RNA-binding protein 12B

    Status: VALIDATED

    Source sequence(s)
    AC010834
    Consensus CDS
    CCDS43755.1
    UniProtKB/Swiss-Prot
    A8MYB5, Q8IXT5
    UniProtKB/TrEMBL
    B9ZVT1
    Conserved Domains (7) summary
    PTZ00121
    Location:449 → 680
    PTZ00121; MAEBL; Provisional
    PHA03321
    Location:689 → 915
    PHA03321; tegument protein VP11/12; Provisional
    cd12513
    Location:284 → 363
    RRM3_RBM12B; RNA recognition motif 3 (RRM3) found in RNA-binding protein 12B (RBM12B) and similar proteins
    cd12744
    Location:2 → 80
    RRM1_RBM12B; RNA recognition motif 1 (RRM1) found in RNA-binding protein 12B (RBM12B) and similar proteins
    cd12746
    Location:153 → 238
    RRM2_RBM12B; RNA recognition motif 2 (RRM2) found in RNA-binding protein 12B (RBM12B) and similar proteins
    cd12748
    Location:400 → 475
    RRM4_RBM12B; RNA recognition motif 4 (RRM4) found in RNA-binding protein 12B (RBM12B) and similar proteins
    cd12750
    Location:925 → 1001
    RRM5_RBM12B; RNA recognition motif 5 (RRM5) found in RNA-binding protein 12B (RBM12B) and similar proteins

  3. NM_001377962.1 → NP_001364891.1  RNA-binding protein 12B

    Status: VALIDATED

    Source sequence(s)
    AC010834
    Consensus CDS
    CCDS43755.1
    UniProtKB/Swiss-Prot
    A8MYB5, Q8IXT5
    UniProtKB/TrEMBL
    B9ZVT1
    Conserved Domains (7) summary
    PTZ00121
    Location:449 → 680
    PTZ00121; MAEBL; Provisional
    PHA03321
    Location:689 → 915
    PHA03321; tegument protein VP11/12; Provisional
    cd12513
    Location:284 → 363
    RRM3_RBM12B; RNA recognition motif 3 (RRM3) found in RNA-binding protein 12B (RBM12B) and similar proteins
    cd12744
    Location:2 → 80
    RRM1_RBM12B; RNA recognition motif 1 (RRM1) found in RNA-binding protein 12B (RBM12B) and similar proteins
    cd12746
    Location:153 → 238
    RRM2_RBM12B; RNA recognition motif 2 (RRM2) found in RNA-binding protein 12B (RBM12B) and similar proteins
    cd12748
    Location:400 → 475
    RRM4_RBM12B; RNA recognition motif 4 (RRM4) found in RNA-binding protein 12B (RBM12B) and similar proteins
    cd12750
    Location:925 → 1001
    RRM5_RBM12B; RNA recognition motif 5 (RRM5) found in RNA-binding protein 12B (RBM12B) and similar proteins

  4. NM_001377963.1 → NP_001364892.1  RNA-binding protein 12B

    Status: VALIDATED

    Source sequence(s)
    AC010834
    Consensus CDS
    CCDS43755.1
    UniProtKB/Swiss-Prot
    A8MYB5, Q8IXT5
    UniProtKB/TrEMBL
    B9ZVT1
    Related
    ENSP00000430474.2, ENST00000519109.6
    Conserved Domains (7) summary
    PTZ00121
    Location:449 → 680
    PTZ00121; MAEBL; Provisional
    PHA03321
    Location:689 → 915
    PHA03321; tegument protein VP11/12; Provisional
    cd12513
    Location:284 → 363
    RRM3_RBM12B; RNA recognition motif 3 (RRM3) found in RNA-binding protein 12B (RBM12B) and similar proteins
    cd12744
    Location:2 → 80
    RRM1_RBM12B; RNA recognition motif 1 (RRM1) found in RNA-binding protein 12B (RBM12B) and similar proteins
    cd12746
    Location:153 → 238
    RRM2_RBM12B; RNA recognition motif 2 (RRM2) found in RNA-binding protein 12B (RBM12B) and similar proteins
    cd12748
    Location:400 → 475
    RRM4_RBM12B; RNA recognition motif 4 (RRM4) found in RNA-binding protein 12B (RBM12B) and similar proteins
    cd12750
    Location:925 → 1001
    RRM5_RBM12B; RNA recognition motif 5 (RRM5) found in RNA-binding protein 12B (RBM12B) and similar proteins

  5. NM_001377964.1 → NP_001364893.1  RNA-binding protein 12B

    Status: VALIDATED

    Source sequence(s)
    AC010834
    Consensus CDS
    CCDS43755.1
    UniProtKB/Swiss-Prot
    A8MYB5, Q8IXT5
    UniProtKB/TrEMBL
    B9ZVT1
    Conserved Domains (7) summary
    PTZ00121
    Location:449 → 680
    PTZ00121; MAEBL; Provisional
    PHA03321
    Location:689 → 915
    PHA03321; tegument protein VP11/12; Provisional
    cd12513
    Location:284 → 363
    RRM3_RBM12B; RNA recognition motif 3 (RRM3) found in RNA-binding protein 12B (RBM12B) and similar proteins
    cd12744
    Location:2 → 80
    RRM1_RBM12B; RNA recognition motif 1 (RRM1) found in RNA-binding protein 12B (RBM12B) and similar proteins
    cd12746
    Location:153 → 238
    RRM2_RBM12B; RNA recognition motif 2 (RRM2) found in RNA-binding protein 12B (RBM12B) and similar proteins
    cd12748
    Location:400 → 475
    RRM4_RBM12B; RNA recognition motif 4 (RRM4) found in RNA-binding protein 12B (RBM12B) and similar proteins
    cd12750
    Location:925 → 1001
    RRM5_RBM12B; RNA recognition motif 5 (RRM5) found in RNA-binding protein 12B (RBM12B) and similar proteins

  6. NM_203390.4 → NP_976324.2  RNA-binding protein 12B

    See identical proteins and their annotated locations for NP_976324.2

    Status: VALIDATED

    Source sequence(s)
    AC010834, BC039260
    Consensus CDS
    CCDS43755.1
    UniProtKB/Swiss-Prot
    A8MYB5, Q8IXT5
    UniProtKB/TrEMBL
    B9ZVT1
    Related
    ENSP00000382239.2, ENST00000399300.7
    Conserved Domains (7) summary
    PTZ00121
    Location:449 → 680
    PTZ00121; MAEBL; Provisional
    PHA03321
    Location:689 → 915
    PHA03321; tegument protein VP11/12; Provisional
    cd12513
    Location:284 → 363
    RRM3_RBM12B; RNA recognition motif 3 (RRM3) found in RNA-binding protein 12B (RBM12B) and similar proteins
    cd12744
    Location:2 → 80
    RRM1_RBM12B; RNA recognition motif 1 (RRM1) found in RNA-binding protein 12B (RBM12B) and similar proteins
    cd12746
    Location:153 → 238
    RRM2_RBM12B; RNA recognition motif 2 (RRM2) found in RNA-binding protein 12B (RBM12B) and similar proteins
    cd12748
    Location:400 → 475
    RRM4_RBM12B; RNA recognition motif 4 (RRM4) found in RNA-binding protein 12B (RBM12B) and similar proteins
    cd12750
    Location:925 → 1001
    RRM5_RBM12B; RNA recognition motif 5 (RRM5) found in RNA-binding protein 12B (RBM12B) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    93728155..93741009 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011517029.3 → XP_011515331.1  RNA-binding protein 12B isoform X1

    See identical proteins and their annotated locations for XP_011515331.1

    UniProtKB/Swiss-Prot
    A8MYB5, Q8IXT5
    UniProtKB/TrEMBL
    B9ZVT1
    Related
    ENSP00000428269.2, ENST00000518597.2
    Conserved Domains (7) summary
    PTZ00121
    Location:449 → 680
    PTZ00121; MAEBL; Provisional
    PHA03321
    Location:689 → 915
    PHA03321; tegument protein VP11/12; Provisional
    cd12513
    Location:284 → 363
    RRM3_RBM12B; RNA recognition motif 3 (RRM3) found in RNA-binding protein 12B (RBM12B) and similar proteins
    cd12744
    Location:2 → 80
    RRM1_RBM12B; RNA recognition motif 1 (RRM1) found in RNA-binding protein 12B (RBM12B) and similar proteins
    cd12746
    Location:153 → 238
    RRM2_RBM12B; RNA recognition motif 2 (RRM2) found in RNA-binding protein 12B (RBM12B) and similar proteins
    cd12748
    Location:400 → 475
    RRM4_RBM12B; RNA recognition motif 4 (RRM4) found in RNA-binding protein 12B (RBM12B) and similar proteins
    cd12750
    Location:925 → 1001
    RRM5_RBM12B; RNA recognition motif 5 (RRM5) found in RNA-binding protein 12B (RBM12B) and similar proteins

  2. XM_047421772.1 → XP_047277728.1  RNA-binding protein 12B isoform X1

    UniProtKB/Swiss-Prot
    A8MYB5, Q8IXT5

  3. XM_017013408.3 → XP_016868897.1  RNA-binding protein 12B isoform X1

    UniProtKB/Swiss-Prot
    A8MYB5, Q8IXT5
    UniProtKB/TrEMBL
    B9ZVT1
    Related
    ENSP00000427729.2, ENST00000517700.6
    Conserved Domains (7) summary
    PTZ00121
    Location:449 → 680
    PTZ00121; MAEBL; Provisional
    PHA03321
    Location:689 → 915
    PHA03321; tegument protein VP11/12; Provisional
    cd12513
    Location:284 → 363
    RRM3_RBM12B; RNA recognition motif 3 (RRM3) found in RNA-binding protein 12B (RBM12B) and similar proteins
    cd12744
    Location:2 → 80
    RRM1_RBM12B; RNA recognition motif 1 (RRM1) found in RNA-binding protein 12B (RBM12B) and similar proteins
    cd12746
    Location:153 → 238
    RRM2_RBM12B; RNA recognition motif 2 (RRM2) found in RNA-binding protein 12B (RBM12B) and similar proteins
    cd12748
    Location:400 → 475
    RRM4_RBM12B; RNA recognition motif 4 (RRM4) found in RNA-binding protein 12B (RBM12B) and similar proteins
    cd12750
    Location:925 → 1001
    RRM5_RBM12B; RNA recognition motif 5 (RRM5) found in RNA-binding protein 12B (RBM12B) and similar proteins

  4. XM_047421773.1 → XP_047277729.1  RNA-binding protein 12B isoform X1

    UniProtKB/Swiss-Prot
    A8MYB5, Q8IXT5

  5. XM_047421771.1 → XP_047277727.1  RNA-binding protein 12B isoform X1

    UniProtKB/Swiss-Prot
    A8MYB5, Q8IXT5

  6. XM_047421776.1 → XP_047277732.1  RNA-binding protein 12B isoform X1

    UniProtKB/Swiss-Prot
    A8MYB5, Q8IXT5

  7. XM_047421774.1 → XP_047277730.1  RNA-binding protein 12B isoform X1

    UniProtKB/Swiss-Prot
    A8MYB5, Q8IXT5

  8. XM_047421770.1 → XP_047277726.1  RNA-binding protein 12B isoform X1

    UniProtKB/Swiss-Prot
    A8MYB5, Q8IXT5

  9. XM_047421775.1 → XP_047277731.1  RNA-binding protein 12B isoform X1

    UniProtKB/Swiss-Prot
    A8MYB5, Q8IXT5

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    94853161..94866033 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054360468.1 → XP_054216443.1  RNA-binding protein 12B isoform X1

    UniProtKB/Swiss-Prot
    A8MYB5, Q8IXT5

  2. XM_054360469.1 → XP_054216444.1  RNA-binding protein 12B isoform X1

    UniProtKB/Swiss-Prot
    A8MYB5, Q8IXT5

  3. XM_054360464.1 → XP_054216439.1  RNA-binding protein 12B isoform X1

    UniProtKB/Swiss-Prot
    A8MYB5, Q8IXT5

  4. XM_054360463.1 → XP_054216438.1  RNA-binding protein 12B isoform X1

    UniProtKB/Swiss-Prot
    A8MYB5, Q8IXT5

  5. XM_054360467.1 → XP_054216442.1  RNA-binding protein 12B isoform X1

    UniProtKB/Swiss-Prot
    A8MYB5, Q8IXT5

  6. XM_054360465.1 → XP_054216440.1  RNA-binding protein 12B isoform X1

    UniProtKB/Swiss-Prot
    A8MYB5, Q8IXT5

  7. XM_054360462.1 → XP_054216437.1  RNA-binding protein 12B isoform X1

    UniProtKB/Swiss-Prot
    A8MYB5, Q8IXT5

  8. XM_054360466.1 → XP_054216441.1  RNA-binding protein 12B isoform X1

    UniProtKB/Swiss-Prot
    A8MYB5, Q8IXT5
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8IXT5.2 GenPept UniProtKB/Swiss-Prot:Q8IXT5

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