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Uch-L5 Ubiquitin carboxy-terminal hydrolase L5 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 39102, updated on 10-May-2024

Summary

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Official Symbol
Uch-L5provided by FlyBase
Official Full Name
Ubiquitin carboxy-terminal hydrolase L5provided by FlyBase
Primary source
FLYBASE:FBgn0011327
Locus tag
Dmel_CG3431
See related
AllianceGenome:FB:FBgn0011327
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA.LD24440; BcDNA:LD24440; CG3431; Dmel\CG3431; dUCH37; dUCHL5; p37A; Q9XZ61; UCH; UCH 37; uch-L3; Uch-L3; uch-l5; Uch37; uchl3; Uchl3; UCHL5
Summary
Enables thiol-dependent deubiquitinase. Involved in positive regulation of smoothened signaling pathway and protein deubiquitination. Located in cytoplasm and nucleus. Part of proteasome regulatory particle. Is expressed in adult head. Orthologous to human UCHL5 (ubiquitin C-terminal hydrolase L5). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See Uch-L5 in Genome Data Viewer
Location:
67B9-67B9; 3-29 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (9475493..9476965, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (9468593..9470065, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Jumonji, AT rich interactive domain 2 Neighboring gene pallbearer Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A new method of purification of proteasome substrates reveals polyubiquitination of 20 S proteasome subunits. Ventadour S, et al. J Biol Chem, 2007 Feb 23. PMID 17189251
  2. Drosophila Ubiquitin C-Terminal Hydrolase Knockdown Model of Parkinson's Disease. Tran HH, et al. Sci Rep, 2018 Mar 13. PMID 29535397, Free PMC Article
  3. The Deubiquitinating Enzyme UBPY Is Required for Lysosomal Biogenesis and Productive Autophagy in Drosophila. Jacomin AC, et al. PLoS One, 2015. PMID 26571504, Free PMC Article
  4. Requirement for a Drosophila E3-ubiquitin ligase in phagocytosis of apoptotic cells. Silva E, et al. Immunity, 2007 Oct. PMID 17936033
  5. The deubiquitinase UCHL5/UCH37 positively regulates Hedgehog signaling by deubiquitinating Smoothened. Zhou Z, et al. J Mol Cell Biol, 2018 Jun 1. PMID 28992318

See all (73) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. UCHL5 interacts with and deubiquitinates Smo, increasing stability and promoting accumulation at the cell membrane.
    Title: The deubiquitinase UCHL5/UCH37 positively regulates Hedgehog signaling by deubiquitinating Smoothened.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables cysteine-type deubiquitinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cysteine-type deubiquitinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables cysteine-type deubiquitinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in positive regulation of smoothened signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IC
Inferred by Curator
more info
 PubMed 
involved_in protein deubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein deubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein deubiquitination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus HDA PubMed 
part_of proteasome complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of proteasome regulatory particle IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
ubiquitin carboxy-terminal hydrolase L5
Names
CG3431-PA
CG3431-PB
Uch-L5-PA
Uch-L5-PB
ubiquitin C-terminal hydrolase
ubiquitin C-terminal hydrolase related
ubiquitin carboxy-terminal hydrolase L5 ortholog
NP_001261632.1
NP_524003.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    9475493..9476965 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_079279.3 → NP_524003.1  ubiquitin carboxy-terminal hydrolase L5, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524003.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9XZ61
    Related
    FBpp0076200
    Conserved Domains (1) summary
    cd09617
    Location:8 → 222
    Peptidase_C12_UCH37_BAP1; Cysteine peptidase C12 containing ubiquitin carboxyl-terminal hydrolase (UCH) families UCH37 (UCH-L5) and BAP1

  2. NM_001274703.1 → NP_001261632.1  ubiquitin carboxy-terminal hydrolase L5, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261632.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9XZ61
    Conserved Domains (1) summary
    cd09617
    Location:8 → 222
    Peptidase_C12_UCH37_BAP1; Cysteine peptidase C12 containing ubiquitin carboxyl-terminal hydrolase (UCH) families UCH37 (UCH-L5) and BAP1
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9XZ61 Q9XZ61

Gene LinkOut

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