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dpr10 defective proboscis extension response 10 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 39180, updated on 10-May-2024

Summary

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Official Symbol
dpr10provided by FlyBase
Official Full Name
defective proboscis extension response 10provided by FlyBase
Primary source
FLYBASE:FBgn0052057
Locus tag
Dmel_CG32057
See related
AllianceGenome:FB:FBgn0052057
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA:RE37920; CG14158; CG14159; CG32057; CT33762; Dmel\CG32057; Dpr-10; Dpr10
Summary
Involved in synapse organization. Located in neuron projection membrane. Is expressed in adult mushroom body alpha'-lobe; adult mushroom body alpha-lobe; adult mushroom body gamma-lobe; larval ventral nerve cord; and medulla. [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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See dpr10 in Genome Data Viewer
Location:
67D9-67D10; 3-32 cM
Exon count:
8
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (10147454..10186108, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (10140554..10179208, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene defective proboscis extension response 6 Neighboring gene uncharacterized protein Neighboring gene pseudo Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44538 Neighboring gene ectodermal

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Dpr10 and Nocte are required for Drosophila motor axon pathfinding. Lobb-Rabe M, et al. Neural Dev, 2022 Oct 21. PMID 36271407, Free PMC Article
  2. Transsynaptic interactions between IgSF proteins DIP-α and Dpr10 are required for motor neuron targeting specificity. Ashley J, et al. Elife, 2019 Feb 4. PMID 30714906, Free PMC Article
  3. Molecular basis of synaptic specificity by immunoglobulin superfamily receptors in Drosophila. Cheng S, et al. Elife, 2019 Jan 28. PMID 30688651, Free PMC Article
  4. Stereotyped terminal axon branching of leg motor neurons mediated by IgSF proteins DIP-α and Dpr10. Venkatasubramanian L, et al. Elife, 2019 Feb 4. PMID 30714901, Free PMC Article
  5. Affinity requirements for control of synaptic targeting and neuronal cell survival by heterophilic IgSF cell adhesion molecules. Xu S, et al. Cell Rep, 2022 Apr 5. PMID 35385751, Free PMC Article

See all (56) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. We propose a model whereby DIP-alpha and Dpr10 on opposing synaptic partners interact with each other to generate proper motor neuron connectivity.
    Title: Transsynaptic interactions between IgSF proteins DIP-α and Dpr10 are required for motor neuron targeting specificity.
  2. different leg Motor neurons depend on the DIP-alpha and Dpr10 interaction to varying degrees that correlate with the morphological complexity of the Motor neurons and their muscle targets.
    Title: Stereotyped terminal axon branching of leg motor neurons mediated by IgSF proteins DIP-α and Dpr10.
  3. These studies support an important role for the DIP/Dpr protein interaction network in regulating cell-type-specific connectivity patterns.
    Title: Interactions between the Ig-Superfamily Proteins DIP-α and Dpr6/10 Regulate Assembly of Neural Circuits.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in sensory perception of chemical stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in synapse organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in synapse organization IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
is_active_in neuron projection membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in neuron projection membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
defective proboscis extension response 10
Names
CG32057-PA
CG32057-PB
CG32057-PC
CG32057-PD
dpr10-PA
dpr10-PB
dpr10-PC
dpr10-PD

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    10147454..10186108 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_168398.2 → NP_729592.1  defective proboscis extension response 10, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_729592.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8MS24, Q9VT83
    Related
    FBpp0076038
    Conserved Domains (3) summary
    smart00408
    Location:217 → 287
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:210 → 297
    IG_like; Immunoglobulin like
    cl11960
    Location:63 → 143
    Ig; Immunoglobulin domain

  2. NM_001274747.1 → NP_001261676.1  defective proboscis extension response 10, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261676.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PF17, Q8MS24
    Conserved Domains (3) summary
    smart00408
    Location:171 → 241
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:164 → 251
    IG_like; Immunoglobulin like
    cl11960
    Location:63 → 143
    Ig; Immunoglobulin domain

  3. NM_168397.2 → NP_729591.1  defective proboscis extension response 10, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_729591.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8MS24, Q9VT83
    Related
    FBpp0076037
    Conserved Domains (3) summary
    smart00408
    Location:217 → 287
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:210 → 297
    IG_like; Immunoglobulin like
    cl11960
    Location:63 → 143
    Ig; Immunoglobulin domain

  4. NM_168399.2 → NP_729593.1  defective proboscis extension response 10, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_729593.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8MS24, Q9VT83
    Related
    FBpp0076039
    Conserved Domains (3) summary
    smart00408
    Location:217 → 287
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:210 → 297
    IG_like; Immunoglobulin like
    cl11960
    Location:63 → 143
    Ig; Immunoglobulin domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9PF17 M9PF17
Q8MS24 Q8MS24
Q9VT83 Q9VT83

Gene LinkOut

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