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Duba Deubiquitinating enzyme A [ Drosophila melanogaster (fruit fly) ]

Gene ID: 39302, updated on 10-May-2024

Summary

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Official Symbol
Dubaprovided by FlyBase
Official Full Name
Deubiquitinating enzyme Aprovided by FlyBase
Primary source
FLYBASE:FBgn0036180
Locus tag
Dmel_CG6091
See related
AllianceGenome:FB:FBgn0036180
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG6091; Dmel\CG6091; ped; Q9VTK7
Summary
Enables Lys63-specific deubiquitinase activity. Involved in negative regulation of canonical Wnt signaling pathway and sperm individualization. Is expressed in several structures, including embryonic brain; extended germ band embryo; germline cell; gonad; and larval ventral nerve cord. Orthologous to human OTUD5 (OTU deubiquitinase 5). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See Duba in Genome Data Viewer
Location:
68C15-68C15; 3-36 cM
Exon count:
8
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (11605436..11609465, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (11598536..11602565, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Mucin 68Ca

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A ubiquitin-interacting motif conserved in components of the proteasomal and lysosomal protein degradation systems. Hofmann K, et al. Trends Biochem Sci, 2001 Jun. PMID 11406394
  2. Deubiquitinase OTUD5 is a positive regulator of mTORC1 and mTORC2 signaling pathways. Cho JH, et al. Cell Death Differ, 2021 Mar. PMID 33110214, Free PMC Article
  3. The de-ubiquitylating enzyme DUBA is essential for spermatogenesis in Drosophila. Koerver L, et al. Cell Death Differ, 2016 Dec. PMID 27518434, Free PMC Article
  4. Prp8 regulates oncogene-induced hyperplastic growth in Drosophila. Fernández-Espartero CH, et al. Development, 2018 Nov 12. PMID 30333215, Free PMC Article
  5. Genome-Wide Analysis Reveals Novel Regulators of Growth in Drosophila melanogaster. Vonesch SC, et al. PLoS Genet, 2016 Jan. PMID 26751788, Free PMC Article

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. DUBA phosphorylation and catalytic activity are crucial in vivo for DUBA function in spermatogenesis.
    Title: The de-ubiquitylating enzyme DUBA is essential for spermatogenesis in Drosophila.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables K63-linked deubiquitinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables K63-linked deubiquitinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables cysteine-type deubiquitinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cysteine-type deubiquitinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in negative regulation of canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein deubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein deubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in sperm individualization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
deubiquitinating enzyme A
Names
CG6091-PD
CG6091-PE
CG6091-PF
CG6091-PG
Duba-PD
Duba-PE
Duba-PF
Duba-PG
NP_001163417.1
NP_648482.3
NP_729723.2
NP_729724.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    11605436..11609465 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_168465.5 → NP_729723.2  deubiquitinating enzyme A, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_729723.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8MQP6, Q95S49, Q9VTK7
    Conserved Domains (1) summary
    cl19932
    Location:224 → 334
    OTU; OTU-like cysteine protease

  2. NM_140225.6 → NP_648482.3  deubiquitinating enzyme A, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_648482.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8MQP6, Q95S49, Q9VTK7
    Conserved Domains (1) summary
    cl19932
    Location:224 → 334
    OTU; OTU-like cysteine protease

  3. NM_001169946.2 → NP_001163417.1  deubiquitinating enzyme A, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163417.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E1JIE7, Q95S49
    Conserved Domains (1) summary
    cl19932
    Location:224 → 334
    OTU; OTU-like cysteine protease

  4. NM_168466.4 → NP_729724.2  deubiquitinating enzyme A, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_729724.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q86NP6, Q8IQF9
    Conserved Domains (1) summary
    cl19932
    Location:64 → 174
    OTU; OTU-like cysteine protease
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
E1JIE7 E1JIE7
Q8IQF9 Q8IQF9
Q95S49 Q95S49
Q9VTK7 Q9VTK7

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