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Dph1 Diphthamide biosynthesis 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 39317, updated on 10-May-2024

Summary

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Official Symbol
Dph1provided by FlyBase
Official Full Name
Diphthamide biosynthesis 1provided by FlyBase
Primary source
FLYBASE:FBgn0036194
Locus tag
Dmel_CG11652
See related
AllianceGenome:FB:FBgn0036194
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG11652; Dmel\CG11652
Summary
Predicted to be involved in peptidyl-diphthamide biosynthetic process from peptidyl-histidine. Predicted to be located in cytoplasm. Is expressed in several structures, including anlage in statu nascendi; blastoderm embryo; extended germ band embryo; germ layer; and gut section. Orthologous to human DPH1 (diphthamide biosynthesis 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See Dph1 in Genome Data Viewer
Location:
68D2-68D2; 3-36 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (11693879..11696963, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (11686979..11690063, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR43887 Neighboring gene uncharacterized protein Neighboring gene dynein, axonemal, intermediate chain 2 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Pseudomonas exotoxin kills Drosophila S2 cells via apoptosis. Sharma AK, et al. Toxicon, 2010 Nov. PMID 20659495, Free PMC Article
  2. Forward genetic screen in human podocytes identifies diphthamide biosynthesis genes as regulators of adhesion. Cinà DP, et al. Am J Physiol Renal Physiol, 2019 Dec 1. PMID 31566424, Free PMC Article
  3. HIF-independent synthetic lethality between CDK4/6 inhibition and VHL loss across species. Nicholson HE, et al. Sci Signal, 2019 Oct 1. PMID 31575731, Free PMC Article
  4. Regulation of Drosophila hypoxia-inducible factor (HIF) activity in SL2 cells: identification of a hypoxia-induced variant isoform of the HIFalpha homolog gene similar. Gorr TA, et al. J Biol Chem, 2004 Aug 20. PMID 15169765
  5. Nutritional Control of Stem Cell Division through S-Adenosylmethionine in Drosophila Intestine. Obata F, et al. Dev Cell, 2018 Mar 26. PMID 29587144

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables 2-(3-amino-3-carboxypropyl)histidine synthase activity IEA
Inferred from Electronic Annotation
more info
  
enables 2-(3-amino-3-carboxypropyl)histidine synthase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in protein histidyl modification to diphthamide IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein histidyl modification to diphthamide IEA
Inferred from Electronic Annotation
more info
  
involved_in protein histidyl modification to diphthamide ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
diphthamide biosynthesis 1
Names
CG11652-PA
CG11652-PB
CG11652-PC
Dph1-PA
Dph1-PB
Dph1-PC
diphthamide biosynthesis-like 1
NP_001261722.1
NP_648496.1
NP_729735.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    11693879..11696963 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_140239.4 → NP_648496.1  diphthamide biosynthesis 1, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_648496.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VTM2
    Related
    FBpp0075861
    Conserved Domains (1) summary
    pfam01866
    Location:83 → 380
    Diphthamide_syn; Putative diphthamide synthesis protein

  2. NM_001274793.1 → NP_001261722.1  diphthamide biosynthesis 1, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261722.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VTM2
    Conserved Domains (1) summary
    pfam01866
    Location:83 → 380
    Diphthamide_syn; Putative diphthamide synthesis protein

  3. NM_168471.3 → NP_729735.1  diphthamide biosynthesis 1, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_729735.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VTM2
    Related
    FBpp0075862
    Conserved Domains (1) summary
    pfam01866
    Location:83 → 380
    Diphthamide_syn; Putative diphthamide synthesis protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VTM2 Q9VTM2

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