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Pi3K68D Phosphatidylinositol 3-kinase 68D [ Drosophila melanogaster (fruit fly) ]

Gene ID: 39329, updated on 10-May-2024

Summary

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Official Symbol
Pi3K68Dprovided by FlyBase
Official Full Name
Phosphatidylinositol 3-kinase 68Dprovided by FlyBase
Primary source
FLYBASE:FBgn0015278
Locus tag
Dmel_CG11621
See related
AllianceGenome:FB:FBgn0015278
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
11621; BcDNA:LD15217; CG11621; cpk; Cpk; Dmel\CG11621; dPI3k; dPI3K; dPIK; PI(3)K; Pi3K; PI3K; PI3K 68D; PI3K 68_D; PI3K-68D; PI3K-68D/E; pi3k68d; PI3K68D; PI3K_68D; PI[[3]]K
Summary
Enables several functions, including SH3 domain binding activity; phosphatidylinositol 3-kinase activity; and small GTPase binding activity. Involved in cortical actin cytoskeleton organization; negative regulation of epidermal growth factor receptor signaling pathway; and phosphatidylinositol phosphate biosynthetic process. Located in endosome membrane. Is expressed in several structures, including adult head; embryonic/larval midgut; embryonic/larval midgut primordium; and spermatozoon. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to several human genes including PIK3C2B (phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See Pi3K68D in Genome Data Viewer
Location:
68D4-68D6; 3-36 cM
Exon count:
18
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (11774650..11790013, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (11767750..11783113, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene mir-956 stem loop Neighboring gene Tim13 Neighboring gene uncharacterized protein Neighboring gene twitchy Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Using structure to define the function of phosphoinositide 3-kinase family members. Domin J, et al. FEBS Lett, 1997 Jun 23. PMID 9247130
  2. Twitchy, the Drosophila orthologue of the ciliary gating protein FBF1/dyf-19, is required for coordinated locomotion and male fertility. Hodge SH, et al. Biol Open, 2021 Aug 15. PMID 34357392, Free PMC Article
  3. Cpk is a novel class of Drosophila PtdIns 3-kinase containing a C2 domain. Molz L, et al. J Biol Chem, 1996 Jun 7. PMID 8662856
  4. Structure and function of phosphoinositide 3-kinases. Wymann MP, et al. Biochim Biophys Acta, 1998 Dec 8. PMID 9838078
  5. A family of phosphoinositide 3-kinases in Drosophila identifies a new mediator of signal transduction. MacDougall LK, et al. Curr Biol, 1995 Dec 1. PMID 8749393

See all (123) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These results highlight an unexpected crosstalk whereby the normally growth-promoting, nutrient-sensing PI3K/TOR pathway suppresses tumour formation in neural stem cells with compromised cell polarity.
    Title: Synergism between altered cortical polarity and the PI3K/TOR pathway in the suppression of tumour growth.
  2. study concludes that tumor cells become dependent on PI3K function and that reduction of PI3K activity synthetically interferes with tumor growth.
    Title: Loss of PI3K blocks cell-cycle progression in a Drosophila tumor model.
  3. evidence for a biological function for a class II PI3K by expressing this enzyme during development and by using deficiencies that remove the endogenous gene
    Title: Targeted expression of the class II phosphoinositide 3-kinase in Drosophila melanogaster reveals lipid kinase-dependent effects on patterning and interactions with receptor signaling pathways.
  4. inhibiting Inr/PI3K signaling phenocopies the cellular and organismal effects of starvation, whereas activating this pathway bypasses the nutritional requirement for cell growth, causing starvation sensitivity at the organismal level
    Title: Drosophila's insulin/PI3-kinase pathway coordinates cellular metabolism with nutritional conditions.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables 1-phosphatidylinositol-3-kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 1-phosphatidylinositol-3-kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
NOT enables 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 1-phosphatidylinositol-4-phosphate 3-kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 1-phosphatidylinositol-4-phosphate 3-kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables SH3 domain binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol binding IEA
Inferred from Electronic Annotation
more info
  
enables phospholipid binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables small GTPase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell migration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cortical actin cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of epidermal growth factor receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phosphatidylinositol phosphate biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in phosphatidylinositol phosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phosphatidylinositol-3-phosphate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phosphatidylinositol-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endosome membrane IDA
Inferred from Direct Assay
more info
 PubMed 
part_of phosphatidylinositol 3-kinase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
phosphatidylinositol 3-kinase 68D
Names
CG11621-PA
CG11621-PB
CG11621-PC
CG11621-PD
CG11621-PE
PI 3-kinase
PI3-kinase
Pi3K68D-PA
Pi3K68D-PB
Pi3K68D-PC
Pi3K68D-PD
Pi3K68D-PE
dPI 3-kinase
phosphotidylinositol 3 kinase 68D
NP_001163420.1
NP_001261724.1
NP_524028.2
NP_729743.1
NP_729745.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    11774650..11790013 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001169949.2 → NP_001163420.1  phosphatidylinositol 3-kinase 68D, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163420.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7JNX6, Q7K3H0
    Conserved Domains (7) summary
    cd06884
    Location:1611 → 1721
    PX_PI3K_C2_68D; The phosphoinositide binding Phox Homology Domain of Class II Phosphoinositide 3-Kinases similar to the Drosophila PI3K_68D protein
    cd04012
    Location:844 → 1021
    C2A_PI3K_class_II; C2 domain first repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)
    cd08381
    Location:1751 → 1871
    C2B_PI3K_class_II; C2 domain second repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)
    smart00144
    Location:561 → 669
    PI3K_rbd; PI3-kinase family, Ras-binding domain
    cd00869
    Location:1038 → 1202
    PI3Ka_II; Phosphoinositide 3-kinase (PI3K) class II, accessory domain (PIK domain); PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, class II PI3-kinases ...
    cd05166
    Location:1235 → 1583
    PI3Kc_II; Catalytic domain of Class II Phosphoinositide 3-kinase
    cl04813
    Location:58 → 392
    EIN3; Ethylene insensitive 3

  2. NM_168475.3 → NP_729743.1  phosphatidylinositol 3-kinase 68D, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_729743.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7JNX6, Q7K3H0
    Related
    FBpp0075818
    Conserved Domains (7) summary
    cd06884
    Location:1611 → 1721
    PX_PI3K_C2_68D; The phosphoinositide binding Phox Homology Domain of Class II Phosphoinositide 3-Kinases similar to the Drosophila PI3K_68D protein
    cd04012
    Location:844 → 1021
    C2A_PI3K_class_II; C2 domain first repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)
    cd08381
    Location:1751 → 1871
    C2B_PI3K_class_II; C2 domain second repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)
    smart00144
    Location:561 → 669
    PI3K_rbd; PI3-kinase family, Ras-binding domain
    cd00869
    Location:1038 → 1202
    PI3Ka_II; Phosphoinositide 3-kinase (PI3K) class II, accessory domain (PIK domain); PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, class II PI3-kinases ...
    cd05166
    Location:1235 → 1583
    PI3Kc_II; Catalytic domain of Class II Phosphoinositide 3-kinase
    cl04813
    Location:58 → 392
    EIN3; Ethylene insensitive 3

  3. NM_079304.4 → NP_524028.2  phosphatidylinositol 3-kinase 68D, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524028.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7JNX6, Q7K3H0
    Related
    FBpp0075819
    Conserved Domains (7) summary
    cd06884
    Location:1611 → 1721
    PX_PI3K_C2_68D; The phosphoinositide binding Phox Homology Domain of Class II Phosphoinositide 3-Kinases similar to the Drosophila PI3K_68D protein
    cd04012
    Location:844 → 1021
    C2A_PI3K_class_II; C2 domain first repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)
    cd08381
    Location:1751 → 1871
    C2B_PI3K_class_II; C2 domain second repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)
    smart00144
    Location:561 → 669
    PI3K_rbd; PI3-kinase family, Ras-binding domain
    cd00869
    Location:1038 → 1202
    PI3Ka_II; Phosphoinositide 3-kinase (PI3K) class II, accessory domain (PIK domain); PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, class II PI3-kinases ...
    cd05166
    Location:1235 → 1583
    PI3Kc_II; Catalytic domain of Class II Phosphoinositide 3-kinase
    cl04813
    Location:58 → 392
    EIN3; Ethylene insensitive 3

  4. NM_168476.3 → NP_729745.1  phosphatidylinositol 3-kinase 68D, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_729745.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q95RR5
    Related
    FBpp0075817
    Conserved Domains (1) summary
    cl04813
    Location:58 → 327
    EIN3; Ethylene insensitive 3

  5. NM_001274795.1 → NP_001261724.1  phosphatidylinositol 3-kinase 68D, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261724.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q95RR5
    Conserved Domains (1) summary
    cl04813
    Location:58 → 327
    EIN3; Ethylene insensitive 3
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7JNX6 Q7JNX6
Q7K3H0 Q7K3H0
Q95RR5 Q95RR5
Q9VTN5 Q9VTN5

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