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mb myoglobin [ Danio rerio (zebrafish) ]

Gene ID: 393558, updated on 31-Mar-2024

Summary

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Official Symbol
mbprovided by ZNC
Official Full Name
myoglobinprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-1430
See related
Ensembl:ENSDARG00000031952 AllianceGenome:ZFIN:ZDB-GENE-040426-1430
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:65819; zgc:77764
Summary
Predicted to enable oxygen binding activity. Acts upstream of or within several processes, including response to activity; response to hypoxia; and vasculogenesis. Is expressed in several structures, including cardiovascular system; digestive system; epithelial cell; nervous system; and pharyngeal arch. Human ortholog(s) of this gene implicated in acute kidney failure. Orthologous to human MB (myoglobin). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 1
Exon count:
4
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 1 NC_007112.7 (55137862..55145090)
105 previous assembly GRCz10 (GCF_000002035.5) 1 NC_007112.6 (54460281..54467434)

Chromosome 1 - NC_007112.7Genomic Context describing neighboring genes Neighboring gene SERTA domain containing 2a Neighboring gene RAB1A, member RAS oncogene family a Neighboring gene proliferation associated nuclear element Neighboring gene zgc:158803

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Molecular evolution of myoglobin in the Tibetan Plateau endemic schizothoracine fish (Cyprinidae, Teleostei) and tissue-specific expression changes under hypoxia. Qi D, et al. Fish Physiol Biochem, 2018 Apr. PMID 29230594
  2. Increased oxidative metabolism and myoglobin expression in zebrafish muscle during chronic hypoxia. Jaspers RT, et al. Biol Open, 2014 Jul 25. PMID 25063194, Free PMC Article
  3. A critical role for myoglobin in zebrafish development. Vlecken DH, et al. Int J Dev Biol, 2009. PMID 19378255
  4. Diverse cell-specific expression of myoglobin isoforms in brain, kidney, gill and liver of the hypoxia-tolerant carp and zebrafish. Cossins AR, et al. J Exp Biol, 2009 Mar. PMID 19218513
  5. Structural and kinetic characterization of myoglobins from eurythermal and stenothermal fish species. Madden PW, et al. Comp Biochem Physiol B Biochem Mol Biol, 2004 Mar. PMID 15050521

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Generation and validation of a myoglobin knockout zebrafish model.
    Title: Generation and validation of a myoglobin knockout zebrafish model.
  2. myoglobin plays a crucial role in zebrafish development and is important for angiogenesis and gut development
    Title: A critical role for myoglobin in zebrafish development.
  3. Cell-specific distribution of Mb within non-muscle tissues in zebrafish plays an important role in the regulation of microvascular, renal and brain function.
    Title: Diverse cell-specific expression of myoglobin isoforms in brain, kidney, gill and liver of the hypoxia-tolerant carp and zebrafish.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC65819

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables heme binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nitrite reductase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables oxygen binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables oxygen binding IEA
Inferred from Electronic Annotation
more info
  
enables oxygen carrier activity IEA
Inferred from Electronic Annotation
more info
  
enables oxygen carrier activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables peroxidase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within digestive tract development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in oxygen transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within oxygen transport IEA
Inferred from Electronic Annotation
more info
  
involved_in removal of superoxide radicals ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within response to activity IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within response to hypoxia IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within vasculogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in sarcoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
myoglobin
Names
nitrite reductase MB
pseudoperoxidase MB

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001362389.1 → NP_001349318.1  myoglobin

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. All three variants encode the same protein.
    Source sequence(s)
    CU467849, DR716512
    UniProtKB/Swiss-Prot
    Q6P028, Q6VN46
    Conserved Domains (1) summary
    cl21461
    Location:2 → 147
    Globin_like; Globin-like proteins

  2. NM_001362390.1 → NP_001349319.1  myoglobin

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.
    Source sequence(s)
    CU467849, EH493828
    UniProtKB/Swiss-Prot
    Q6P028, Q6VN46
    Conserved Domains (1) summary
    cl21461
    Location:2 → 147
    Globin_like; Globin-like proteins

  3. NM_200586.2 → NP_956880.1  myoglobin

    See identical proteins and their annotated locations for NP_956880.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.
    Source sequence(s)
    CU467849
    UniProtKB/Swiss-Prot
    Q6P028, Q6VN46
    Conserved Domains (1) summary
    cl21461
    Location:2 → 147
    Globin_like; Globin-like proteins

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007112.7 Reference GRCz11 Primary Assembly

    Range
    55137862..55145090
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005160167.4 → XP_005160224.1  myoglobin isoform X1

    UniProtKB/Swiss-Prot
    Q6VN46
    Related
    ENSDARP00000120260.1, ENSDART00000138070.3
    Conserved Domains (1) summary
    cl21461
    Location:2 → 147
    Globin_like; Globin-like proteins

  2. XM_005160168.4 → XP_005160225.1  myoglobin isoform X1

    UniProtKB/Swiss-Prot
    Q6VN46
    Related
    ENSDARP00000120315.1, ENSDART00000136378.3
    Conserved Domains (1) summary
    cl21461
    Location:2 → 147
    Globin_like; Globin-like proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6VN46.3 GenPept UniProtKB/Swiss-Prot:Q6VN46

Gene LinkOut

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