gmps guanine monophosphate synthase [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: gmpsprovided by ZNC
Official Full Name: guanine monophosphate synthaseprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-1503
See related: Ensembl:ENSDARG00000079848 AllianceGenome:ZFIN:ZDB-GENE-040426-1503
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: cb632; sb:cb632; zgc:66002; wu:fb76b01; wu:fi05a09
Summary: Predicted to enable GMP synthase activity. Predicted to be involved in GMP biosynthetic process. Predicted to act upstream of or within purine nucleotide biosynthetic process. Predicted to be active in cytosol. Is expressed in several structures, including alar plate midbrain region; digestive system; eye; midbrain; and segmental plate. Orthologous to human GMPS (guanine monophosphate synthase). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 18

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	18	NC_007129.7 (34181475..34215057)
105	previous assembly	GRCz10 (GCF_000002035.5)	18	NC_007129.6 (34205451..34239033)

Chromosome 18 - NC_007129.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fb76b01.x1 (e-PCR)
- UniSTS:191280

fi05a09.x1 (e-PCR)
- UniSTS:196666

fb76b01 (e-PCR)
- UniSTS:187505

fc19h09.x1 (e-PCR)
- UniSTS:192962

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables GMP synthase (glutamine-hydrolyzing) activity	IEA Inferred from Electronic Annotation more info
enables GMP synthase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GMP synthase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in GMP biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within GMP biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in GMP biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within glutamine metabolic process	IEA Inferred from Electronic Annotation more info
involved_in glutamine metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within purine nucleotide biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: GMP synthase [glutamine-hydrolyzing]

Names: guanine monophosphate synthetase

NP_956881.2

EC 6.3.5.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_200587.2 → NP_956881.2 GMP synthase [glutamine-hydrolyzing]

Status: PROVISIONAL

Source sequence(s)

CU570794

UniProtKB/TrEMBL

A0A8M1PBG7, B8JLW8

Related

ENSDARP00000097707.2, ENSDART00000109535.4

Conserved Domains (3) summary

cd01742
Location:27 → 206

GATase1_GMP_Synthase; Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase

PRK00074
Location:27 → 692

guaA; GMP synthase; Reviewed

cd01997
Location:237 → 691

GMP_synthase_C; The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched ...