clu clusterin [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: cluprovided by ZNC
Official Full Name: clusterinprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-1774
See related: Ensembl:ENSDARG00000010434 AllianceGenome:ZFIN:ZDB-GENE-040426-1774
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:73352
Summary: This gene encodes a protein that is similar to the human clusterin protein, a secreted chaperone that can also be found in the cell cytosol under certain stress conditions. The human protein has been suggested to be involved in several basic biological events such as cell death, tumor progression, and neurodegenerative disorders.[provided by RefSeq, May 2011]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 20

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	20	NC_007131.7 (39260608..39273884, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	20	NC_007131.6 (39357729..39371005, complement)

Chromosome 20 - NC_007131.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Zebrafish clusterin is expressed in the notochord and nervous system during development. Clusterin has also role in neuronal cell death and thus, more generally, in neurodegeneration.
Title: Induction of clusterin expression by neuronal cell death in Zebrafish.
Data show that inhibition or targeted knockdown of Notch signaling significantly increased clusterin mRNA expression in choroid plexus.
Title: The conserved clusterin gene is expressed in the developing choroid plexus under the regulation of notch but not IGF signaling in zebrafish.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables misfolded protein binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within regulation of neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: clusterin

Names: clusterin (complement lysis inhibitor, SP-40,40, sulfated glycoprotein 2, testosterone-repressed prostate message 2, apolipoprotein J)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_200802.1 → NP_957096.1 clusterin precursor

See identical proteins and their annotated locations for NP_957096.1

Status: PROVISIONAL

Source sequence(s)

BC059667

UniProtKB/TrEMBL

Q6PBL3

Related

ENSDARP00000110504.2, ENSDART00000127173.4

Conserved Domains (3) summary

smart00030
Location:24 → 217

CLb; CLUSTERIN Beta chain

smart00035
Location:233 → 440

CLa; CLUSTERIN alpha chain

pfam01093
Location:27 → 442

Clusterin; Clusterin