pafah1b3 platelet-activating factor acetylhydrolase, isoform Ib, gamma subunit [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: pafah1b3provided by ZNC
Official Full Name: platelet-activating factor acetylhydrolase, isoform Ib, gamma subunitprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-1026
See related: Ensembl:ENSDARG00000058047 AllianceGenome:ZFIN:ZDB-GENE-040426-1026
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:56430
Summary: Predicted to enable hydrolase activity. Predicted to act upstream of or within lipid catabolic process. Orthologous to human PAFAH1B3 (platelet activating factor acetylhydrolase 1b catalytic subunit 3). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 16

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	16	NC_007127.7 (11773856..11779514, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	16	NC_007127.6 (11882954..11888612, complement)

Chromosome 16 - NC_007127.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables 1-alkyl-2-acetylglycerophosphocholine esterase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables platelet-activating factor acetyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within lipid catabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: platelet-activating factor acetylhydrolase IB subunit gamma

NP_957352.1

EC 3.1.1.47

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_201058.1 → NP_957352.1 platelet-activating factor acetylhydrolase IB subunit gamma

See identical proteins and their annotated locations for NP_957352.1

Status: PROVISIONAL

Source sequence(s)

BC051609

UniProtKB/TrEMBL

A0A2R8QF79, F6NHX8, Q7ZTU4

Related

ENSDARP00000060144.3, ENSDART00000060145.5

Conserved Domains (1) summary

cd01820
Location:7 → 216

PAF_acetylesterase_like; PAF_acetylhydrolase (PAF-AH)_like subfamily of SGNH-hydrolases. Platelet-activating factor (PAF) and PAF-AH are key players in inflammation and in atherosclerosis. PAF-AH is a calcium independent phospholipase A2 which exhibits strong substrate ...