Format

Send to:

Choose Destination

hmgcs1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) [ Danio rerio (zebrafish) ]

Gene ID: 394060, updated on 3-Oct-2021

Summary

Official Symbol
hmgcs1provided by ZNC
Official Full Name
3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)provided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-1042
See related
Ensembl:ENSDARG00000103025
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:56481
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See hmgcs1 in Genome Data Viewer
Location:
chromosome: 10
Exon count:
11
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 10 NC_007121.7 (6010562..6034410)
105 previous assembly GRCz10 (GCF_000002035.5) 10 NC_007121.6 (6009381..6033201)
103 previous assembly Zv9 (GCF_000002035.4) 10 NC_007121.5 (7996234..8020026)

Chromosome 10 - NC_007121.7Genomic Context describing neighboring genes Neighboring gene serine/threonine-protein kinase pim-3-like Neighboring gene mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase Neighboring gene E3 ubiquitin-protein ligase RNF12-B-like Neighboring gene serine/threonine-protein kinase pim-2-like

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Markers

Homology

Clone Names

  • MGC56481

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables hydroxymethylglutaryl-CoA synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables hydroxymethylglutaryl-CoA synthase activity IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in acetyl-CoA metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within acetyl-CoA metabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cholesterol biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cholesterol metabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within embryonic viscerocranium morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within erythrocyte development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in farnesyl diphosphate biosynthetic process, mevalonate pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within farnesyl diphosphate biosynthetic process, mevalonate pathway IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within isoprenoid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within neural crest cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within oligodendrocyte development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within steroid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within steroid metabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within sterol biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
 

General protein information

Preferred Names
hydroxymethylglutaryl-CoA synthase, cytoplasmic
Names
3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble)
NP_957379.2
XP_005155548.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_201085.2NP_957379.2  hydroxymethylglutaryl-CoA synthase, cytoplasmic

    Status: VALIDATED

    Source sequence(s)
    BX322605
    Conserved Domains (3) summary
    TIGR01833
    Location:20477
    HMG-CoA-S_euk; 3-hydroxy-3-methylglutaryl-CoA-synthase, eukaryotic clade
    pfam01154
    Location:23193
    HMG_CoA_synt_N; Hydroxymethylglutaryl-coenzyme A synthase N terminal
    pfam08540
    Location:194477
    HMG_CoA_synt_C; Hydroxymethylglutaryl-coenzyme A synthase C terminal

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007121.7 Reference GRCz11 Primary Assembly

    Range
    6010562..6034410
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005155491.3XP_005155548.1  hydroxymethylglutaryl-CoA synthase, cytoplasmic isoform X1

    UniProtKB/TrEMBL
    A0A0R4IQG1
    Related
    ENSDARP00000145051.1, ENSDART00000190025.1
    Conserved Domains (3) summary
    TIGR01833
    Location:13470
    HMG-CoA-S_euk; 3-hydroxy-3-methylglutaryl-CoA-synthase, eukaryotic clade
    pfam01154
    Location:16186
    HMG_CoA_synt_N; Hydroxymethylglutaryl-coenzyme A synthase N terminal
    pfam08540
    Location:187470
    HMG_CoA_synt_C; Hydroxymethylglutaryl-coenzyme A synthase C terminal
Support Center