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SCaMC Short Calcium-binding Mitochondrial Carrier [ Drosophila melanogaster (fruit fly) ]

Gene ID: 39415, updated on 10-May-2024

Summary

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Official Symbol
SCaMCprovided by FlyBase
Official Full Name
Short Calcium-binding Mitochondrial Carrierprovided by FlyBase
Primary source
FLYBASE:FBgn0052103
Locus tag
Dmel_CG32103
See related
AllianceGenome:FB:FBgn0052103
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG18022; CG32103; CG4392; Dmel\CG32103
Summary
Predicted to enable ATP transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be located in mitochondrial inner membrane. Is expressed in adult head; adult heart; embryonic/larval corpus allatum; embryonic/larval fat body; and gonad. Orthologous to several human genes including SLC25A23 (solute carrier family 25 member 23) and SLC25A25 (solute carrier family 25 member 25). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See SCaMC in Genome Data Viewer
Location:
69B4-69B5; 3-38 cM
Exon count:
10
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (12402295..12414842, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (12395395..12407942, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Odorant-binding protein 69a Neighboring gene SET and MYND domain containing, class 4, member 2 Neighboring gene ADP-ribosylation factor GTPase activating protein 1 Neighboring gene twin of eyg

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A novel Drosophila mitochondrial carrier protein acts as a Mg(2+) exporter in fine-tuning mitochondrial Mg(2+) homeostasis. Cui Y, et al. Biochim Biophys Acta, 2016 Jan. PMID 26462626
  2. Evolution of Plasticity in Response to Ethanol between Sister Species with Different Ecological Histories (Drosophila melanogaster and D. simulans). Signor SA. Am Nat, 2020 Nov. PMID 33064591
  3. Functional Validation of Candidate Genes Detected by Genomic Feature Models. Rohde PD, et al. G3 (Bethesda), 2018 May 4. PMID 29519937, Free PMC Article
  4. The mitochondrial transporter SLC25A25 links ciliary TRPP2 signaling and cellular metabolism. Hofherr A, et al. PLoS Biol, 2018 Aug. PMID 30080851, Free PMC Article
  5. Drosophila melanogaster Mitochondrial Carriers: Similarities and Differences with the Human Carriers. Curcio R, et al. Int J Mol Sci, 2020 Aug 22. PMID 32842667, Free PMC Article

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in ADP transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ATP transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
short Calcium-binding mitochondrial carrier
Names
CG32103-PB
CG32103-PC
CG32103-PD
CG32103-PE
SCaMC-PB
SCaMC-PC
SCaMC-PD
SCaMC-PE

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    12402295..12414842 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_206345.2 → NP_996067.1  short Calcium-binding mitochondrial carrier, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_996067.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q0E8F2, Q8MR46
    Conserved Domains (3) summary
    COG5126
    Location:100 → 247
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    cd00051
    Location:186 → 242
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00153
    Location:375 → 463
    Mito_carr; Mitochondrial carrier protein

  2. NM_168498.1 → NP_729802.1  short Calcium-binding mitochondrial carrier, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_729802.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q0E8F2, Q8MR46
    Related
    FBpp0075714, FBtr0075982
    Conserved Domains (3) summary
    COG5126
    Location:100 → 247
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    cd00051
    Location:186 → 242
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00153
    Location:375 → 463
    Mito_carr; Mitochondrial carrier protein

  3. NM_168499.2 → NP_729803.1  short Calcium-binding mitochondrial carrier, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_729803.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VTX3
    Related
    FBpp0075715
    Conserved Domains (1) summary
    PTZ00169
    Location:70 → 339
    PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional

  4. NM_001274831.1 → NP_001261760.1  short Calcium-binding mitochondrial carrier, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261760.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PF04
    Conserved Domains (1) summary
    pfam00153
    Location:142 → 230
    Mito_carr; Mitochondrial carrier protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9PF04 M9PF04
Q0E8F2 Q0E8F2
Q8MR46 Q8MR46
Q9VTX3 Q9VTX3

Gene LinkOut

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