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ara araucan [ Drosophila melanogaster (fruit fly) ]

Gene ID: 39439, updated on 10-May-2024

Summary

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Official Symbol
araprovided by FlyBase
Official Full Name
araucanprovided by FlyBase
Primary source
FLYBASE:FBgn0015904
Locus tag
Dmel_CG10571
See related
AllianceGenome:FB:FBgn0015904
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Ara; CG10571; Dmel\CG10571; iro; Iro; iro-C; Iro-C; IRO-C; IroC
Summary
Enables DNA-binding transcription factor activity, RNA polymerase II-specific. Involved in several processes, including dendrite morphogenesis; muscle cell fate commitment; and wing disc development. Located in cytoplasm. Is expressed in several structures, including anterior-posterior subdivision of organism; extended germ band embryo; germ layer; presumptive embryonic/larval system; and transverse muscle cell. Orthologous to several human genes including IRX6 (iroquois homeobox 6). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See ara in Genome Data Viewer
Location:
69C8-69C10; 3-38 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (12580672..12596018)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (12573772..12589118)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR43612 Neighboring gene uncharacterized protein Neighboring gene Phosphomannomutase type 2 Neighboring gene sosondowah Neighboring gene caupolican Neighboring gene long non-coding RNA:CR32111

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. 2D gene expression parameters of wing imaginal disc of Drosophila for developmental analysis. Santarén JF, et al. Dev Genes Evol, 1996 Dec. PMID 24173594
  2. Iroquois transcription factors recognize a unique motif to mediate transcriptional repression in vivo. Bilioni A, et al. Proc Natl Acad Sci U S A, 2005 Oct 11. PMID 16203991, Free PMC Article
  3. Prepatterning the Drosophila notum: the three genes of the iroquois complex play intrinsically distinct roles. Ikmi A, et al. Dev Biol, 2008 May 15. PMID 18394597
  4. Apposition of iroquois expressing and non-expressing cells leads to cell sorting and fold formation in the Drosophila imaginal wing disc. Villa-Cuesta E, et al. BMC Dev Biol, 2007 Sep 19. PMID 17880703, Free PMC Article
  5. Expanding the Iroquois genes repertoire: a non-transcriptional function in cell cycle progression. Barrios N, et al. Fly (Austin), 2015. PMID 26760760, Free PMC Article

See all (192) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data show that genes araucan and caupolican as novel muscle identity genes that confer lateral transverse muscle identity, and the acquisition of this fate requires that Araucan/Caupolican repress other muscle identity genes such as slouch and vestigial.
    Title: Drosophila araucan and caupolican integrate intrinsic and signalling inputs for the acquisition by muscle progenitors of the lateral transverse fate.
  2. When caupolican and/or mirror expression is reduced, araucan loss of function has an effect on thoracic bristles development. Moreover, the overexpression of araucan is able to rescue caupolican loss of function.
    Title: Prepatterning the Drosophila notum: the three genes of the iroquois complex play intrinsically distinct roles.
  3. The data support a model in which the EGFR and Dpp signalling pathways, with their respective downstream Iro-C and tup genes, converge and cooperate to commit cells to the notum developmental fate.
    Title: tailup, a LIM-HD gene, and Iro-C cooperate in Drosophila dorsal mesothorax specification.
  4. Mutual repression between msh and Iro-C is an essential component of the boundary between body wall and wing in Drosophila.
    Title: Mutual repression between msh and Iro-C is an essential component of the boundary between body wall and wing in Drosophila.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cell development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in compound eye morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in dendrite morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in equator specification TAS
Traceable Author Statement
more info
 PubMed 
involved_in imaginal disc-derived wing morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in imaginal disc-derived wing vein specification IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in muscle cell fate commitment IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neuron differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in notum cell fate specification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of DNA-templated transcription NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IC
Inferred by Curator
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
araucan
Names
CG10571-PA
CG10571-PB
ara-PA
ara-PB
aracucan
auracan
iroquis complex
iroquois
iroquois gene complex
iroquois-complex

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    12580672..12596018
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_079321.3 → NP_524045.2  araucan, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524045.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q24248, Q9VTZ9
    Related
    FBpp0075640
    Conserved Domains (1) summary
    pfam05920
    Location:273 → 312
    Homeobox_KN; Homeobox KN domain

  2. NM_001169961.2 → NP_001163432.1  araucan, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163432.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E1JHZ0
    Conserved Domains (1) summary
    pfam05920
    Location:265 → 304
    Homeobox_KN; Homeobox KN domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
E1JHZ0 E1JHZ0
Q24248.2 Q24248
Q5U114 Q5U114
Q86NL5 Q86NL5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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