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CG8745 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 39530, updated on 4-Apr-2024

Summary

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Official Symbol
CG8745provided by FlyBase
Primary source
FLYBASE:FBgn0036381
Locus tag
Dmel_CG8745
See related
AllianceGenome:FB:FBgn0036381
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG8745
Summary
Predicted to enable ethanolamine-phosphate phospho-lyase activity. Involved in response to nicotine. Is expressed in several structures, including blastoderm embryo; embryonic/larval crystal cell; embryonic/larval fat body; extended germ band embryo; and inclusive hindgut primordium. Orthologous to several human genes including ETNPPL (ethanolamine-phosphate phospho-lyase). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
70C5-70C5; 3-41 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (13860027..13866905, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (13853127..13860005, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Tetraspanin 68C Neighboring gene Hemolectin Neighboring gene dyschronic Neighboring gene uncharacterized protein Neighboring gene Ral guanine nucleotide dissociation stimulator-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Quantitative trait transcripts for nicotine resistance in Drosophila melanogaster. Passador-Gurgel G, et al. Nat Genet, 2007 Feb. PMID 17237783
  2. Elevation of glutamine level by selenophosphate synthetase 1 knockdown induces megamitochondrial formation in Drosophila cells. Shim MS, et al. J Biol Chem, 2009 Nov 20. PMID 19755423, Free PMC Article
  3. A Quantitative Genomic Approach for Analysis of Fitness and Stress Related Traits in a Drosophila melanogaster Model Population. Duun Rohde P, et al. Int J Genomics, 2016. PMID 27274984, Free PMC Article
  4. CLOCKWORK ORANGE promotes CLOCK-CYCLE activation via the putative Drosophila ortholog of CLOCK INTERACTING PROTEIN CIRCADIAN. Rivas GBS, et al. Curr Biol, 2021 Oct 11. PMID 34331859, Free PMC Article
  5. Dynamic, mating-induced gene expression changes in female head and brain tissues of Drosophila melanogaster. Dalton JE, et al. BMC Genomics, 2010 Oct 6. PMID 20925960, Free PMC Article

See all (41) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ethanolamine-phosphate phospho-lyase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables pyridoxal phosphate binding IEA
Inferred from Electronic Annotation
more info
  
enables transaminase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in response to nicotine IEP
Inferred from Expression Pattern
more info
 PubMed 

General protein information

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Preferred Names
uncharacterized protein
Names
CG8745-PA
NP_648665.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    13860027..13866905 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_140408.3 → NP_648665.1  uncharacterized protein Dmel_CG8745 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_648665.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q95RV4, Q9VU95
    Related
    FBpp0075543
    Conserved Domains (2) summary
    cd00610
    Location:37 → 447
    OAT_like; Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase, ...
    COG0160
    Location:20 → 450
    GabT; 4-aminobutyrate aminotransferase or related aminotransferase [Amino acid transport and metabolism]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VU95.2 Q9VU95

Gene LinkOut

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