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ZP1 zona pellucida glycoprotein 1 [ Gallus gallus (chicken) ]

Gene ID: 395418, updated on 3-Apr-2024

Summary

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Official Symbol
ZP1provided by CGNC
Official Full Name
zona pellucida glycoprotein 1provided by CGNC
Primary source
CGNC:10413
See related
Ensembl:ENSGALG00010020417
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 5
Exon count:
12
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 5 NC_052536.1 (223039..228550)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 5 NC_052577.1 (216767..222318)

Chromosome 5 - NC_052536.1Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 86 Neighboring gene bile acid-CoA:amino acid N-acyltransferase Neighboring gene pre-mRNA processing factor 19 Neighboring gene transmembrane protein 109 Neighboring gene transmembrane protein 132A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification of distinctive interdomain interactions among ZP-N, ZP-C and other domains of zona pellucida glycoproteins underlying association of chicken egg-coat matrix. Okumura H, et al. FEBS Open Bio, 2015. PMID 26106520, Free PMC Article
  2. Heterocomplex formation and cell-surface accumulation of hen's serum zona pellucida B1 (ZPB1)with ZPC expressed by a mammalian cell line (COS-7): a possible initiating step of egg-envelope matrix construction. Okumura H, et al. Biol Reprod, 2007 Jan. PMID 17005939
  3. The major chicken egg envelope protein ZP1 is different from ZPB and is synthesized in the liver. Bausek N, et al. J Biol Chem, 2000 Sep 15. PMID 10979984
  4. Molecular basis of egg coat cross-linking sheds light on ZP1-associated female infertility. Nishimura K, et al. Nat Commun, 2019 Jul 12. PMID 31300655, Free PMC Article
  5. Involvement of interaction of ZP1 and ZPC in the formation of quail perivitelline membrane. Ohtsuki M, et al. Cell Tissue Res, 2004 Dec. PMID 15503149

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Study report a characterization of ZP1 proteins carrying mutations from infertile patients, which suggests that, in human, filament cross-linking by ZP1 is crucial to form a stable zona pellucida (ZP) and map the function of ZP1 to its ZP-N1 domain and determine crystal structures of ZP-N1 homodimers from a chicken homolog of ZP1.
    Title: Molecular basis of egg coat cross-linking sheds light on ZP1-associated female infertility.
  2. ZP1, in addition to ZPC, plays a major role in the initial interactions between sperm and egg.
    Title: Interaction of sperm with purified native chicken ZP1 and ZPC proteins.
  3. ZPB1-ZPC complexes accumulated on the oocyte surface act as a scaffold for subsequent matrix construction events including ZPX2 association.
    Title: Heterocomplex formation and cell-surface accumulation of hen's serum zona pellucida B1 (ZPB1)with ZPC expressed by a mammalian cell line (COS-7): a possible initiating step of egg-envelope matrix construction.
  4. Involvement in the formation of quail zona pellucida
    Title: Involvement of interaction of ZP1 and ZPC in the formation of quail perivitelline membrane.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables acrosin binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables structural constituent of egg coat IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in binding of sperm to zona pellucida IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in prevention of polyspermy IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in collagen-containing extracellular matrix IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in egg coat IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
zona pellucida sperm-binding protein 1
Names
zona pellucida glycoprotein 1 (sperm receptor)
zona pellucida protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001398046.1 → NP_001384975.1  zona pellucida sperm-binding protein 1 precursor

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000212
    Related
    ENSGALP00010029177.1, ENSGALT00010049360.1
    Conserved Domains (3) summary
    smart00018
    Location:603 → 644
    PD; P or trefoil or TFF domain
    smart00241
    Location:648 → 917
    ZP; Zona pellucida (ZP) domain
    pfam09606
    Location:178 → 525
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052536.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    223039..228550
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_040700575.2 → XP_040556509.1  zona pellucida sperm-binding protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A8V0ZD86, A0A8V0ZKP6
    Related
    ENSGALP00010029181.1, ENSGALT00010049365.1
    Conserved Domains (3) summary
    smart00018
    Location:646 → 687
    PD; P or trefoil or TFF domain
    smart00241
    Location:691 → 960
    ZP; Zona pellucida (ZP) domain
    pfam09606
    Location:221 → 568
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

  2. XM_040700576.2 → XP_040556510.1  zona pellucida sperm-binding protein 1 isoform X2

    UniProtKB/TrEMBL
    A0A140JXP0, A0A8V0ZEN8
    Related
    ENSGALP00010029192.1, ENSGALT00010049385.1
    Conserved Domains (3) summary
    smart00018
    Location:640 → 681
    PD; P or trefoil or TFF domain
    smart00241
    Location:685 → 954
    ZP; Zona pellucida (ZP) domain
    pfam09606
    Location:215 → 562
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052577.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    216767..222318
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046917695.1 → XP_046773651.1  zona pellucida sperm-binding protein 1 isoform X1

  2. XM_046917696.1 → XP_046773652.1  zona pellucida sperm-binding protein 1 isoform X2

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_204683.3: Suppressed sequence

    Description
    NM_204683.3: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein
Heading Accession and Version

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