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PCBD1 pterin-4 alpha-carbinolamine dehydratase 1 [ Gallus gallus (chicken) ]

Gene ID: 395729, updated on 5-Mar-2024

Summary

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Symbol
PCBD1provided by CGNC
Full Name
pterin-4 alpha-carbinolamine dehydratase 1provided by CGNC
Primary source
CGNC:20211
See related
Ensembl:ENSGALG00010020346
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
PCD; PHS; DCOH
Orthologs
human mouse all
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Genomic context

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See PCBD1 in Genome Data Viewer
Location:
chromosome: 6
Exon count:
4
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 6 NC_052537.1 (12329037..12333018, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 6 NC_052578.1 (12375004..12378995, complement)

Chromosome 6 - NC_052537.1Genomic Context describing neighboring genes Neighboring gene microsomal triglyceride transfer protein-like Neighboring gene sphingosine-1-phosphate lyase 1 Neighboring gene uncharacterized LOC124418060 Neighboring gene unc-5 netrin receptor B Neighboring gene solute carrier family 29 member 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential expression of chicken dimerization cofactor of hepatocyte nuclear factor-1 (DcoH) and its novel counterpart, DcoHalpha. Kim H, et al. Biochem J, 2001 Mar 15. PMID 11237869, Free PMC Article
  2. Characterization of the chicken and rat DCoH gene domains using an improved ligation-mediated PCR method. Bossow S, et al. Biol Chem, 1998 Nov. PMID 9865610
  3. Chicken genomics resource: sequencing and annotation of 35,407 ESTs from single and multiple tissue cDNA libraries and CAP3 assembly of a chicken gene index. Carre W, et al. Physiol Genomics, 2006 May 16. PMID 16554550
  4. A comprehensive collection of chicken cDNAs. Boardman PE, et al. Curr Biol, 2002 Nov 19. PMID 12445392
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables 4-alpha-hydroxytetrahydrobiopterin dehydratase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in tetrahydrobiopterin biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
pterin-4-alpha-carbinolamine dehydratase
Names
4-alpha-hydroxy-tetrahydropterin dehydratase
6-pyruvoyl-tetrahydropterin synthase
cDcoH
dimerization cofactor of HNF1
dimerization cofactor of hepatocyte nuclear factor 1-alpha
phenylalanine hydroxylase-stimulating protein
pterin carbinolamine dehydratase
pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1)
NP_990236.1
XP_046775862.1
XP_046798685.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_204905.2 → NP_990236.1  pterin-4-alpha-carbinolamine dehydratase

    See identical proteins and their annotated locations for NP_990236.1

    Status: VALIDATED

    Source sequence(s)
    BM490804, BU422064
    UniProtKB/Swiss-Prot
    O73930
    UniProtKB/TrEMBL
    A0A8V0ZDX6
    Related
    ENSGALP00010029058.1, ENSGALT00010049148.1
    Conserved Domains (1) summary
    cd00914
    Location:24 → 99
    PCD_DCoH_subfamily_b; PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by ...

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052537.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    12329037..12333018 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046942729.1 → XP_046798685.1  pterin-4-alpha-carbinolamine dehydratase isoform X1

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052578.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    12375004..12378995 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046919906.1 → XP_046775862.1  pterin-4-alpha-carbinolamine dehydratase isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O73930.3 GenPept UniProtKB/Swiss-Prot:O73930

Gene LinkOut

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