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SHC1 SHC adaptor protein 1 [ Gallus gallus (chicken) ]

Gene ID: 395934, updated on 11-Apr-2024

Summary

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Symbol
SHC1provided by CGNC
Full Name
SHC adaptor protein 1provided by CGNC
Primary source
CGNC:5182
See related
Ensembl:ENSGALG00010027922
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
SHC
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 25
Exon count:
18
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 25 NC_052556.1 (2019483..2029642, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 25 NC_052597.1 (2145300..2155438, complement)

Chromosome 25 - NC_052556.1Genomic Context describing neighboring genes Neighboring gene PBX homeobox interacting protein 1 Neighboring gene pygopus family PHD finger 2 Neighboring gene CDC28 protein kinase regulatory subunit 1B Neighboring gene flavin adenine dinucleotide synthetase 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Effect of nutritional state on the formation of a complex involving insulin receptor IRS-1, the 52 kDa Src homology/collagen protein (Shc) isoform and phosphatidylinositol 3'-kinase activity. Dupont J, et al. Biochem J, 1998 Oct 15. PMID 9761726, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables receptor tyrosine kinase binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell surface receptor protein tyrosine kinase signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
SHC-transforming protein 1
Names
SHC (Src homology 2 domain containing) transforming protein 1
adaptor protein SHC

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001293280.4 → NP_001280209.1  SHC-transforming protein 1 isoform a

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000351
    UniProtKB/TrEMBL
    A0A1D5NYP8
    Related
    ENSGALP00010041423.1, ENSGALT00010067680.1
    Conserved Domains (2) summary
    cd09925
    Location:523 → 626
    SH2_SHC; Src homology 2 (SH2) domain found in SH2 adaptor protein C (SHC)
    cd01209
    Location:182 → 353
    PTB_Shc; Shc-like phosphotyrosine-binding (PTB) domain

  2. NM_001397586.1 → NP_001384515.1  SHC-transforming protein 1 isoform b

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000351
    Conserved Domains (2) summary
    cd09925
    Location:522 → 625
    SH2_SHC; Src homology 2 (SH2) domain found in SH2 adaptor protein C (SHC)
    cd01209
    Location:182 → 353
    PTB_Shc; Shc-like phosphotyrosine-binding (PTB) domain

  3. NM_001397587.1 → NP_001384516.1  SHC-transforming protein 1 isoform c

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000351
    UniProtKB/TrEMBL
    A0A8V1A684
    Related
    ENSGALP00010041429.1, ENSGALT00010067686.1
    Conserved Domains (2) summary
    cd09925
    Location:389 → 492
    SH2_SHC; Src homology 2 (SH2) domain found in SH2 adaptor protein C (SHC)
    cd01209
    Location:48 → 219
    PTB_Shc; Shc-like phosphotyrosine-binding (PTB) domain

  4. NM_001397588.1 → NP_001384517.1  SHC-transforming protein 1 isoform c

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000351
    UniProtKB/TrEMBL
    A0A8V1A684
    Conserved Domains (2) summary
    cd09925
    Location:389 → 492
    SH2_SHC; Src homology 2 (SH2) domain found in SH2 adaptor protein C (SHC)
    cd01209
    Location:48 → 219
    PTB_Shc; Shc-like phosphotyrosine-binding (PTB) domain

  5. NM_001397589.1 → NP_001384518.1  SHC-transforming protein 1 isoform d

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000351
    Related
    ENSGALP00010041424.1, ENSGALT00010067681.1
    Conserved Domains (2) summary
    cd09925
    Location:375 → 478
    SH2_SHC; Src homology 2 (SH2) domain found in SH2 adaptor protein C (SHC)
    cd01209
    Location:34 → 205
    PTB_Shc; Shc-like phosphotyrosine-binding (PTB) domain

  6. NM_001397590.1 → NP_001384519.1  SHC-transforming protein 1 isoform d

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000351
    Conserved Domains (2) summary
    cd09925
    Location:375 → 478
    SH2_SHC; Src homology 2 (SH2) domain found in SH2 adaptor protein C (SHC)
    cd01209
    Location:34 → 205
    PTB_Shc; Shc-like phosphotyrosine-binding (PTB) domain

  7. NM_001397591.1 → NP_001384520.1  SHC-transforming protein 1 isoform d

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000351
    Conserved Domains (2) summary
    cd09925
    Location:375 → 478
    SH2_SHC; Src homology 2 (SH2) domain found in SH2 adaptor protein C (SHC)
    cd01209
    Location:34 → 205
    PTB_Shc; Shc-like phosphotyrosine-binding (PTB) domain

  8. NM_001397592.1 → NP_001384521.1  SHC-transforming protein 1 isoform d

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000351
    Conserved Domains (2) summary
    cd09925
    Location:375 → 478
    SH2_SHC; Src homology 2 (SH2) domain found in SH2 adaptor protein C (SHC)
    cd01209
    Location:34 → 205
    PTB_Shc; Shc-like phosphotyrosine-binding (PTB) domain

  9. NM_001397593.1 → NP_001384522.1  SHC-transforming protein 1 isoform e

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000351
    Conserved Domains (2) summary
    cd09925
    Location:374 → 477
    SH2_SHC; Src homology 2 (SH2) domain found in SH2 adaptor protein C (SHC)
    cd01209
    Location:34 → 205
    PTB_Shc; Shc-like phosphotyrosine-binding (PTB) domain

  10. NM_001397594.1 → NP_001384523.1  SHC-transforming protein 1 isoform e

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000351
    Conserved Domains (2) summary
    cd09925
    Location:374 → 477
    SH2_SHC; Src homology 2 (SH2) domain found in SH2 adaptor protein C (SHC)
    cd01209
    Location:34 → 205
    PTB_Shc; Shc-like phosphotyrosine-binding (PTB) domain

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052556.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    2019483..2029642 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015298489.4 → XP_015153975.1  SHC-transforming protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A8V1A680
    Conserved Domains (2) summary
    cd09925
    Location:388 → 491
    SH2_SHC; Src homology 2 (SH2) domain found in SH2 adaptor protein C (SHC)
    cd01209
    Location:48 → 219
    PTB_Shc; Shc-like phosphotyrosine-binding (PTB) domain

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052597.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    2145300..2155438 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046932557.1 → XP_046788513.1  SHC-transforming protein 1 isoform X1

Nucleotide Protein Strain
Heading Accession and Version

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