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FGF1 fibroblast growth factor 1 [ Gallus gallus (chicken) ]

Gene ID: 396094, updated on 5-Mar-2024

Summary

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Symbol
FGF1provided by CGNC
Full Name
fibroblast growth factor 1provided by CGNC
Primary source
CGNC:5548
See related
Ensembl:ENSGALG00010013399
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
ECGF; FGF-1
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 13
Exon count:
7
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 13 NC_052544.1 (16864396..16880265, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 13 NC_052585.1 (16876570..16892410, complement)

Chromosome 13 - NC_052544.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101749811 Neighboring gene sprouty RTK signaling antagonist 4 Neighboring gene uncharacterized LOC121106695 Neighboring gene Rho GTPase activating protein 26 Neighboring gene nuclear receptor subfamily 3 group C member 1 Neighboring gene microRNA 6588

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cloning of multiple chicken FGF1 mRNAs and their differential expression during development of whole embryo and of the lens. Philippe JM, et al. DNA Cell Biol, 1996 Sep. PMID 8836029
  2. Endothelial cell growth factors in embryonic and adult chick brain are related to human acidic fibroblast growth factor. Risau W, et al. EMBO J, 1988 Apr. PMID 3402441, Free PMC Article
  3. Differentiating and mature neurons express the acidic fibroblast growth factor gene during chick neural development. Schnürch H, et al. Development, 1991 Apr. PMID 1715259
  4. Expression profiles and associations of FGF1 and FGF10 with intramuscular fat in Tibetan chicken. Zhang R, et al. Br Poult Sci, 2018 Dec. PMID 30259763
  5. Fibroblast growth factor (FGF) signaling during gastrulation negatively modulates the abundance of microRNAs that regulate proteins required for cell migration and embryo patterning. Bobbs AS, et al. J Biol Chem, 2012 Nov 9. PMID 22995917, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. results provide a basis for functional elucidation of fibroblast growth factor 1 and fibroblast growth factor 10 genes on adipocyte development and intramuscular fat deposition
    Title: Expression profiles and associations of FGF1 and FGF10 with intramuscular fat in Tibetan chicken.
  2. FGF signaling regulates gene expression by negatively modulating microRNA abundance through both LIN28B-dependent and LIN28B-independent pathways
    Title: Fibroblast growth factor (FGF) signaling during gastrulation negatively modulates the abundance of microRNAs that regulate proteins required for cell migration and embryo patterning.
  3. Fibroblast growth factor and bone morphogenetic protein signaling are required for specifying prechondrogenic identity in neural crest-derived mesenchyme and initiating the chondrogenic program.
    Title: Fibroblast growth factor and bone morphogenetic protein signaling are required for specifying prechondrogenic identity in neural crest-derived mesenchyme and initiating the chondrogenic program.
  4. FGF-1-stimulated angiogenesis in vivo in influenced by PKB/AKT signaling
    Title: Role of AKT/PKB signaling in fibroblast growth factor-1 (FGF-1)-induced angiogenesis in the chicken chorioallantoic membrane (CAM).
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables fibroblast growth factor receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables growth factor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in animal organ morphogenesis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in fibroblast growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of gene expression IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of cell migration IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
fibroblast growth factor 1
Names
HBGF-1
aFGF
acidic fibroblast growth factor, aFGF
alpha-endothelial cell growth factor
endothelial cell growth factor
fibroblast growth factor 1 (acidic)
heparin-binding growth factor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_205180.2 → NP_990511.1  fibroblast growth factor 1

    See identical proteins and their annotated locations for NP_990511.1

    Status: PROVISIONAL

    Source sequence(s)
    JAENSK010000256
    UniProtKB/Swiss-Prot
    P19596
    UniProtKB/TrEMBL
    A0A2L2DDN9
    Conserved Domains (1) summary
    pfam00167
    Location:25 → 148
    FGF; Fibroblast growth factor

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052544.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    16864396..16880265 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015294011.3 → XP_015149497.1  fibroblast growth factor 1 isoform X2

    Conserved Domains (1) summary
    pfam00167
    Location:25 → 147
    FGF; Fibroblast growth factor

  2. XM_015294009.4 → XP_015149495.1  fibroblast growth factor 1 isoform X1

    UniProtKB/Swiss-Prot
    P19596
    UniProtKB/TrEMBL
    A0A2L2DDN9
    Conserved Domains (1) summary
    pfam00167
    Location:25 → 148
    FGF; Fibroblast growth factor

  3. XM_040646857.2 → XP_040502791.1  fibroblast growth factor 1 isoform X1

    UniProtKB/Swiss-Prot
    P19596
    UniProtKB/TrEMBL
    A0A2L2DDN9
    Conserved Domains (1) summary
    pfam00167
    Location:25 → 148
    FGF; Fibroblast growth factor

  4. XM_015294010.4 → XP_015149496.1  fibroblast growth factor 1 isoform X1

    UniProtKB/Swiss-Prot
    P19596
    UniProtKB/TrEMBL
    A0A2L2DDN9
    Conserved Domains (1) summary
    pfam00167
    Location:25 → 148
    FGF; Fibroblast growth factor

  5. XM_046900309.1 → XP_046756265.1  fibroblast growth factor 1 isoform X2

  6. XM_040646856.2 → XP_040502790.1  fibroblast growth factor 1 isoform X1

    UniProtKB/Swiss-Prot
    P19596
    UniProtKB/TrEMBL
    A0A2L2DDN9
    Conserved Domains (1) summary
    pfam00167
    Location:25 → 148
    FGF; Fibroblast growth factor

  7. XM_025154815.3 → XP_025010583.1  fibroblast growth factor 1 isoform X2

    Conserved Domains (1) summary
    pfam00167
    Location:25 → 147
    FGF; Fibroblast growth factor

  8. XM_025154816.3 → XP_025010584.1  fibroblast growth factor 1 isoform X2

    Conserved Domains (1) summary
    pfam00167
    Location:25 → 147
    FGF; Fibroblast growth factor

  9. XM_025154814.3 → XP_025010582.1  fibroblast growth factor 1 isoform X1

    UniProtKB/Swiss-Prot
    P19596
    UniProtKB/TrEMBL
    A0A2L2DDN9
    Related
    ENSGALP00010019052.1, ENSGALT00010032262.1
    Conserved Domains (1) summary
    pfam00167
    Location:25 → 148
    FGF; Fibroblast growth factor

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052585.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    16876570..16892410 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046926867.1 → XP_046782823.1  fibroblast growth factor 1 isoform X2

  2. XM_046926862.1 → XP_046782818.1  fibroblast growth factor 1 isoform X1

    UniProtKB/Swiss-Prot
    P19596
    UniProtKB/TrEMBL
    A0A2L2DDN9

  3. XM_046926866.1 → XP_046782822.1  fibroblast growth factor 1 isoform X1

    UniProtKB/Swiss-Prot
    P19596
    UniProtKB/TrEMBL
    A0A2L2DDN9

  4. XM_046926865.1 → XP_046782821.1  fibroblast growth factor 1 isoform X1

    UniProtKB/Swiss-Prot
    P19596
    UniProtKB/TrEMBL
    A0A2L2DDN9

  5. XM_046926869.1 → XP_046782825.1  fibroblast growth factor 1 isoform X2

  6. XM_046926864.1 → XP_046782820.1  fibroblast growth factor 1 isoform X1

    UniProtKB/Swiss-Prot
    P19596
    UniProtKB/TrEMBL
    A0A2L2DDN9

  7. XM_046926868.1 → XP_046782824.1  fibroblast growth factor 1 isoform X2

  8. XM_046926870.1 → XP_046782826.1  fibroblast growth factor 1 isoform X2

  9. XM_046926863.1 → XP_046782819.1  fibroblast growth factor 1 isoform X1

    UniProtKB/Swiss-Prot
    P19596
    UniProtKB/TrEMBL
    A0A2L2DDN9
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P19596.2 GenPept UniProtKB/Swiss-Prot:P19596

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