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TNR tenascin R [ Gallus gallus (chicken) ]

Gene ID: 396213, updated on 3-Apr-2024

Summary

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Symbol
TNRprovided by CGNC
Full Name
tenascin Rprovided by CGNC
Primary source
CGNC:3344
See related
Ensembl:ENSGALG00010010099
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
tenascin-R
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 8
Exon count:
22
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 8 NC_052539.1 (7008602..7060534)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 8 NC_052580.1 (7019963..7072027)

Chromosome 8 - NC_052539.1Genomic Context describing neighboring genes Neighboring gene pappalysin 2 Neighboring gene ring finger and WD repeat domain 2 Neighboring gene small Cajal body-specific RNA 3 Neighboring gene KIAA0040 Neighboring gene tenascin N

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The chicken neural extracellular matrix molecule restrictin: similarity with EGF-, fibronectin type III-, and fibrinogen-like motifs. Nörenberg U, et al. Neuron, 1992 May. PMID 1375037
  2. Characterization of functional domains of the tenascin-R (restrictin) polypeptide: cell attachment site, binding with F11, and enhancement of F11-mediated neurite outgrowth by tenascin-R. Nörenberg U, et al. J Cell Biol, 1995 Jul. PMID 7615642, Free PMC Article
  3. Dissection of complex molecular interactions of neurofascin with axonin-1, F11, and tenascin-R, which promote attachment and neurite formation of tectal cells. Volkmer H, et al. J Cell Biol, 1998 Aug 24. PMID 9722619, Free PMC Article
  4. Chicken acidic leucine-rich EGF-like domain containing brain protein (CALEB), a neural member of the EGF family of differentiation factors, is implicated in neurite formation. Schumacher S, et al. J Cell Biol, 1997 Feb 24. PMID 9049254, Free PMC Article
  5. CALEB binds via its acidic stretch to the fibrinogen-like domain of tenascin-C or tenascin-R and its expression is dynamically regulated after optic nerve lesion. Schumacher S, et al. J Biol Chem, 2001 Mar 9. PMID 11069908

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
tenascin-R
Names
TN-R
restrictin
tenascin R (restrictin, janusin)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_205276.4 → NP_990607.3  tenascin-R precursor

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000237
    UniProtKB/Swiss-Prot
    Q00546
    Conserved Domains (4) summary
    smart00060
    Location:686 → 762
    FN3; Fibronectin type 3 domain
    smart00186
    Location:1130 → 1338
    FBG; Fibrinogen-related domains (FReDs)
    cd00063
    Location:327 → 412
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam18720
    Location:203 → 230
    EGF_Tenascin; Tenascin EGF domain

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052539.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    7008602..7060534
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015290244.4 → XP_015145730.1  tenascin-R isoform X1

    UniProtKB/Swiss-Prot
    Q00546
    Related
    ENSGALP00010013686.1, ENSGALT00010023992.1
    Conserved Domains (6) summary
    smart00060
    Location:1039 → 1108
    FN3; Fibronectin type 3 domain
    smart00186
    Location:1132 → 1340
    FBG; Fibrinogen-related domains (FReDs)
    cd00063
    Location:327 → 412
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:686 → 758
    fn3; Fibronectin type III domain
    pfam00757
    Location:203 → 286
    Furin-like; Furin-like cysteine rich region
    pfam07974
    Location:297 → 322
    EGF_2; EGF-like domain

  2. XM_015290245.4 → XP_015145731.1  tenascin-R isoform X2

    UniProtKB/Swiss-Prot
    Q00546
    UniProtKB/TrEMBL
    A0A8V0XZF7
    Related
    ENSGALP00010013690.1, ENSGALT00010024004.1
    Conserved Domains (6) summary
    smart00060
    Location:994 → 1063
    FN3; Fibronectin type 3 domain
    smart00186
    Location:1087 → 1295
    FBG; Fibrinogen-related domains (FReDs)
    cd00063
    Location:282 → 367
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:641 → 713
    fn3; Fibronectin type III domain
    pfam00757
    Location:158 → 241
    Furin-like; Furin-like cysteine rich region
    pfam07974
    Location:252 → 277
    EGF_2; EGF-like domain

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052580.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    7019963..7072027
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046922395.1 → XP_046778351.1  tenascin-R isoform X1

  2. XM_046922396.1 → XP_046778352.1  tenascin-R isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q00546.1 GenPept UniProtKB/Swiss-Prot:Q00546

Gene LinkOut

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