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TTR transthyretin [ Gallus gallus (chicken) ]

Gene ID: 396277, updated on 5-Mar-2024

Summary

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Official Symbol
TTRprovided by CGNC
Official Full Name
transthyretinprovided by CGNC
Primary source
CGNC:49731
See related
Ensembl:ENSGALG00010006069
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 2
Exon count:
5
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 2 NC_052533.1 (105791008..105800067)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 2 NC_052574.1 (105860150..105869209)

Chromosome 2 - NC_052533.1Genomic Context describing neighboring genes Neighboring gene desmoglein 4 Neighboring gene uncharacterized LOC107052701 Neighboring gene desmoglein 2 Neighboring gene transthyretin-like Neighboring gene beta-1,4-galactosyltransferase 6 Neighboring gene opsin 5-like 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The affinity of transthyretin for T(3) or T(4) does not determine which form of the hormone accumulates in the choroid plexus. Richardson SJ, et al. Gen Comp Endocrinol, 2018 Aug 1. PMID 28919452
  2. Photostimulated expression of type 2 iodothyronine deiodinase mRNA is greatly attenuated in the rostral tuberal hypothalamus of the photorefractory turkey hen. Steinman MQ, et al. J Neuroendocrinol, 2008 Nov. PMID 18752654
  3. Interaction of diethylstilbestrol and ioxynil with transthyretin in chicken serum. Eguchi R, et al. Comp Biochem Physiol C Toxicol Pharmacol, 2008 Apr. PMID 18243807
  4. The crystal structure of transthyretin from chicken. Sunde M, et al. Eur J Biochem, 1996 Mar 1. PMID 8612621
  5. Isolation, characterization, cDNA cloning and gene expression of an avian transthyretin. Implications for the evolution of structure and function of transthyretin in vertebrates. Duan W, et al. Eur J Biochem, 1991 Sep 15. PMID 1833190

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TTR, Deiodinase 3 and OATP1C1 expression were found to be highly concentrated in the choroid plexus.
    Title: The affinity of transthyretin for T(3) or T(4) does not determine which form of the hormone accumulates in the choroid plexus.
  2. Difference in triiodophenol(TIP) binding between female and male chickens; females bind less TIP than male adult and juvenile chickens.
    Title: Characterization of plasma triiodophenol binding proteins in vertebrates and tissue distribution of triiodophenol in Rana catesbeiana tadpoles.
  3. Significant amount of diethylstilbestrol and ioxynil interacted with TTR in whole chicken serum.
    Title: Interaction of diethylstilbestrol and ioxynil with transthyretin in chicken serum.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables thyroid hormone binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in purine nucleobase metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
transthyretin
Names
TBPA
prealbumin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001281498.1 → NP_001268427.1  transthyretin isoform 2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding region compared to variant 1. The resulting protein (isoform 2) has a longer N-terminus compared to isoform 1.
    Source sequence(s)
    BU119521, BU352734, CR407350
    UniProtKB/TrEMBL
    A0A1I7Q422, A0A8V0XRG8
    Related
    ENSGALP00010008537.1, ENSGALT00010014520.1
    Conserved Domains (1) summary
    smart00095
    Location:48 → 168
    TR_THY; Transthyretin

  2. NM_205335.3 → NP_990666.1  transthyretin isoform 1 precursor

    See identical proteins and their annotated locations for NP_990666.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript and encodes the shorter protein (isoform 1).
    Source sequence(s)
    BU269372, BU339400, BU352734, DN851840, X60471
    UniProtKB/Swiss-Prot
    P27731
    UniProtKB/TrEMBL
    A0A8V0XRG8
    Related
    ENSGALP00010008532.1, ENSGALT00010014515.1
    Conserved Domains (1) summary
    smart00095
    Location:30 → 150
    TR_THY; Transthyretin

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052533.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    105791008..105800067
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052574.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    105860150..105869209
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P27731.1 GenPept UniProtKB/Swiss-Prot:P27731

Gene LinkOut

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