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TNNC2 troponin C2, fast skeletal type [ Gallus gallus (chicken) ]

Gene ID: 396434, updated on 5-Mar-2024

Summary

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Symbol
TNNC2provided by CGNC
Full Name
troponin C2, fast skeletal typeprovided by CGNC
Primary source
CGNC:49802
See related
Ensembl:ENSGALG00010015909
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs
human mouse all
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Genomic context

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See TNNC2 in Genome Data Viewer
Location:
chromosome: 20
Exon count:
6
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 20 NC_052551.1 (10853101..10854914, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 20 NC_052592.1 (10640531..10642344, complement)

Chromosome 20 - NC_052551.1Genomic Context describing neighboring genes Neighboring gene ubiquitin conjugating enzyme E2 U (putative) Neighboring gene uncharacterized LOC107054848 Neighboring gene sorting nexin family member 21 Neighboring gene acyl-CoA thioesterase 8

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Conformation of the troponin core complex in the thin filaments of skeletal muscle during relaxation and active contraction. Knowles AC, et al. J Mol Biol, 2012 Aug 3. PMID 22579625
  2. Fast pressure jumps can perturb calcium and magnesium binding to troponin C F29W. Pearson DS, et al. Biochemistry, 2008 Nov 18. PMID 18942859, Free PMC Article
  3. Structure of chicken skeletal muscle troponin C at 1.78 A resolution. Satyshur KA, et al. Acta Crystallogr D Biol Crystallogr, 1994 Jan 1. PMID 15299475
  4. Low-temperature-induced structural changes in the Apo regulatory domain of skeletal muscle troponin C. Tsuda S, et al. Biochemistry, 1999 May 4. PMID 10231519
  5. Structural details of a calcium-induced molecular switch: X-ray crystallographic analysis of the calcium-saturated N-terminal domain of troponin C at 1.75 A resolution. Strynadka NC, et al. J Mol Biol, 1997 Oct 17. PMID 9367759

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A model of the orientation of the C-terminal lobe of troponin C (TnC) in skeletal muscle.
    Title: Conformation of the troponin core complex in the thin filaments of skeletal muscle during relaxation and active contraction.
  2. Fast pressure jumps can perturb calcium and magnesium binding to troponin C F29W.(
    Title: Fast pressure jumps can perturb calcium and magnesium binding to troponin C F29W.
  3. Results describe the solution structures of a "mobile" actin-binding domain (approximately 6.1 kDa) in the troponin ternary complex.
    Title: Structural basis for Ca2+-regulated muscle relaxation at interaction sites of troponin with actin and tropomyosin.
  4. Data show that a recombinant troponin C/calmodulin chimera, in which the carboxyl-terminal domain of TnC is replaced by that of CaM, has the same ability as CaM to bind and transmit the signal to calcium sites on the enzyme.
    Title: Troponin C/calmodulin chimeras as erythrocyte plasma membrane Ca2+-ATPase activators.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of myosin II complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
troponin C, skeletal muscle
Names
troponin C (TNC)
troponin C type 2 (fast)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_205450.3 → NP_990781.2  troponin C, skeletal muscle

    Status: PROVISIONAL

    Source sequence(s)
    JAENSK010000328
    UniProtKB/Swiss-Prot
    P02588
    UniProtKB/TrEMBL
    A0A8V0Z0J1
    Related
    ENSGALP00010022150.1, ENSGALT00010038335.1
    Conserved Domains (1) summary
    PTZ00184
    Location:15 → 159
    PTZ00184; calmodulin; Provisional

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052551.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    10853101..10854914 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052592.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    10640531..10642344 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P02588.3 GenPept UniProtKB/Swiss-Prot:P02588

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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Research Materials
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