TNC tenascin C [Gallus gallus (chicken)] - Gene

Summary

Official Symbol: TNCprovided by CGNC
Official Full Name: tenascin Cprovided by CGNC
Primary source: CGNC:49806
See related: Ensembl:ENSGALG00010028900
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as: JI; TN; GMEM; TN-C
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 17

Exon count:: 35

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	17	NC_052548.1 (3320835..3419298, complement)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	17	NC_052589.1 (2729605..2885544, complement)

Chromosome 17 - NC_052548.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Developmental Changes in Patterns of Distribution of Fibronectin and Tenascin-C in the Chicken Cornea: Evidence for Distinct and Independent Functions during Corneal Development and Morphogenesis.
Title: Developmental Changes in Patterns of Distribution of Fibronectin and Tenascin-C in the Chicken Cornea: Evidence for Distinct and Independent Functions during Corneal Development and Morphogenesis.
Gain-of-function and loss-of-function experiments in the micromass culture assays revealed a positive transcriptional influence of Fhl2 in the expression of tenascin C.
Title: Four and a half domain 2 (FHL2) scaffolding protein is a marker of connective tissues of developing digits and regulates fibrogenic differentiation of limb mesodermal progenitors.
Tenascin C may regulate the recruitment of smooth muscle cells during coronary artery development
Title: Tenascin C may regulate the recruitment of smooth muscle cells during coronary artery development.
data indicate that, at least under pathological conditions, meprinbeta might attack specific functional sites in tenascin-C that are important for its oligomerization and anti-adhesive activity
Title: Specific processing of tenascin-C by the metalloprotease meprinbeta neutralizes its inhibition of cell spreading.
TNC-orchestrated molecular pathway integrates muscle repair into the load-dependent control of the striated muscle phenotype
Title: Mechano-regulated tenascin-C orchestrates muscle repair.
These results indicate that a distinct domain of tenascin-C is functionally involved in the juvenile learning process of filial imprinting and further suggest a critical role of a specific neuronal subpopulation.
Title: Regional and cellular distribution of the extracellular matrix protein tenascin-C in the chick forebrain and its role in neonatal learning.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables protein binding	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: tenascin

Names: GP 150-225; cytotactin; glioma-associated-extracellular matrix antigen; hexabrachion; myotendinous antigen; neuronectin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_205456.5 → NP_990787.3 tenascin precursor

Status: VALIDATED

Source sequence(s)

JAENSK010000308

UniProtKB/Swiss-Prot

O73584, O73585, P10039, P13132

Related

ENSGALP00010043047.1, ENSGALT00010069921.1

Conserved Domains (4) summary

smart00060
Location:683 → 765

FN3; Fibronectin type 3 domain

cd00063
Location:1318 → 1399

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd00087
Location:1586 → 1795

FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...

pfam18720
Location:471 → 497

EGF_Tenascin; Tenascin EGF domain

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

NC_052548.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Range

3320835..3419298 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_046901671.1 → XP_046757627.1 tenascin isoform X1
XM_040648966.2 → XP_040504900.1 tenascin isoform X1

UniProtKB/TrEMBL

A0A8V1AI29

Conserved Domains (4) summary

smart00060
Location:683 → 765

FN3; Fibronectin type 3 domain

cd00063
Location:1640 → 1721

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd00087
Location:1908 → 2117

FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...

pfam18720
Location:471 → 497

EGF_Tenascin; Tenascin EGF domain
XM_040648967.2 → XP_040504901.1 tenascin isoform X1

UniProtKB/TrEMBL

A0A8V1AI29

Conserved Domains (4) summary

smart00060
Location:683 → 765

FN3; Fibronectin type 3 domain

cd00063
Location:1640 → 1721

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd00087
Location:1908 → 2117

FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...

pfam18720
Location:471 → 497

EGF_Tenascin; Tenascin EGF domain
XM_046901672.1 → XP_046757628.1 tenascin isoform X1
XM_040648965.2 → XP_040504899.1 tenascin isoform X1

UniProtKB/TrEMBL

A0A8V1AI29

Conserved Domains (4) summary

smart00060
Location:683 → 765

FN3; Fibronectin type 3 domain

cd00063
Location:1640 → 1721

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd00087
Location:1908 → 2117

FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...

pfam18720
Location:471 → 497

EGF_Tenascin; Tenascin EGF domain
XM_040648963.2 → XP_040504897.1 tenascin isoform X1

UniProtKB/TrEMBL

A0A8V1AI29

Conserved Domains (4) summary

smart00060
Location:683 → 765

FN3; Fibronectin type 3 domain

cd00063
Location:1640 → 1721

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd00087
Location:1908 → 2117

FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...

pfam18720
Location:471 → 497

EGF_Tenascin; Tenascin EGF domain
XM_040648973.2 → XP_040504907.1 tenascin isoform X6

Conserved Domains (3) summary

smart00060
Location:245 → 316

FN3; Fibronectin type 3 domain

cd00063
Location:1202 → 1283

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd00087
Location:1470 → 1679

FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...
XM_040648977.2 → XP_040504911.1 tenascin isoform X10

UniProtKB/TrEMBL

Q90994

Conserved Domains (3) summary

cd00063
Location:1044 → 1125

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd00087
Location:1312 → 1521

FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...

pfam18720
Location:471 → 497

EGF_Tenascin; Tenascin EGF domain
XM_040648970.2 → XP_040504904.1 tenascin isoform X4

UniProtKB/TrEMBL

A0A8V1AI29

Conserved Domains (3) summary

cd00063
Location:1499 → 1580

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd00087
Location:1767 → 1976

FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...

pfam18720
Location:471 → 497

EGF_Tenascin; Tenascin EGF domain
XM_040648979.2 → XP_040504913.1 tenascin isoform X12

UniProtKB/Swiss-Prot

O73584, O73585, P10039, P13132

Conserved Domains (3) summary

cd00063
Location:1457 → 1538

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd00087
Location:1725 → 1934

FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...

pfam18720
Location:471 → 497

EGF_Tenascin; Tenascin EGF domain
XM_040648968.2 → XP_040504902.1 tenascin isoform X2

UniProtKB/TrEMBL

A0A8V1AI29

Conserved Domains (3) summary

cd00063
Location:1639 → 1720

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd00087
Location:1907 → 2116

FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...

pfam18720
Location:471 → 497

EGF_Tenascin; Tenascin EGF domain
XM_046901674.1 → XP_046757630.1 tenascin isoform X9

UniProtKB/TrEMBL

A0A8V1AAP4

Related

ENSGALP00010043049.1, ENSGALT00010069923.1
XM_046901673.1 → XP_046757629.1 tenascin isoform X7

UniProtKB/TrEMBL

A0A8V1AI36

Related

ENSGALP00010043048.1, ENSGALT00010069922.1
XM_040648969.2 → XP_040504903.1 tenascin isoform X3

UniProtKB/TrEMBL

A0A8V1AAN6, A0A8V1AI29

Related

ENSGALP00010043044.1, ENSGALT00010069918.1

Conserved Domains (4) summary

smart00060
Location:683 → 765

FN3; Fibronectin type 3 domain

cd00063
Location:1500 → 1581

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd00087
Location:1768 → 1977

FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...

pfam18720
Location:471 → 497

EGF_Tenascin; Tenascin EGF domain
XM_040648971.2 → XP_040504905.1 tenascin isoform X5

UniProtKB/Swiss-Prot

O73584, O73585, P10039, P13132

UniProtKB/TrEMBL

A0A8V1AM22

Related

ENSGALP00010043045.1, ENSGALT00010069919.1

Conserved Domains (4) summary

smart00060
Location:683 → 765

FN3; Fibronectin type 3 domain

cd00063
Location:1458 → 1539

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd00087
Location:1726 → 1935

FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...

pfam18720
Location:471 → 497

EGF_Tenascin; Tenascin EGF domain
XM_046901669.1 → XP_046757625.1 tenascin isoform X1
XM_046901670.1 → XP_046757626.1 tenascin isoform X1
XM_040648978.2 → XP_040504912.1 tenascin isoform X11

Conserved Domains (3) summary

smart00060
Location:683 → 765

FN3; Fibronectin type 3 domain

cd00063
Location:865 → 949

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam18720
Location:471 → 497

EGF_Tenascin; Tenascin EGF domain
XM_040648975.2 → XP_040504909.1 tenascin isoform X8

UniProtKB/TrEMBL

Q90995

Conserved Domains (3) summary

smart00060
Location:683 → 765

FN3; Fibronectin type 3 domain

cd00063
Location:865 → 949

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam18720
Location:471 → 497

EGF_Tenascin; Tenascin EGF domain