CD3D CD3d molecule [Gallus gallus (chicken)] - Gene

Summary

Symbol: CD3Dprovided by CGNC
Full Name: CD3d moleculeprovided by CGNC
Primary source: CGNC:49849
See related: Ensembl:ENSGALG00010023743
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as: CD3
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Genomic context

Location:: chromosome: 24

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	24	NC_052555.1 (5513856..5516395, complement)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	24	NC_052596.1 (5474142..5476674, complement)

Chromosome 24 - NC_052555.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

NMR structure of the chicken CD3epsilondelta/gamma heterodimer revealed a unique dimer interface that results in a heterodimer with considerable deviation from the human and murine CD3epsilondelta and CD3epsilongamma; chicken CD3epsilondelta/gamma heterodimer also contains a unique molecular surface, with the majority of surface-exposed, nonconserved residues being clustered to a single face of the heterodimer.
Title: Structure of the chicken CD3εδ/γ heterodimer and its assembly with the αβT cell receptor.
A second TCR delta locus in chickens uses antibody-like V domains.
Title: A second TCRδ locus in Galliformes uses antibody-like V domains: insight into the evolution of TCRδ and TCRμ genes in tetrapods.
The alleles of CD8 alpha and CD3d cDNA from Chinese native and introduced western breeds of chicken were analyzed at the sequence level.
Title: New alleles of chicken CD8 alpha and CD3d found in Chinese native and western breeds.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables transmembrane signaling receptor activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in cell surface receptor signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive thymic T cell selection	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
part_of alpha-beta T cell receptor complex	IEA Inferred from Electronic Annotation more info	PubMed
located_in external side of plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: T-cell surface glycoprotein CD3 delta chain

Names: CD3 glycoprotein; CD3 type I transmembrane glycoprotein; CD3D antigen delta; CD3D antigen, delta polypeptide (TiT3 complex); CD3d molecule, delta (CD3-TCR complex); T-cell surface protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_205512.2 → NP_990843.2 T-cell surface glycoprotein CD3 delta chain precursor

Status: VALIDATED

Source sequence(s)

JAENSK010000341

UniProtKB/TrEMBL

Q6PVZ9

Related

ENSGALP00010035130.1, ENSGALT00010057903.1

Conserved Domains (1) summary

smart00077
Location:152 → 171

ITAM; Immunoreceptor tyrosine-based activation motif

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

NC_052555.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Range

5513856..5516395 complement

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GenBank, FASTA, Sequence Viewer (Graphics)