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GOT1 glutamic-oxaloacetic transaminase 1 [ Sus scrofa (pig) ]

Gene ID: 396967, updated on 5-Mar-2024

Summary

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Official Symbol
GOT1provided by VGNC
Official Full Name
glutamic-oxaloacetic transaminase 1provided by VGNC
Primary source
VGNC:VGNC:88561
See related
Ensembl:ENSSSCG00000010537
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Sus scrofa
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Also known as
cCAT; CASPAT
Expression
Broad expression in heart (RPKM 210.3), psoas major muscle (RPKM 154.0) and 7 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 14
Exon count:
9
Annotation release Status Assembly Chr Location
106 current Sscrofa11.1 (GCF_000003025.6) 14 NC_010456.5 (110608422..110635825, complement)
105 previous assembly Sscrofa10.2 (GCF_000003025.5) 14 NC_010456.4 (120054006..120080894, complement)

Chromosome 14 - NC_010456.5Genomic Context describing neighboring genes Neighboring gene heparanase 2 (inactive) Neighboring gene uncharacterized LOC106508431 Neighboring gene cyclin and CBS domain divalent metal cation transport mediator 1 Neighboring gene uncharacterized LOC106506106 Neighboring gene NK2 homeobox 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Transcriptome data used for gene annotation
  • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
  • BioProject: PRJNA311523
  • Publication: PMID 27646534
  • Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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Related articles in PubMed

  1. The complete amino acid sequence of cytoplasmic aspartate aminotransferase from pig heart. Ovchinnikov YA, et al. FEBS Lett, 1973 Jan 1. PMID 11946901
  2. Refinement and comparisons of the crystal structures of pig cytosolic aspartate aminotransferase and its complex with 2-methylaspartate. Rhee S, et al. J Biol Chem, 1997 Jul 11. PMID 9211866
  3. Primary structure of pyridoxal phosphate binding site in the mitochondrial and extramitochondrial aspartate aminotransferases from pig heart muscle. Chymotryptic peptides. Morino Y, et al. Biochemistry, 1969 Aug. PMID 5809231
  4. The position of an essential tyrosine residue in the polypeptide chain of aspartate transaminase. Polyanovsky OL, et al. FEBS Lett, 1972 Jun 15. PMID 4634443
  5. cDNA cloning and expression of pig cytosolic aspartate aminotransferase in Escherichia coli: amino-terminal heterogeneity of expressed products and lack of its correlation with enzyme function. Nagashima F, et al. Biochemistry, 1989 Feb 7. PMID 2653435

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. GOT1 is a suitable candidate gene for the serum aspartate aminotransferase activity QTL on SSC14.
    Title: SNPs in the porcine GOT1 gene improve a QTL for serum aspartate aminotransferase activity on SSC14.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables L-aspartate:2-oxoglutarate aminotransferase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables pyridoxal phosphate binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in aspartate biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
aspartate aminotransferase, cytoplasmic
Names
cysteine aminotransferase, cytoplasmic
cysteine transaminase, cytoplasmic
glutamate oxaloacetate transaminase 1
glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1)
transaminase A
NP_999092.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_213927.1 → NP_999092.1  aspartate aminotransferase, cytoplasmic

    See identical proteins and their annotated locations for NP_999092.1

    Status: PROVISIONAL

    Source sequence(s)
    M24088
    UniProtKB/Swiss-Prot
    P00503
    UniProtKB/TrEMBL
    A0A1B2TT55, A0A480YWX1
    Related
    ENSSSCP00000011226.2, ENSSSCT00000011527.4
    Conserved Domains (2) summary
    PTZ00376
    Location:5 → 412
    PTZ00376; aspartate aminotransferase; Provisional
    pfam00155
    Location:31 → 405
    Aminotran_1_2; Aminotransferase class I and II

RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Sscrofa11.1 Primary Assembly

Genomic

  1. NC_010456.5 Reference Sscrofa11.1 Primary Assembly

    Range
    110608422..110635825 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P00503.3 GenPept UniProtKB/Swiss-Prot:P00503

Gene LinkOut

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