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CLU clusterin [ Sus scrofa (pig) ]

Gene ID: 397025, updated on 5-Mar-2024

Summary

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Official Symbol
CLUprovided by VGNC
Official Full Name
clusterinprovided by VGNC
Primary source
VGNC:VGNC:86790
See related
Ensembl:ENSSSCG00000009668
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Sus scrofa
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Summary
This gene encodes a protein that is similar to the human clusterin protein, a secreted chaperone that can also be found in the cell cytosol under certain stress conditions. The human protein has been suggested to be involved in several basic biological events such as cell death, tumor progression, and neurodegenerative disorders. [provided by RefSeq, May 2011]
Expression
Broad expression in liver (RPKM 1080.2), mixtures (RPKM 535.5) and 6 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 14
Exon count:
11
Annotation release Status Assembly Chr Location
106 current Sscrofa11.1 (GCF_000003025.6) 14 NC_010456.5 (11336585..11352569, complement)
105 previous assembly Sscrofa10.2 (GCF_000003025.5) 14 NC_010456.4 (12516644..12527851, complement)

Chromosome 14 - NC_010456.5Genomic Context describing neighboring genes Neighboring gene epoxide hydrolase 2 Neighboring gene gulonolactone (L-) oxidase Neighboring gene uncharacterized LOC106508065 Neighboring gene scavenger receptor class A member 3 Neighboring gene coiled-coil domain containing 25

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Transcriptome data used for gene annotation
  • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
  • BioProject: PRJNA311523
  • Publication: PMID 27646534
  • Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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Related articles in PubMed

  1. Clusterin expression in porcine endocrine cells during islet development. Schweiger M, et al. Horm Metab Res, 2007 Dec. PMID 17960512
  2. The glycoproteins that occur in the colloids of senescent porcine pituitary glands are clusterin and glycosylated albumin fragments. Ogawa S, et al. Biochem Biophys Res Commun, 1997 May 29. PMID 9175781
  3. Expression of porcine complement cytolysis inhibitor mRNA in cultured aortic smooth muscle cells. Changes during differentiation in vitro. Diemer V, et al. J Biol Chem, 1992 Mar 15. PMID 1544909
  4. Interactive host cells related to Mycoplasma suis α-enolase by yeast two-hybrid analysis. Liu M, et al. Res Vet Sci, 2014 Oct. PMID 25085536
  5. Resistance of neonatal porcine Sertoli cells to human xenoantibody and complement-mediated lysis is associated with low expression of alpha-Gal and high production of clusterin and CD59. Yin Z, et al. Xenotransplantation, 2010 May-Jun. PMID 20636542

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data demonstrate that the resistance of neonatal porcine Sertoli cells to human xenoantibody and complement-mediated lysis is associated with low expression of xenoantigen alpha-Gal and high production of the complement inhibitors clusterin and CD59.
    Title: Resistance of neonatal porcine Sertoli cells to human xenoantibody and complement-mediated lysis is associated with low expression of alpha-Gal and high production of clusterin and CD59.
  2. Porcine spermatozoa may delivery CLU, PRM1 and PRM2 mRNAs to the oocyte, which may contribute to zygotic and early embryonic development.
    Title: Analysis of selected transcript levels in porcine spermatozoa, oocytes, zygotes and two-cell stage embryos.
  3. These results show that clusterin expression in porcine species is found in an own, as yet unidentified cell type during postnatal developmental stages.
    Title: Clusterin expression in porcine endocrine cells during islet development.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

General protein information

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Preferred Names
clusterin
Names
CLI
CP40
complement cytolysis inhibitor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_213971.1 → NP_999136.1  clusterin precursor

    See identical proteins and their annotated locations for NP_999136.1

    Status: PROVISIONAL

    Source sequence(s)
    M84639
    UniProtKB/Swiss-Prot
    Q29549
    UniProtKB/TrEMBL
    A0A5S8KLN1, A0A8D1MCD3
    Conserved Domains (1) summary
    pfam01093
    Location:30 → 441
    Clusterin; Clusterin

RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Sscrofa11.1 Primary Assembly

Genomic

  1. NC_010456.5 Reference Sscrofa11.1 Primary Assembly

    Range
    11336585..11352569 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021072081.1 → XP_020927740.1  clusterin isoform X2

    UniProtKB/Swiss-Prot
    Q29549
    UniProtKB/TrEMBL
    A0A5S8KLN1, A0A8D1MCD3
    Conserved Domains (1) summary
    pfam01093
    Location:30 → 441
    Clusterin; Clusterin

  2. XM_021072080.1 → XP_020927739.1  clusterin isoform X1

    UniProtKB/TrEMBL
    A0A8D0IAU9, A0A8D1FY67
    Conserved Domains (1) summary
    pfam01093
    Location:58 → 467
    Clusterin

  3. XM_021072082.1 → XP_020927741.1  clusterin isoform X2

    UniProtKB/Swiss-Prot
    Q29549
    UniProtKB/TrEMBL
    A0A5S8KLN1, A0A8D1MCD3
    Conserved Domains (1) summary
    pfam01093
    Location:30 → 441
    Clusterin; Clusterin

  4. XM_021072086.1 → XP_020927745.1  clusterin isoform X2

    UniProtKB/Swiss-Prot
    Q29549
    UniProtKB/TrEMBL
    A0A5S8KLN1, A0A8D1MCD3
    Conserved Domains (1) summary
    pfam01093
    Location:30 → 441
    Clusterin; Clusterin

  5. XM_021072088.1 → XP_020927747.1  clusterin isoform X2

    UniProtKB/Swiss-Prot
    Q29549
    UniProtKB/TrEMBL
    A0A5S8KLN1, A0A8D1MCD3
    Conserved Domains (1) summary
    pfam01093
    Location:30 → 441
    Clusterin; Clusterin

  6. XM_021072087.1 → XP_020927746.1  clusterin isoform X2

    UniProtKB/Swiss-Prot
    Q29549
    UniProtKB/TrEMBL
    A0A5S8KLN1, A0A8D1MCD3
    Conserved Domains (1) summary
    pfam01093
    Location:30 → 441
    Clusterin; Clusterin

  7. XM_021072085.1 → XP_020927744.1  clusterin isoform X2

    UniProtKB/Swiss-Prot
    Q29549
    UniProtKB/TrEMBL
    A0A5S8KLN1, A0A8D1MCD3
    Conserved Domains (1) summary
    pfam01093
    Location:30 → 441
    Clusterin; Clusterin

  8. XM_021072084.1 → XP_020927743.1  clusterin isoform X2

    UniProtKB/Swiss-Prot
    Q29549
    UniProtKB/TrEMBL
    A0A5S8KLN1, A0A8D1MCD3
    Related
    ENSSSCP00000010325.4, ENSSSCT00000010601.4
    Conserved Domains (1) summary
    pfam01093
    Location:30 → 441
    Clusterin; Clusterin
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q29549.1 GenPept UniProtKB/Swiss-Prot:Q29549

Gene LinkOut

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