FBP1 fructose-bisphosphatase 1 [Sus scrofa (pig)] - Gene

Summary

Official Symbol: FBP1provided by VGNC
Official Full Name: fructose-bisphosphatase 1provided by VGNC
Primary source: VGNC:VGNC:96297
See related: Ensembl:ENSSSCG00000031174
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Sus scrofa
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Also known as: FBP
Expression: Biased expression in kidney (RPKM 818.9), liver (RPKM 579.0) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 10

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
106	current	Sscrofa11.1 (GCF_000003025.6)	10	NC_010452.4 (27588609..27622225)
105	previous assembly	Sscrofa10.2 (GCF_000003025.5)	10	NC_010452.3 (31712560..31829432)

Chromosome 10 - NC_010452.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Transcriptome data used for gene annotation
Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
BioProject: PRJNA311523
Publication: PMID 27646534
Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Fructose-1,6-bisphosphatase mutations in the AMP-binding site (K112A and Y113A) demonstrated an eight to nine-fold decrease in AMP inhibition.
Title: Characterization of recombinant fructose-1,6-bisphosphatase gene mutations: evidence of inhibition/activation of FBPase protein by gene mutation.
Directed mutations, kinetics, and structure determinations link the central cavity of FBP to AMP/fructose 2,6-bisphosphate synergism.
Title: Central cavity of fructose-1,6-bisphosphatase and the evolution of AMP/fructose 2,6-bisphosphate synergism in eukaryotic organisms.
The AMP/Mg(2+) and AMP/Zn(2+) complexes of Asp(10) FBPase are in intermediate quaternary conformations.
Title: Mechanism of displacement of a catalytically essential loop from the active site of mammalian fructose-1,6-bisphosphatase.
each subunit in the wild-type tetramer can independently achieve maximum velocity when activated by Mg(2+); findings are fully consistent with a mechanism of cooperativity that arises from within a single subunit of fructose-1,6-bisphosphatase.
Title: Origin of cooperativity in the activation of fructose-1,6-bisphosphatase by Mg2+.
The primary structures of muscle FBPases , showed on their molecular surface a number of domains specific for proteins transported into the nucleus.
Title: Nuclear localization of fructose 1,6-bisphosphatase in smooth muscle cells.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables fructose 1,6-bisphosphate 1-phosphatase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in fructose 1,6-bisphosphate metabolic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in fructose 6-phosphate metabolic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in fructose metabolic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in gluconeogenesis	IEA Inferred from Electronic Annotation more info	PubMed
involved_in sucrose biosynthetic process	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info	PubMed
located_in cytosol	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: fructose-1,6-bisphosphatase 1

Names: D-fructose-1,6-bisphosphate 1-phosphohydrolase 1; FBPase 1; fructose 1,6-bisphosphatase; liver FBPase

NP_999144.1

EC 3.1.3.11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_213979.1 → NP_999144.1 fructose-1,6-bisphosphatase 1

See identical proteins and their annotated locations for NP_999144.1

Status: PROVISIONAL

Source sequence(s)

M86347

UniProtKB/Swiss-Prot

P00636

UniProtKB/TrEMBL

A0A8D1EC60

Related

ENSSSCP00000049752.1, ENSSSCT00000065852.3

Conserved Domains (1) summary

cd00354
Location:18 → 332

FBPase; Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1, ...