zic1.S Zic family member 1 S homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: zic1.S
Official Full Name: Zic family member 1 S homeolog
Primary source: Xenbase:XB-GENE-864815
Locus tag: XELAEV_18029829mg
See related: EnsemblRapid:ENSXLAG00005002859
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: opl; zic1; zic1.L
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Genomic context

Location:: chromosome: 5S

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	5S	NC_054380.1 (109229133..109233772)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	5S	NC_030733.1 (102483503..102488142)

Chromosome 5S - NC_054380.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Anterior patterning genes induced by Zic1 are sensitive to retinoic acid and its metabolite, 4-oxo-RA.
Title: Anterior patterning genes induced by Zic1 are sensitive to retinoic acid and its metabolite, 4-oxo-RA.
PR domaincontaining protein 12 (prdm12) is a downstream target of the transcription factor zic1 during cellular differentiation in the central nervous system: PR domain containing protein is the right form.
Title: PR domaincontaining protein 12 (prdm12) is a downstream target of the transcription factor zic1 during cellular differentiation in the central nervous system: PR domain containing protein is the right form.
Zyxin has a scaffolding role in Gli1 and Zic1 interactions and in the regulation of Shh signaling cascade
Title: The cytoskeletal protein Zyxin interacts with the zinc-finger transcription factor Zic1 and plays the role of a scaffold for Gli1 and Zic1 interactions during early development of Xenopus laevis.
snai2 and sox10 expression was severely impaired upon manipulation of Znf703 expression levels in the embryo suggesting that Znf703 participates in neural crest formation downstream of Pax3 and Zic1 in Xenopus
Title: Znf703, a novel target of Pax3 and Zic1, regulates hindbrain and neural crest development in Xenopus.
Zic1, expressed at the anterior neural plate, is necessary and sufficient to promote placode fate.
Title: Zic1 controls placode progenitor formation non-cell autonomously by regulating retinoic acid production and transport.
Pax3 and Zic1 trigger the early neural crest gene regulatory network by the direct activation of multiple key neural crest specifiers.
Title: Pax3 and Zic1 trigger the early neural crest gene regulatory network by the direct activation of multiple key neural crest specifiers.
Pax3 and Zic1 drive induction and differentiation of multipotent, migratory, and functional neural crest in Xenopus embryos.
Title: Pax3 and Zic1 drive induction and differentiation of multipotent, migratory, and functional neural crest in Xenopus embryos.
XMeis3 protein knock down also causes a loss of primary neuron and neural crest cell lineages, without altering expression of Zic, Sox or Pax3 genes.
Title: Xenopus Meis3 protein lies at a nexus downstream to Zic1 and Pax3 proteins, regulating multiple cell-fates during early nervous system development.
aqp-3b was upregulated by Zic1
Title: A microarray screen for direct targets of Zic1 identifies an aquaporin gene, aqp-3b, expressed in the neural folds.
Data show that Pax3 and Zic1 are necessary and sufficient to promote hatching gland and preplacodal fates, respectively, and that their combined activity is essential to specify the neural crest.
Title: The activity of Pax3 and Zic1 regulates three distinct cell fates at the neural plate border.

Submit: New GeneRIF Correction See all GeneRIFs (14)

General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within dorsal/ventral neural tube patterning	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within nervous system development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within neural crest cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neural crest cell fate commitment	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within neural crest cell fate commitment	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neural crest formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neural plate development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neurogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of Wnt signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of protein import into nucleus	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: zinc finger protein ZIC 1

Names: XZic1; ZIC-r1; ZIC-related protein 1; Zic family member 1 (odd-paired homolog); Zic family member 1 L homeolog; Zic-related-1; xlZic1; xopl; zinc finger protein of the cerebellum 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001090330.1 → NP_001083799.1 zinc finger protein ZIC 1

See identical proteins and their annotated locations for NP_001083799.1

Status: PROVISIONAL

Source sequence(s)

AF028805

UniProtKB/Swiss-Prot

O57461, O73689

UniProtKB/TrEMBL

A0A974HI46

Related

ENSXLAP00005008542.1, ENSXLAT00005008668.1

Conserved Domains (3) summary

sd00017
Location:272 → 292

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:358 → 380

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:314 → 341

zf-H2C2_2; Zinc-finger double domain