tbxt.S T-box transcription factor T S homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: tbxt.S
Official Full Name: T-box transcription factor T S homeolog
Primary source: Xenbase:XB-GENE-865212
Locus tag: XELAEV_18029080mg
See related: EnsemblRapid:ENSXLAG00005007642
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: bu; ta; bra; ntl; t-a; t-b; t.L; t.S; tbxt; xbra; X-bra; brachyury; Xbrachyury
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Genomic context

Location:: chromosome: 5S

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	5S	NC_054380.1 (46833750..46841009, complement)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	5S	NC_030733.1 (46673037..46680005, complement)

Chromosome 5S - NC_054380.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Xbra and Smad-1 interaction cooperatively enhanced the binding of an interacting partner within the ventx1.1 promoter and maximum cooperation was achieved in presence of intact DNA binding sites for both Smad-1 and Xbra.
Title: Xbra and Smad-1 cooperate to activate the transcription of neural repressor ventx1.1 in Xenopus embryos.
Disrupting the pattern of division by placing embryos in a temperature gradient resulted in highly asynchronous entry to the midblastula transition and misexpression of the mesodermal protein Xbra.
Title: Desynchronizing Embryonic Cell Division Waves Reveals the Robustness of Xenopus laevis Development.
DN-Xbra inhibits PV.1 expression and that the suppression of PV.1 reduces overall BMP signaling by inducing chordin and goosecoid expression.
Title: PV.1 induced by FGF-Xbra functions as a repressor of neurogenesis in Xenopus embryos.
EphA4-dependent Brachyury expression is required for dorsal mesoderm involution in the Xenopus gastrula.
Title: EphA4-dependent Brachyury expression is required for dorsal mesoderm involution in the Xenopus gastrula.
This is the first report to demonstrate that Brachyury might affect the cytoskeletal structure through regulating the expression of an intermediate filament protein, vimentin.
Title: In silico and in vivo identification of the intermediate filament vimentin that is downregulated downstream of Brachyury during Xenopus embryogenesis.
Data suggest a dual regulation in which XESR5 produces a competent area for mesoderm formation by suppressing the gene expression of XESR1, while XESR1 sharpens the boundary of Xbra expression.
Title: Antagonistic role of XESR1 and XESR5 in mesoderm formation in Xenopus laevis.
AP-2rep is involved in the morphogenesis of the mesoderm at the gastrula stage, via the brachyury and/or Wnt pathways.
Title: Involvement of AP-2rep in morphogenesis of the axial mesoderm in Xenopus embryo.
Embryo elongation can occur through the synergistic effect(s) of the organizer molecule chordin, and the 'verall posteriorizing molecule Xbra.
Title: VegT, eFGF and Xbra cause overall posteriorization while Xwnt8 causes eye-level restricted posteriorization in synergy with chordin in early Xenopus development.
controls the early homeobox gene expression domain in the animal-vegetal direction
Title: The initiation of Hox gene expression in Xenopus laevis is controlled by Brachyury and BMP-4.
findings reveal that the N-terminal domain that restricts the inducing activity of Xbra interacts with Smad1
Title: Functional specificity of the Xenopus T-domain protein Brachyury is conferred by its ability to interact with Smad1.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell fate specification	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to fibroblast growth factor stimulus	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within determination of left/right symmetry	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryonic axis specification	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within heart morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mesoderm formation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within somitogenesis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: T-box transcription factor T

Names: T brachyury transcription factor L homeolog; T brachyury transcription factor S homeolog; T, brachyury homolog a; brachyury (T); protein T

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001090578.1 → NP_001084047.1 T-box transcription factor T

See identical proteins and their annotated locations for NP_001084047.1

Status: PROVISIONAL

Source sequence(s)

BC072031

UniProtKB/Swiss-Prot

P24781, Q6IP86

UniProtKB/TrEMBL

A0A974CSE4

Related

ENSXLAP00005021746.1, ENSXLAT00005022438.1

Conserved Domains (2) summary

cd00182
Location:40 → 221

TBOX; T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA ...

pfam10267
Location:315 → 412

Tmemb_cc2; Predicted transmembrane and coiled-coil 2 protein

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

NC_054380.1 Reference Xenopus_laevis_v10.1 Primary Assembly

Range

46833750..46841009 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_041563962.1 → XP_041419896.1 T-box transcription factor T isoform X1

UniProtKB/TrEMBL

A0A8J1KRG6

Conserved Domains (1) summary

smart00425
Location:40 → 222

TBOX; Domain first found in the mice T locus (Brachyury) protein