cpeb1.L cytoplasmic polyadenylation element binding protein 1 L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: cpeb1.L
Official Full Name: cytoplasmic polyadenylation element binding protein 1 L homeolog
Primary source: Xenbase:XB-GENE-946172
Locus tag: XELAEV_18018089mg
See related: EnsemblRapid:ENSXLAG00005036365
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: CPEB; cpeb1; Cpeb-1; cpeb1-a; cpeb1-b
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Genomic context

Location:: chromosome: 3L

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	3L	NC_054375.1 (100129026..100171794, complement)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	3L	NC_030728.1 (84822773..84865428, complement)

Chromosome 3L - NC_054375.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

miR-15/16 and CPEB co-regulate cyclin E1 mRNA.
Title: CPEB and miR-15/16 Co-Regulate Translation of Cyclin E1 mRNA during Xenopus Oocyte Maturation.
Pin1 is an essential factor regulating CPEB degradation
Title: An unusual two-step control of CPEB destruction by Pin1.
Data show that CPEB1 mRNA transcripts are present at low levels in RGCs but, surprisingly, CPEB1 protein was not detected in eye or brain tissue, and CPEB1 loss-of-function does not affect chemotropic responses or pathfinding in vivo.
Title: Cytoplasmic polyadenylation and cytoplasmic polyadenylation element-dependent mRNA regulation are involved in Xenopus retinal axon development.
affects experience-dependent neuronal development and circuit formation in the visual system of Xenopus laevis
Title: The RNA binding protein CPEB regulates dendrite morphogenesis and neuronal circuit assembly in vivo.
CPEB, partnered with several highly conserved RNA-binding partners, inhibits protein synthesis in oocytes using a novel pairing of 4E-T and eIF4E1b
Title: CPEB interacts with an ovary-specific eIF4E and 4E-T in early Xenopus oocytes.
Xenopus Gef (XGef), a Rho-family guanine-exchange factor, influences the activating phosphorylation of CPEB.
Title: MAPK interacts with XGef and is required for CPEB activation during meiosis in Xenopus oocytes.
These results demonstrate that a reversible Pum2 interaction controls RINGO/Spy mRNA translation and, as a result, CPEB-mediated cytoplasmic polyadenylation
Title: Regulated Pumilio-2 binding controls RINGO/Spy mRNA translation and CPEB activation.
CPEB is not required for regulation of early class maternal mRNA translational activation in Xenopus oocytes
Title: Cytoplasmic polyadenylation element (CPE)- and CPE-binding protein (CPEB)-independent mechanisms regulate early class maternal mRNA translational activation in Xenopus oocytes.
XGef is involved in early CPEB activation with GTPase signaling
Title: XGef mediates early CPEB phosphorylation during Xenopus oocyte meiotic maturation.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables mRNA 3'-UTR AU-rich region binding	ISS Inferred from Sequence or Structural Similarity more info
enables mRNA 3'-UTR binding	IEA Inferred from Electronic Annotation more info
enables mRNA regulatory element binding translation repressor activity	IEA Inferred from Electronic Annotation more info
enables mRNA regulatory element binding translation repressor activity	ISS Inferred from Sequence or Structural Similarity more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ribosome binding	IEA Inferred from Electronic Annotation more info
enables translation factor activity, RNA binding	IEA Inferred from Electronic Annotation more info
enables translation regulator activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cellular response to amino acid stimulus	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within cellular response to hypoxia	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within cellular response to insulin stimulus	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within mRNA processing	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within midbrain development	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of cytoplasmic translation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of cytoplasmic translation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within neural precursor cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of translation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in centrosome	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
part_of messenger ribonucleoprotein complex	IEA Inferred from Electronic Annotation more info
located_in neuron projection	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
part_of protein-containing complex	IPI Inferred from Physical Interaction more info	PubMed
part_of ribonucleoprotein complex	IEA Inferred from Electronic Annotation more info
part_of ribonucleoprotein complex	IPI Inferred from Physical Interaction more info	PubMed
located_in spindle pole	IEA Inferred from Electronic Annotation more info
located_in synapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: cytoplasmic polyadenylation element-binding protein 1-A

Names: 58 kDa CPE-binding protein; CPE-BP1-A; CPE-binding protein 1-A; CPEB-1-A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001090603.1 → NP_001084072.1 cytoplasmic polyadenylation element-binding protein 1-A

See identical proteins and their annotated locations for NP_001084072.1

Status: PROVISIONAL

Source sequence(s)

U14169

UniProtKB/Swiss-Prot

B7ZRW6, B7ZRZ4, Q91572

Related

ENSXLAP00005108790.1, ENSXLAT00005110954.1

Conserved Domains (4) summary

cd12723
Location:311 → 418

RRM1_CPEB1; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins

cd12725
Location:429 → 514

RRM2_CPEB1; RNA recognition motif 2 in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins

pfam16366
Location:506 → 561

CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain

pfam16368
Location:1 → 309

CEBP1_N; Cytoplasmic polyadenylation element-binding protein 1 N-terminus

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

NC_054375.1 Reference Xenopus_laevis_v10.1 Primary Assembly

Range

100129026..100171794 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_041585019.1 → XP_041440953.1 cytoplasmic polyadenylation element-binding protein 1-A isoform X3

UniProtKB/TrEMBL

A0A8J1MHF3, A0A974DC99

Conserved Domains (2) summary

smart00360
Location:314 → 376

RRM; RNA recognition motif

cd19757
Location:511 → 551

Bbox1; B-box-type 1 zinc finger (Bbox1)
XM_041585018.1 → XP_041440952.1 cytoplasmic polyadenylation element-binding protein 1-A isoform X2

UniProtKB/TrEMBL

A0A8J1MGW1, A0A974DC99

Conserved Domains (2) summary

smart00360
Location:329 → 391

RRM; RNA recognition motif

cd19757
Location:526 → 566

Bbox1; B-box-type 1 zinc finger (Bbox1)
XM_041585017.1 → XP_041440951.1 cytoplasmic polyadenylation element-binding protein 1-A isoform X1

UniProtKB/TrEMBL

A0A8J1MHU0, A0A974DC99

Related

ENSXLAP00005108787.1, ENSXLAT00005110951.1

Conserved Domains (2) summary

smart00360
Location:329 → 396

RRM; RNA recognition motif

cd19757
Location:531 → 571

Bbox1; B-box-type 1 zinc finger (Bbox1)
XM_041585020.1 → XP_041440954.1 cytoplasmic polyadenylation element-binding protein 1-A isoform X4

UniProtKB/TrEMBL

A0A8J1MIS3, A0A974DC99

Conserved Domains (2) summary

smart00360
Location:275 → 342

RRM; RNA recognition motif

cd19757
Location:477 → 517

Bbox1; B-box-type 1 zinc finger (Bbox1)
XM_041585021.1 → XP_041440955.1 cytoplasmic polyadenylation element-binding protein 1-A isoform X4

UniProtKB/TrEMBL

A0A8J1MIS3, A0A974DC99

Related

ENSXLAP00005108785.1, ENSXLAT00005110949.1

Conserved Domains (2) summary

smart00360
Location:275 → 342

RRM; RNA recognition motif

cd19757
Location:477 → 517

Bbox1; B-box-type 1 zinc finger (Bbox1)