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CG7408 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 39991, updated on 11-Apr-2024

Summary

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Official Symbol
CG7408provided by FlyBase
Primary source
FLYBASE:FBgn0036765
Locus tag
Dmel_CG7408
See related
AllianceGenome:FB:FBgn0036765
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG7408
Summary
Predicted to enable sulfuric ester hydrolase activity. Involved in defense response to bacterium. Is expressed in adult head. Human ortholog(s) of this gene implicated in mucopolysaccharidosis VI. Orthologous to human ARSB (arylsulfatase B); ARSI (arylsulfatase family member I); and ARSJ (arylsulfatase family member J). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See CG7408 in Genome Data Viewer
Location:
75A7-75A8; 3-45 cM
Exon count:
7
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (17879096..17883653)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (17872196..17876753)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene pseudo Neighboring gene uncharacterized protein Neighboring gene pseudo Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. How Many Parameters Does It Take to Describe Disease Tolerance? Louie A, et al. PLoS Biol, 2016 Apr. PMID 27088212, Free PMC Article
  2. The Exon Junction Complex and intron removal prevent re-splicing of mRNA. Joseph B, et al. PLoS Genet, 2021 May. PMID 34033644, Free PMC Article
  3. Discovery and functional prioritization of Parkinson's disease candidate genes from large-scale whole exome sequencing. Jansen IE, et al. Genome Biol, 2017 Jan 30. PMID 28137300, Free PMC Article
  4. Identification of Drosophila mutants altering defense of and endurance to Listeria monocytogenes infection. Ayres JS, et al. Genetics, 2008 Mar. PMID 18245331, Free PMC Article
  5. Mating-responsive genes in reproductive tissues of female Drosophila melanogaster. Mack PD, et al. Proc Natl Acad Sci U S A, 2006 Jul 5. PMID 16798875, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in defense response to bacterium IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
uncharacterized protein
Names
CG7408-PB
CG7408-PC
CG7408-PD
NP_001163462.1
NP_001163463.1
NP_649020.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    17879096..17883653
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_140763.2 → NP_649020.1  uncharacterized protein Dmel_CG7408, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_649020.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VVM1
    Related
    FBpp0074908
    Conserved Domains (2) summary
    COG3119
    Location:31 → 425
    AslA; Arylsulfatase A or related enzyme [Inorganic ion transport and metabolism]
    cd16029
    Location:35 → 423
    4-S; N-acetylgalactosamine 4-sulfatase, also called arylsulftase B

  2. NM_001169991.2 → NP_001163462.1  uncharacterized protein Dmel_CG7408, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163462.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VVM1
    Conserved Domains (2) summary
    COG3119
    Location:31 → 425
    AslA; Arylsulfatase A or related enzyme [Inorganic ion transport and metabolism]
    cd16029
    Location:35 → 423
    4-S; N-acetylgalactosamine 4-sulfatase, also called arylsulftase B

  3. NM_001169992.2 → NP_001163463.1  uncharacterized protein Dmel_CG7408, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163463.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VVM1
    Conserved Domains (2) summary
    COG3119
    Location:31 → 425
    AslA; Arylsulfatase A or related enzyme [Inorganic ion transport and metabolism]
    cd16029
    Location:35 → 423
    4-S; N-acetylgalactosamine 4-sulfatase, also called arylsulftase B
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8MS40 Q8MS40
Q9VVM1 Q9VVM1

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