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Ltn1 Listerin E3 ubiquitin protein ligase 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40127, updated on 10-May-2024

Summary

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Official Symbol
Ltn1provided by FlyBase
Official Full Name
Listerin E3 ubiquitin protein ligase 1provided by FlyBase
Primary source
FLYBASE:FBgn0262517
Locus tag
Dmel_CG32210
See related
AllianceGenome:FB:FBgn0262517
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG32210; CG9268; CG9274; Dmel\CG32210; l(3)76BDr
Summary
Predicted to enable ribosomal large subunit binding activity; ubiquitin protein ligase activity; and zinc ion binding activity. Involved in ribosome-associated ubiquitin-dependent protein catabolic process. Predicted to be part of RQC complex. Predicted to be active in cytosol. Is expressed in adult head. Orthologous to human LTN1 (listerin E3 ubiquitin protein ligase 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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See Ltn1 in Genome Data Viewer
Location:
76B6-76B7; 3-45 cM
Exon count:
14
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (19544345..19552290, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (19537445..19545390, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Cuticular protein 76Bd Neighboring gene uncharacterized protein Neighboring gene Dctn1-related Neighboring gene antisense RNA:CR43885 Neighboring gene uncharacterized protein Neighboring gene Reduction in Cnn dots 7 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44677

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A functional involvement of ABCE1, eukaryotic ribosome recycling factor, in nonstop mRNA decay in Drosophila melanogaster cells. Kashima I, et al. Biochimie, 2014 Nov. PMID 25128630
  2. Inefficient quality control of ribosome stalling during APP synthesis generates CAT-tailed species that precipitate hallmarks of Alzheimer's disease. Rimal S, et al. Acta Neuropathol Commun, 2021 Oct 18. PMID 34663454, Free PMC Article
  3. Mechanisms Linking Mitochondrial Dysfunction and Proteostasis Failure. Lu B, et al. Trends Cell Biol, 2020 Apr. PMID 32200806, Free PMC Article
  4. Drosophila pipe protein activity in the ovary and the embryonic salivary gland does not require heparan sulfate glycosaminoglycans. Zhu X, et al. Development, 2005 Sep. PMID 16049108
  5. Quality-control mechanisms targeting translationally stalled and C-terminally extended poly(GR) associated with ALS/FTD. Li S, et al. Proc Natl Acad Sci U S A, 2020 Oct 6. PMID 32958650, Free PMC Article

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ribosomal large subunit binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding ISM
Inferred from Sequence Model
more info
 PubMed 
Process Evidence Code Pubs
involved_in rescue of stalled ribosome IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ribosome-associated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ribosome-associated ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in ribosome-associated ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of RQC complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of RQC complex IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
listerin E3 ubiquitin protein ligase 1
Names
CG32210-PA
Ltn1-PA
l(3)76BDr
listerin

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    19544345..19552290 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_168802.2 → NP_730427.1  listerin E3 ubiquitin protein ligase 1 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_730427.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8T3L4, Q9VW09
    Related
    FBpp0074742
    Conserved Domains (1) summary
    cl17238
    Location:1724 → 1744
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VW09.2 Q9VW09

Gene LinkOut

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