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tey teyrha-meyrha [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40146, updated on 10-May-2024

Summary

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Official Symbol
teyprovided by FlyBase
Official Full Name
teyrha-meyrhaprovided by FlyBase
Primary source
FLYBASE:FBgn0036899
Locus tag
Dmel_CG8780
See related
AllianceGenome:FB:FBgn0036899
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG8780; Dmel\CG8780; Tey
Summary
Predicted to enable ubiquitin protein ligase activity. Involved in negative regulation of transcription, DNA-templated and synaptic target recognition. Located in nucleus. Is expressed in several structures, including dorsal thoracic disc; embryonic brain; embryonic/larval nervous system; muscle cell; and visceral muscle primordium. [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See tey in Genome Data Viewer
Location:
76B11-76C1; 3-46 cM
Exon count:
10
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (19650506..19664104, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (19643606..19657204, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Ring finger protein 146 Neighboring gene Ornithine aminotransferase precursor Neighboring gene long non-coding RNA:CR44678 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Drosophila Tey represses transcription of the repulsive cue Toll and generates neuromuscular target specificity. Inaki M, et al. Development, 2010 Jul. PMID 20504957, Free PMC Article
  2. Role of FGFR signaling in the morphogenesis of the Drosophila visceral musculature. Mandal L, et al. Dev Dyn, 2004 Oct. PMID 15366011
  3. A glutamate receptor-interacting protein homolog organizes muscle guidance in Drosophila. Swan LE, et al. Genes Dev, 2004 Jan 15. PMID 14729572, Free PMC Article
  4. Target-dependent retrograde signaling mediates synaptic plasticity at the Drosophila neuromuscular junction. Berke B, et al. Dev Neurobiol, 2019 Nov. PMID 31950660, Free PMC Article
  5. The UBX-regulated network in the haltere imaginal disc of D. melanogaster. Hersh BM, et al. Dev Biol, 2007 Feb 15. PMID 17174297, Free PMC Article

See all (45) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The RNF220 domain nuclear factor Teyrha-Meyrha (Tey) regulates the migration and differentiation of specific visceral and somatic muscles in Drosophila.
    Title: The RNF220 domain nuclear factor Teyrha-Meyrha (Tey) regulates the migration and differentiation of specific visceral and somatic muscles in Drosophila.
  2. Results suggest that Tey determines target specificity by repressing the expression of Toll; these results reveal a mechanism for generating synaptic specificity that relies on the negative regulation of a repulsive target cue.
    Title: Drosophila Tey represses transcription of the repulsive cue Toll and generates neuromuscular target specificity.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in negative regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in synaptic target recognition IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
teyrha-meyrha
Names
CG8780-PA
CG8780-PB
CG8780-PC
CG8780-PD
tey-PA
tey-PB
tey-PC
tey-PD
teyrha meyrha
teyrha-meyhra

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    19650506..19664104 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001275130.2 → NP_001262059.1  teyrha-meyrha, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262059.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PCZ6
    Conserved Domains (1) summary
    pfam15926
    Location:318 → 449
    RNF220; E3 ubiquitin-protein ligase RNF220

  2. NM_001144509.3 → NP_001137981.1  teyrha-meyrha, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001137981.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    B7Z079
    Conserved Domains (1) summary
    pfam15926
    Location:328 → 459
    RNF220; E3 ubiquitin-protein ligase RNF220

  3. NM_001275131.1 → NP_001262060.1  teyrha-meyrha, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262060.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PFP2
    Conserved Domains (1) summary
    pfam15926
    Location:270 → 401
    RNF220; E3 ubiquitin-protein ligase RNF220

  4. NM_140883.2 → NP_649140.1  teyrha-meyrha, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_649140.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VW27
    Related
    FBpp0074728
    Conserved Domains (1) summary
    pfam15926
    Location:328 → 459
    RNF220; E3 ubiquitin-protein ligase RNF220
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B7Z079 B7Z079
M9PCZ6 M9PCZ6
M9PFP2 M9PFP2
Q8SY01 Q8SY01
Q9VW27.2 Q9VW27

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