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ZBTB34 zinc finger and BTB domain containing 34 [ Homo sapiens (human) ]

Gene ID: 403341, updated on 3-Apr-2024

Summary

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Official Symbol
ZBTB34provided by HGNC
Official Full Name
zinc finger and BTB domain containing 34provided by HGNC
Primary source
HGNC:HGNC:31446
See related
Ensembl:ENSG00000177125 MIM:611692; AllianceGenome:HGNC:31446
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZNF918
Summary
Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bone marrow (RPKM 6.2), placenta (RPKM 3.9) and 25 other tissues See more
Orthologs
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Genomic context

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See ZBTB34 in Genome Data Viewer
Location:
9q33.3
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (126860639..126885878)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (139066368..139092302)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (129622918..129648157)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107987129 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:129482087-129482586 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29018 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20290 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20291 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_106693 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_106710 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29019 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:129567045-129567546 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20292 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29020 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29021 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:129594985-129595486 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:129595487-129595986 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29022 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29023 Neighboring gene zinc finger and BTB domain containing 43 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20293 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:129623061-129623858 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20294 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:129630751-129631332 Neighboring gene NANOG hESC enhancer GRCh37_chr9:129645854-129646429 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:129648667-129649167 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20297 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29024 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29025 Neighboring gene Ral GEF with PH domain and SH3 binding motif 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29028 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29027 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29026 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29029 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29030 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29031 Neighboring gene uncharacterized LOC105376279 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:129792702-129793202 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:129829482-129829982 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:129874135-129874746 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:129884227-129884860 Neighboring gene angiopoietin like 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:129884861-129885494

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. ZBTB34, a novel human BTB/POZ zinc finger protein, is a potential transcriptional repressor. Qi J, et al. Mol Cell Biochem, 2006 Oct. PMID 16718364
  2. Characterization of size-fractionated cDNA libraries generated by the in vitro recombination-assisted method. Ohara O, et al. DNA Res, 2002 Apr 30. PMID 12056414
  3. Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. Li X, et al. Mol Syst Biol, 2015 Jan 21. PMID 25609649, Free PMC Article
  4. Toward a confocal subcellular atlas of the human proteome. Barbe L, et al. Mol Cell Proteomics, 2008 Mar. PMID 18029348
  5. A reference map of the human binary protein interactome. Luck K, et al. Nature, 2020 Apr. PMID 32296183, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ22470, KIAA1993, MGC24652

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
  
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of cytokine production IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of immune system process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of chromatin ISA
Inferred from Sequence Alignment
more info
  
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger and BTB domain-containing protein 34

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001099270.4 → NP_001092740.2  zinc finger and BTB domain-containing protein 34 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL160169, AL354944
    Consensus CDS
    CCDS48023.2
    UniProtKB/Swiss-Prot
    Q38IA7, Q5VYE9, Q8NCN2
    UniProtKB/TrEMBL
    A0A0C4DFQ2
    Related
    ENSP00000317534.4, ENST00000319119.5
    Conserved Domains (5) summary
    smart00355
    Location:376 → 398
    ZnF_C2H2; zinc finger
    sd00017
    Location:378 → 398
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18220
    Location:11 → 130
    BTB_POZ_ZBTB34; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 34 (ZBTB34)
    pfam00096
    Location:432 → 453
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:390 → 415
    zf-H2C2_2; Zinc-finger double domain

  2. NM_001395198.1 → NP_001382127.1  zinc finger and BTB domain-containing protein 34 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL160169, AL354944
    Consensus CDS
    CCDS94483.1
    UniProtKB/Swiss-Prot
    Q38IA7, Q5VYE9, Q8NCN2
    UniProtKB/TrEMBL
    A0A8Q3WKM1
    Related
    ENSP00000512077.1, ENST00000695642.1
    Conserved Domains (4) summary
    sd00017
    Location:388 → 408
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18220
    Location:21 → 140
    BTB_POZ_ZBTB34; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 34 (ZBTB34)
    pfam00096
    Location:442 → 463
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:400 → 425
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    126860639..126885878
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011518699.4 → XP_011517001.1  zinc finger and BTB domain-containing protein 34 isoform X2

    See identical proteins and their annotated locations for XP_011517001.1

    UniProtKB/Swiss-Prot
    Q38IA7, Q5VYE9, Q8NCN2
    UniProtKB/TrEMBL
    A0A0C4DFQ2
    Conserved Domains (5) summary
    smart00355
    Location:376 → 398
    ZnF_C2H2; zinc finger
    sd00017
    Location:378 → 398
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18220
    Location:11 → 130
    BTB_POZ_ZBTB34; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 34 (ZBTB34)
    pfam00096
    Location:432 → 453
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:390 → 415
    zf-H2C2_2; Zinc-finger double domain

  2. XM_047423402.1 → XP_047279358.1  zinc finger and BTB domain-containing protein 34 isoform X1

    UniProtKB/TrEMBL
    A0A8Q3WKM1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    139066368..139092302
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054362986.1 → XP_054218961.1  zinc finger and BTB domain-containing protein 34 isoform X2

    UniProtKB/TrEMBL
    A0A0C4DFQ2

  2. XM_054362985.1 → XP_054218960.1  zinc finger and BTB domain-containing protein 34 isoform X1

    UniProtKB/TrEMBL
    A0A8Q3WKM1

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_203482.1: Suppressed sequence

    Description
    NM_203482.1: This RefSeq was permanently suppressed because it is primarily UTR sequence.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8NCN2.4 GenPept UniProtKB/Swiss-Prot:Q8NCN2

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