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BRCA1 BRCA1 DNA repair associated [ Canis lupus familiaris (dog) ]

Gene ID: 403437, updated on 23-Jun-2022

Summary

Official Symbol
BRCA1provided by VGNC
Official Full Name
BRCA1 DNA repair associatedprovided by VGNC
Primary source
VGNC:VGNC:38516
See related
Ensembl:ENSCAFG00845006070
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
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Genomic context

See BRCA1 in Genome Data Viewer
Location:
chromosome: 9
Exon count:
27
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 9 NC_051813.1 (20677057..20743989)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 9 NC_006591.4 (19422566..19486083)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 9 NC_049230.1 (19833116..19896786)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 9 NC_049269.1 (19464421..19527988)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 9 NC_049750.1 (19730981..19794752)
105 previous assembly CanFam3.1 (GCF_000002285.3) 9 NC_006591.3 (19958941..20025494)

Chromosome 9 - NC_051813.1Genomic Context describing neighboring genes Neighboring gene U2 spliceosomal RNA Neighboring gene coiled-coil domain containing 200 Neighboring gene transmembrane protein 106A Neighboring gene NBR1 autophagy cargo receptor Neighboring gene Rho family GTPase 2 Neighboring gene vesicle amine transport 1

Genomic regions, transcripts, and products

Bibliography

General gene information

Homology

Gene Ontology Provided by GO

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables RNA polymerase binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables transcription coactivator activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables ubiquitin-protein transferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in fatty acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of fatty acid biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of DNA-templated transcription ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein K6-linked ubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein autoubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
part_of BRCA1-BARD1 complex ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in chromosome ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
breast cancer type 1 susceptibility protein homolog
Names
BRCA1 homolog
RING-type E3 ubiquitin transferase BRCA1
breast and ovarian cancer susceptibility protein 1
NP_001013434.1
XP_038530837.1
XP_038530838.1
XP_038530840.1
XP_038530841.1
XP_038530842.1
XP_038530843.1
XP_038530844.1
XP_038530845.1
XP_038530846.1
XP_038530847.1
XP_038530848.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013416.1NP_001013434.1  breast cancer type 1 susceptibility protein homolog

    See identical proteins and their annotated locations for NP_001013434.1

    Status: PROVISIONAL

    Source sequence(s)
    U50709
    UniProtKB/Swiss-Prot
    Q95153
    Conserved Domains (4) summary
    smart00292
    Location:17661850
    BRCT; breast cancer carboxy-terminal domain
    cd00027
    Location:16531727
    BRCT; Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo ...
    cd00162
    Location:2368
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    pfam12820
    Location:342505
    BRCT_assoc; Serine-rich domain associated with BRCT

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051813.1 Reference ROS_Cfam_1.0

    Range
    20677057..20743989
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038674913.1XP_038530841.1  breast cancer type 1 susceptibility protein homolog isoform X3

    Conserved Domains (4) summary
    cd16498
    Location:1878
    RING-HC_BRCA1; RING finger, HC subclass, found in breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    cd17721
    Location:17791876
    BRCT_BRCA1_rpt2; second (C-terminal) BRCT domain of breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    cd17735
    Location:16661762
    BRCT_BRCA1_rpt1; first BRCT domain of breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    pfam12820
    Location:355518
    BRCT_assoc; Serine-rich domain associated with BRCT
  2. XM_038674915.1XP_038530843.1  breast cancer type 1 susceptibility protein homolog isoform X4

    Related
    ENSCAFP00845008432.1, ENSCAFT00845010804.1
    Conserved Domains (5) summary
    TIGR00599
    Location:15121
    rad18; DNA repair protein rad18
    cd16498
    Location:1865
    RING-HC_BRCA1; RING finger, HC subclass, found in breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    cd17721
    Location:17661863
    BRCT_BRCA1_rpt2; second (C-terminal) BRCT domain of breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    cd17735
    Location:16531749
    BRCT_BRCA1_rpt1; first BRCT domain of breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    pfam12820
    Location:342505
    BRCT_assoc; Serine-rich domain associated with BRCT
  3. XM_038674918.1XP_038530846.1  breast cancer type 1 susceptibility protein homolog isoform X5

    Conserved Domains (5) summary
    TIGR00599
    Location:58164
    rad18; DNA repair protein rad18
    cd16498
    Location:61108
    RING-HC_BRCA1; RING finger, HC subclass, found in breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    cd17735
    Location:16961792
    BRCT_BRCA1_rpt1; first BRCT domain of breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    pfam12820
    Location:385548
    BRCT_assoc; Serine-rich domain associated with BRCT
    cl00038
    Location:18091829
    BRCT; C-terminal domain of the breast cancer suppressor protein (BRCA1) and related domains
  4. XM_038674909.1XP_038530837.1  breast cancer type 1 susceptibility protein homolog isoform X1

    Conserved Domains (4) summary
    cd16498
    Location:61121
    RING-HC_BRCA1; RING finger, HC subclass, found in breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    cd17721
    Location:18221919
    BRCT_BRCA1_rpt2; second (C-terminal) BRCT domain of breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    cd17735
    Location:17091805
    BRCT_BRCA1_rpt1; first BRCT domain of breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    pfam12820
    Location:398561
    BRCT_assoc; Serine-rich domain associated with BRCT
  5. XM_038674910.1XP_038530838.1  breast cancer type 1 susceptibility protein homolog isoform X2

    Conserved Domains (5) summary
    TIGR00599
    Location:58164
    rad18; DNA repair protein rad18
    cd16498
    Location:61108
    RING-HC_BRCA1; RING finger, HC subclass, found in breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    cd17721
    Location:18091906
    BRCT_BRCA1_rpt2; second (C-terminal) BRCT domain of breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    cd17735
    Location:16961792
    BRCT_BRCA1_rpt1; first BRCT domain of breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    pfam12820
    Location:385548
    BRCT_assoc; Serine-rich domain associated with BRCT
  6. XM_038674919.1XP_038530847.1  breast cancer type 1 susceptibility protein homolog isoform X6

    Conserved Domains (3) summary
    cd16498
    Location:61121
    RING-HC_BRCA1; RING finger, HC subclass, found in breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    cd17721
    Location:712809
    BRCT_BRCA1_rpt2; second (C-terminal) BRCT domain of breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    cd17735
    Location:599695
    BRCT_BRCA1_rpt1; first BRCT domain of breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
  7. XM_038674920.1XP_038530848.1  breast cancer type 1 susceptibility protein homolog isoform X7

    Related
    ENSCAFP00845008453.1, ENSCAFT00845010832.1
    Conserved Domains (4) summary
    TIGR00599
    Location:58164
    rad18; DNA repair protein rad18
    cd16498
    Location:61108
    RING-HC_BRCA1; RING finger, HC subclass, found in breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    cd17721
    Location:699796
    BRCT_BRCA1_rpt2; second (C-terminal) BRCT domain of breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    cd17735
    Location:586682
    BRCT_BRCA1_rpt1; first BRCT domain of breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
  8. XM_038674914.1XP_038530842.1  breast cancer type 1 susceptibility protein homolog isoform X3

    Conserved Domains (4) summary
    cd16498
    Location:1878
    RING-HC_BRCA1; RING finger, HC subclass, found in breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    cd17721
    Location:17791876
    BRCT_BRCA1_rpt2; second (C-terminal) BRCT domain of breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    cd17735
    Location:16661762
    BRCT_BRCA1_rpt1; first BRCT domain of breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    pfam12820
    Location:355518
    BRCT_assoc; Serine-rich domain associated with BRCT
  9. XM_038674912.1XP_038530840.1  breast cancer type 1 susceptibility protein homolog isoform X3

    Conserved Domains (4) summary
    cd16498
    Location:1878
    RING-HC_BRCA1; RING finger, HC subclass, found in breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    cd17721
    Location:17791876
    BRCT_BRCA1_rpt2; second (C-terminal) BRCT domain of breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    cd17735
    Location:16661762
    BRCT_BRCA1_rpt1; first BRCT domain of breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    pfam12820
    Location:355518
    BRCT_assoc; Serine-rich domain associated with BRCT
  10. XM_038674917.1XP_038530845.1  breast cancer type 1 susceptibility protein homolog isoform X4

    Conserved Domains (5) summary
    TIGR00599
    Location:15121
    rad18; DNA repair protein rad18
    cd16498
    Location:1865
    RING-HC_BRCA1; RING finger, HC subclass, found in breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    cd17721
    Location:17661863
    BRCT_BRCA1_rpt2; second (C-terminal) BRCT domain of breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    cd17735
    Location:16531749
    BRCT_BRCA1_rpt1; first BRCT domain of breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    pfam12820
    Location:342505
    BRCT_assoc; Serine-rich domain associated with BRCT
  11. XM_038674916.1XP_038530844.1  breast cancer type 1 susceptibility protein homolog isoform X4

    Conserved Domains (5) summary
    TIGR00599
    Location:15121
    rad18; DNA repair protein rad18
    cd16498
    Location:1865
    RING-HC_BRCA1; RING finger, HC subclass, found in breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    cd17721
    Location:17661863
    BRCT_BRCA1_rpt2; second (C-terminal) BRCT domain of breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    cd17735
    Location:16531749
    BRCT_BRCA1_rpt1; first BRCT domain of breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    pfam12820
    Location:342505
    BRCT_assoc; Serine-rich domain associated with BRCT

RNA

  1. XR_005431678.1 RNA Sequence

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049269.1 Alternate UMICH_Zoey_3.1

    Range
    19464421..19527988
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049750.1 Alternate UNSW_CanFamBas_1.0

    Range
    19730981..19794752
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049230.1 Alternate UU_Cfam_GSD_1.0

    Range
    19833116..19896786
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006591.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    19422566..19486083
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)