PPP1CA protein phosphatase 1 catalytic subunit alpha [Canis lupus familiaris (dog)] - Gene

Summary

Official Symbol: PPP1CAprovided by VGNC
Official Full Name: protein phosphatase 1 catalytic subunit alphaprovided by VGNC
Primary source: VGNC:VGNC:111645
See related: Ensembl:ENSCAFG00845010538
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 18

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	18	NC_051822.1 (50984259..50987073)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	18	NC_006600.4 (48672765..48675579)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	18	NC_049239.1 (50566605..50569419)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	18	NC_049278.1 (50197606..50200420)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	18	NC_049759.1 (49772313..49775127)

Chromosome 18 - NC_051822.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Par-3 functions as a scaffold, coordinating both serine/threonine kinases and the PP1alpha phosphatase
Title: Protein phosphatase 1 regulates the phosphorylation state of the polarity scaffold Par-3.

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General gene information

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Markers

Ppp1ca (e-PCR), detects polymorphism
- UniSTS:526866

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables protein serine/threonine phosphatase activity	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: serine/threonine-protein phosphatase PP1-alpha catalytic subunit

Names: PP-1A

NP_001003064.2

EC 3.1.3.16

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001003064.2 → NP_001003064.2 serine/threonine-protein phosphatase PP1-alpha catalytic subunit

Status: VALIDATED

Source sequence(s)

DN365927, DN392813, DN399649, DN746677, DN871864

UniProtKB/Swiss-Prot

Q8WMS6

UniProtKB/TrEMBL

A0A8C0JKG3, A0A8C0PCF1, A0A8I3NRM8

Related

ENSCAFP00845014515.1, ENSCAFT00845018606.1

Conserved Domains (1) summary

cd07414
Location:8 → 298

MPP_PP1_PPKL; PP1, PPKL (PP1 and kelch-like) enzymes, and related proteins, metallophosphatase domain