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CREM cAMP responsive element modulator [ Canis lupus familiaris (dog) ]

Gene ID: 403887, updated on 5-Mar-2024

Summary

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Official Symbol
CREMprovided by VGNC
Official Full Name
cAMP responsive element modulatorprovided by VGNC
Primary source
VGNC:VGNC:52123
See related
Ensembl:ENSCAFG00845001664
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 2
Exon count:
16
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 2 NC_051806.1 (2037957..2111330, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 2 NC_006584.4 (1843669..1893973, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 2 NC_049223.1 (1973934..2024249, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 2 NC_049262.1 (1809553..1859860, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 2 NC_049743.1 (1853133..1903529, complement)

Chromosome 2 - NC_051806.1Genomic Context describing neighboring genes Neighboring gene cyclin Y Neighboring gene uncharacterized LOC119870079 Neighboring gene 40S ribosomal protein S6-like Neighboring gene uncharacterized LOC111091150 Neighboring gene axin interactor, dorsalization-associated protein-like Neighboring gene protein SGT1 homolog Neighboring gene cullin 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Dog CREM transcription factors: cloning, tissue distribution, and identification of new isoforms. Uyttersprot N, et al. Biochem Biophys Res Commun, 1997 Aug 8. PMID 9266832
  2. Molecular phylogenetics and the origins of placental mammals. Murphy WJ, et al. Nature, 2001 Feb 1. PMID 11214319

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of ATF4-CREB1 transcription factor complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
cAMP-responsive element modulator
Names
cAMP responsive element moderator

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001003221.1 → NP_001003221.1  cAMP-responsive element modulator

    See identical proteins and their annotated locations for NP_001003221.1

    Status: PROVISIONAL

    Source sequence(s)
    X99115
    UniProtKB/TrEMBL
    A0A8C0JHE2
    Conserved Domains (2) summary
    cd14690
    Location:288 → 342
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:101 → 138
    pKID; pKID domain

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051806.1 Reference ROS_Cfam_1.0

    Range
    2037957..2111330 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038657747.1 → XP_038513675.1  cAMP-responsive element modulator isoform X19

    Conserved Domains (2) summary
    cd14690
    Location:180 → 234
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:69 → 105
    pKID; pKID domain

  2. XM_038657745.1 → XP_038513673.1  cAMP-responsive element modulator isoform X17

    Conserved Domains (2) summary
    cd14690
    Location:192 → 246
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:69 → 105
    pKID; pKID domain

  3. XM_038657740.1 → XP_038513668.1  cAMP-responsive element modulator isoform X13

    UniProtKB/TrEMBL
    A0A8C0M6P8
    Conserved Domains (2) summary
    cd14690
    Location:229 → 283
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:118 → 154
    pKID; pKID domain

  4. XM_038657739.1 → XP_038513667.1  cAMP-responsive element modulator isoform X12

    UniProtKB/TrEMBL
    A0A8C0M6P8
    Conserved Domains (2) summary
    cd14690
    Location:241 → 295
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:118 → 154
    pKID; pKID domain

  5. XM_038657737.1 → XP_038513665.1  cAMP-responsive element modulator isoform X10

    UniProtKB/TrEMBL
    A0A8C0QT68
    Conserved Domains (2) summary
    cd14690
    Location:243 → 297
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:69 → 105
    pKID; pKID domain

  6. XM_038657729.1 → XP_038513657.1  cAMP-responsive element modulator isoform X3

    UniProtKB/TrEMBL
    A0A8C0JHE2
    Conserved Domains (2) summary
    cd14690
    Location:292 → 346
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:118 → 154
    pKID; pKID domain

  7. XM_038657734.1 → XP_038513662.1  cAMP-responsive element modulator isoform X7

    UniProtKB/TrEMBL
    A0A8C0QT68
    Conserved Domains (2) summary
    cd14690
    Location:255 → 309
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:69 → 105
    pKID; pKID domain

  8. XM_038657731.1 → XP_038513659.1  cAMP-responsive element modulator isoform X5

    UniProtKB/TrEMBL
    A0A8C0JHE2
    Conserved Domains (2) summary
    cd14690
    Location:288 → 342
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:102 → 138
    pKID; pKID domain

  9. XM_038657727.1 → XP_038513655.1  cAMP-responsive element modulator isoform X1

    UniProtKB/TrEMBL
    A0A8C0JHE2
    Conserved Domains (2) summary
    cd14690
    Location:304 → 358
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:118 → 154
    pKID; pKID domain

  10. XM_038657749.1 → XP_038513677.1  cAMP-responsive element modulator isoform X21

    UniProtKB/TrEMBL
    A0A8C0JL10
    Conserved Domains (2) summary
    cd14690
    Location:149 → 203
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:38 → 74
    pKID; pKID domain

  11. XM_038657742.1 → XP_038513670.1  cAMP-responsive element modulator isoform X15

    UniProtKB/TrEMBL
    A0A8C0JHK9
    Conserved Domains (2) summary
    cd14690
    Location:212 → 266
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:38 → 74
    pKID; pKID domain

  12. XM_038657741.1 → XP_038513669.1  cAMP-responsive element modulator isoform X14

    UniProtKB/TrEMBL
    A0A8C0Q3A4, A0A8C0QT68, A0A8I3RRT1
    Related
    ENSCAFP00845002619.1, ENSCAFT00845003302.1
    Conserved Domains (2) summary
    cd14690
    Location:224 → 278
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:38 → 74
    pKID; pKID domain

  13. XM_038657732.1 → XP_038513660.1  cAMP-responsive element modulator isoform X6

    UniProtKB/TrEMBL
    A0A8C0JHE2
    Conserved Domains (2) summary
    cd14690
    Location:273 → 327
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:87 → 123
    pKID; pKID domain

  14. XM_038657736.1 → XP_038513664.1  cAMP-responsive element modulator isoform X9

    UniProtKB/TrEMBL
    A0A8C0JHE2
    Conserved Domains (2) summary
    cd14690
    Location:249 → 303
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:63 → 99
    pKID; pKID domain

  15. XM_038657743.1 → XP_038513671.1  cAMP-responsive element modulator isoform X16

    UniProtKB/TrEMBL
    A0A8C0QT68
    Conserved Domains (2) summary
    cd14690
    Location:200 → 254
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:14 → 50
    pKID; pKID domain

  16. XM_038657752.1 → XP_038513680.1  cAMP-responsive element modulator isoform X24

    UniProtKB/TrEMBL
    A0A8P0P8W7
    Conserved Domains (1) summary
    cd14690
    Location:57 → 111
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain

  17. XM_038657750.1 → XP_038513678.1  cAMP-responsive element modulator isoform X22

    UniProtKB/TrEMBL
    A0A8C0M704, A0A8I3MJ55
    Conserved Domains (1) summary
    cd14690
    Location:69 → 123
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain

  18. XM_038657757.1 → XP_038513685.1  cAMP-responsive element modulator isoform X28

    UniProtKB/TrEMBL
    A0A8P0P8W7
    Conserved Domains (1) summary
    cd14690
    Location:39 → 93
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain

  19. XM_038657754.1 → XP_038513682.1  cAMP-responsive element modulator isoform X26

    UniProtKB/TrEMBL
    A0A8P0P8W7
    Conserved Domains (1) summary
    cd14690
    Location:46 → 100
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain

  20. XM_038657756.1 → XP_038513684.1  cAMP-responsive element modulator isoform X27

    UniProtKB/TrEMBL
    A0A8P0P8W7
    Conserved Domains (1) summary
    cd14690
    Location:46 → 100
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain

  21. XM_038657728.1 → XP_038513656.1  cAMP-responsive element modulator isoform X2

    UniProtKB/Swiss-Prot
    P79145
    UniProtKB/TrEMBL
    A0A8C0JHE2
    Related
    ENSCAFP00845002571.1, ENSCAFT00845003241.1
    Conserved Domains (2) summary
    cd14690
    Location:304 → 358
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:118 → 154
    pKID; pKID domain

  22. XM_038657748.1 → XP_038513676.1  cAMP-responsive element modulator isoform X20

    UniProtKB/TrEMBL
    A0A8C0M6P8, A0A8I3N049, A0A8P0PC73
    Related
    ENSCAFP00845002581.1, ENSCAFT00845003254.1
    Conserved Domains (2) summary
    cd14690
    Location:180 → 234
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:69 → 105
    pKID; pKID domain

  23. XM_038657746.1 → XP_038513674.1  cAMP-responsive element modulator isoform X18

    UniProtKB/TrEMBL
    A0A8C0M6P8, A0A8C0PM92, A0A8I3MIZ8
    Related
    ENSCAFP00845002577.1, ENSCAFT00845003249.1
    Conserved Domains (2) summary
    cd14690
    Location:192 → 246
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:69 → 105
    pKID; pKID domain

  24. XM_038657738.1 → XP_038513666.1  cAMP-responsive element modulator isoform X11

    UniProtKB/TrEMBL
    A0A8C0QT68, A0A8C0RUS7, A0A8I3RQ88
    Related
    ENSCAFP00845002572.1, ENSCAFT00845003243.1
    Conserved Domains (2) summary
    cd14690
    Location:243 → 297
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:69 → 105
    pKID; pKID domain

  25. XM_038657730.1 → XP_038513658.1  cAMP-responsive element modulator isoform X4

    UniProtKB/TrEMBL
    A0A8C0JHE2
    Conserved Domains (2) summary
    cd14690
    Location:292 → 346
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:118 → 154
    pKID; pKID domain

  26. XM_038657735.1 → XP_038513663.1  cAMP-responsive element modulator isoform X8

    UniProtKB/TrEMBL
    A0A8C0QT68
    Conserved Domains (2) summary
    cd14690
    Location:255 → 309
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:69 → 105
    pKID; pKID domain

  27. XM_038657753.1 → XP_038513681.1  cAMP-responsive element modulator isoform X25

    UniProtKB/TrEMBL
    A0A8C0PLB2, A0A8P0P8W7
    Conserved Domains (1) summary
    cd14690
    Location:57 → 111
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain

  28. XM_038657751.1 → XP_038513679.1  cAMP-responsive element modulator isoform X23

    UniProtKB/TrEMBL
    A0A8C0M704, A0A8I3MJ55
    Related
    ENSCAFP00845002392.1, ENSCAFT00845003000.1
    Conserved Domains (1) summary
    cd14690
    Location:69 → 123
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049262.1 Alternate UMICH_Zoey_3.1

    Range
    1809553..1859860 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049743.1 Alternate UNSW_CanFamBas_1.0

    Range
    1853133..1903529 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049223.1 Alternate UU_Cfam_GSD_1.0

    Range
    1973934..2024249 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006584.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    1843669..1893973 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P79145.2 GenPept UniProtKB/Swiss-Prot:P79145

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